Cooperative Capture of Uranyl Ions by a Carbonyl‐Bearing Hierarchical‐Porous Cu–Organic Framework

Wang, Xiao‐Feng; Chen, Yangyang; Song, Liping; Fang, Zhen; Zhang, Jian; Shi, Fa‐Nian; Lin, Ying‐Wu; Sun, Yunkai; Zhang, Yue‐Biao; Rocha, João

doi:10.1002/anie.201909045

Cited by 51 publications

(27 citation statements)

References 58 publications

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“…Secondly, although both model peptides and de novo proteins have been designed to bind uranyl ions specifically [10,36], it is still expected to design more artificial peptides/proteins with high stability for selective uranyl binding, and to apply them for construction of new biomaterials, or hybrid materials [99], aimed at selective extraction of UO 2 2+ from seawater in a large scale.…”

Section: Fetuin-a 3 Binding Sites~30 Nm-10 µMmentioning

confidence: 99%

Uranyl Binding to Proteins and Structural-Functional Impacts

Lin

2020

Biomolecules

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The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO 2 2+ ). Although uranyl-protein/DNA interactions have been known for decades, fewer advances are made in understanding their structural-functional impacts. Instead of focusing only on the structural information, this article aims to review the recent advances in understanding the binding of uranyl to proteins in either potential, native, or artificial metal-binding sites, and the structural-functional impacts of uranyl-protein interactions, such as inducing conformational changes and disrupting protein-protein/DNA/ligand interactions. Photo-induced protein/DNA cleavages, as well as other impacts, are also highlighted. These advances shed light on the structure-function relationship of proteins, especially for metalloproteins, as impacted by uranyl-protein interactions. It is desired to seek approaches for biological remediation of uranyl ions, and ultimately make a full use of the double-edged sword of uranium.Proteins, especially for metalloproteins, play vital roles in supporting life, including electron-transfer, O 2 -binding and delivery, and catalysis, etc [11][12][13][14][15][16][17][18]. To date, a plenitude of proteins have been shown to interact with UO 2 2+ , such as proteins in blood (human serum albumin, HSA; transferrin, Tf;hemoglobin, Hb), proteins involved in bone growth (osteopontin, OPN; fetuin-A), and the intracellar proteins (metallothionein, MT; cytochromes b 5 /c; Cyt b 5 /c; calmodulin, CaM), etc [19]. Although the structural features of some uranyl-protein complexes are well-documented [7-9], fewer advances are made in understanding the functional impacts of uranyl-protein interactions, with much less for other actinides-proteins interactions, as reviewed by Creff et al. very recently [20]. Instead of focusing only on the structural information, this review highlights the recent advances in understanding the binding of uranyl to proteins, as illustrated in Scheme 1, in either potential, native or artificial metal-binding sites, or the corresponding structural-functional impacts, such as inducing conformational changes and disrupting protein-protein/DNA/ligand interactions. Future directions for studying uranyl-protein interactions are also prospected.

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Section: Fetuin-a 3 Binding Sites~30 Nm-10 µMmentioning

confidence: 99%

Uranyl Binding to Proteins and Structural-Functional Impacts

Lin

2020

Biomolecules

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“…N-phenyl-N'-phenyl bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxdiimide tetracarboxylic acid (H 4 PTTA) was synthesized as described in the literature [29]: a mixture of 5-Aminoisophthalic acid (1.82 g, 10.05 mmol) and bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid dianhydride (1.24 g, 5 mmol) in N,N'-Dimethylformamide (DMF, 20 mL) was refluxed for 12 h and then cooled down to room temperature. The yellow solution was poured into 500 mL deionized water and the pH was adjusted to 2 (with 5 M HCl) to form a white suspension.…”

Section: General Materials and Methodsmentioning

confidence: 99%

Two Unexpected Temperature-Induced Supermolecular Isomers from Multi-Topic Carboxylic Acid: Hydrogen Bonding Layer or Helix Tube

Tan

Zhou

et al. 2021

Molecules

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Under ambient conditions or 160 °C, two supramolecular isomers, namely [(H4PTTA)(H2O)2(DMF)] and [(H4PTTA)(H2O)3]··Guest (1-L and 1-H, H4PTTA = N-phenyl-N′-phenyl bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxdiimide tetra-carboxylic acid, Guest = DMF and H2O), were obtained through the reaction of H4PTTA in a mixture of H2O and dimethylformamide. The single crystal structures reveal the temperature-dependent supramolecular isomerism derived from the torsion of semi-rigid of H4PTTA. The 1-L prepared at room temperature is a hydrogen bond based achiral layer, while the hydrothermal synthesized 1-H is isomer resulted in an H-bond-based chiral tubes-packed supramolecular framework.

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“…(d) PXRD of pristine USC‐CP‐1 (1‐H), UO 2 2+ @ USC‐CP‐1 (1‐H), and regenerated USC‐CP‐1 (1‐H). (e) Regeneration performance of UO 2 2+ @1‐L [20d] . Reprinted with permission from ref.…”

Section: Advanced Mofs With Well‐designed Metal Centers or Ligandsmentioning

confidence: 99%

“…Wang et al. reported a carbonyl modified 3D MOF USC‐CP‐1 with dynamic structure based on the coordination of Cu‐based SBU (Cu 2 (RCOO) 4 (H 2 O) 2 ) and semi‐rigid tetra‐carboxylate ligand (N,N’‐bis(isophthalate)bicyclo[2.2.2]oct‐7‐ene diimide) [20d] . USC‐CP‐1 possessed three types of polyhedral cages and interconnected micro‐macro hierarchically porous structure.…”

Section: Advanced Mofs With Well‐designed Metal Centers or Ligandsmentioning

confidence: 99%

Metal‐Organic‐Framework Based Functional Materials for Uranium Recovery: Performance Optimization and Structure/Functionality‐Activity Relationships

et al. 2021

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Uranium recovery has profound significance in both uranium resource acquisition and pollution treatment. In recent years, metal‐organic frameworks (MOFs) have attracted much attention as potential uranium adsorbents owing to their tunable structural topology and designable functionalities. This review explores the research progress in representative classic MOFs (MIL‐101, UiO‐66, ZIF‐8/ZIF‐67) and other advanced MOF‐based materials for efficient uranium extraction in aqueous or seawater environments. The uranium uptake mechanism of the MOF‐based materials is refined, and the structure/functionality‐property relationship is further systematically elucidated. By summarizing the typical functionalization and structure design methods, the performance improvement strategies for MOF‐based adsorbents are emphasized. Finally, the present challenges and potential opportunities are proposed for the breakthrough of high‐performance MOF‐based materials in uranium extraction.

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Cooperative Capture of Uranyl Ions by a Carbonyl‐Bearing Hierarchical‐Porous Cu–Organic Framework

Cited by 51 publications

References 58 publications

Uranyl Binding to Proteins and Structural-Functional Impacts

Uranyl Binding to Proteins and Structural-Functional Impacts

Two Unexpected Temperature-Induced Supermolecular Isomers from Multi-Topic Carboxylic Acid: Hydrogen Bonding Layer or Helix Tube

Metal‐Organic‐Framework Based Functional Materials for Uranium Recovery: Performance Optimization and Structure/Functionality‐Activity Relationships

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