2017
DOI: 10.1039/c7cc04796g
|View full text |Cite
|
Sign up to set email alerts
|

Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

Abstract: Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooperative co-assembly of a structure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ions.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
77
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 63 publications
(79 citation statements)
references
References 47 publications
2
77
0
Order By: Relevance
“…38 Some have even been able to look at stacks of molecules, simulating what a fibre could look like. 9,39 The problems facing computational methods is that the more molecules are involved in the calculations, the longer and more difficult the calculations are to do. It is also difficult to take into account the solvent environment and changing conditions that occur as the molecules are assembling (gels are triggered from a dissolved or dispersed state to a gelled state, so the self-assembly occurs generally in a changing environment).…”
Section: Computational Modellingmentioning
confidence: 99%
“…38 Some have even been able to look at stacks of molecules, simulating what a fibre could look like. 9,39 The problems facing computational methods is that the more molecules are involved in the calculations, the longer and more difficult the calculations are to do. It is also difficult to take into account the solvent environment and changing conditions that occur as the molecules are assembling (gels are triggered from a dissolved or dispersed state to a gelled state, so the self-assembly occurs generally in a changing environment).…”
Section: Computational Modellingmentioning
confidence: 99%
“…The dipeptide and tripeptide sequences are the common approaches to show the peptide self‐assembly at the nanometer scale, which is discovered and expanded by Gazit and Ulijn et al and studied widely to serve as discrete nanostructures in the broad areas. [ 68,126 ] Various factors can drive gelation formation of these ultrashort peptide sequences, such as amino acids residues, intermolecular interactions in noncovalent forces, the chirality change. [ 127 ] The exchange of just one amino acid may result in systematic alterations of peptide nanostructures, such as the tunable kinetics, mesh size, and scaffold morphologies at the nanometer scale.…”
Section: Diverse Self‐assembling Peptide Hydrogels and Their Applicatmentioning
confidence: 99%
“…21,22,29 Similar to polymeric hydrogels, the non-covalent interaction of peptide hydrogels also permits the development of multi-stimuli hydrogels. Several stimuli, including chemical stimulus, 30,31 enzyme 32,33 and light, 34 were reported.…”
mentioning
confidence: 99%