Cooperative tumour cell membrane targeted phototherapy

Abstract

The targeted delivery of therapeutics using antibodies or nanomaterials has improved the precision and safety of cancer therapy. However, the paucity and heterogeneity of identified molecular targets within tumours have resulted in poor and uneven distribution of targeted agents, thus compromising treatment outcomes. Here, we construct a cooperative targeting system in which synthetic and biological nanocomponents participate together in the tumour cell membrane-selective localization of synthetic receptor-lipid conjugates (SR-lipids) to amplify the subsequent targeting of therapeutics. The SR-lipids are first delivered selectively to tumour cell membranes in the perivascular region using fusogenic liposomes. By hitchhiking with extracellular vesicles secreted by the cells, the SR-lipids are transferred to neighbouring cells and further spread throughout the tumour tissues where the molecular targets are limited. We show that this tumour cell membrane-targeted delivery of SR-lipids leads to uniform distribution and enhanced phototherapeutic efficacy of the targeted photosensitizer.

Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective

“…Subcellular targeted nanoplatforms for precise tumor phototherapy. ( A ) Schematic representation of cooperative tumor cell membrane targeting nanosystem (Adapted with permission from 74, copyright 2017 Nature Publishing Group). ( B ) Schematic illustration of selenium-inserted polymeric nanoparticles (I/D-Se-NPs) with immediate drug release and highly efficient cytoplasmic translocation properties under NIR light exposure for synergistic thermo-chemotherapy (Adapted with permission from 212, copyright 2017 American Chemical Society).…”

“…In particular, the natural cell-derived vesicles like exosome, which originated from internal endocytic compartments and multi-vesicular bodies, can involve in intercellular communication by transporting macromolecules from one to another. Inspiringly, these exquisite nanoplatforms can be used for delivery of proteins, photosensitive molecules or photoactivation channels which are fruitful for precise regulation of targeted cell functions 74, 75. Furthermore, these transportations could be monitored with light irradiation by combining with the optogenetic tools as illustrated in Figure 1.…”

“…ROS release from Ce6 upon light irradiation rapidly induced necrosis-like cell death of Ce6 membrane bounded cells while free Ce6-SRs in the medium did not significantly introduce phototoxicity. Collectively, this type of nanoparticles embodied the powerful ability to improve precise tumor therapy 74.…”

Photocontrolled Release of the Anticancer Drug Chlorambucil with Caged Harmonic Nanoparticles

“…The strategy which was the most extensively explored to selectively address nanomaterials at cancer lesions is based on passive targeting resulting from the enhanced permeability and retention (EPR) effect through the non‐structured blood vessels which grow concomitantly to cancer cell invasion and tumor development . Actively targeted nanocarriers make use of surface functionalization with targeting ligands addressing biomarkers which are overexpressed or specifically expressed by cancer cells and cancer associated fibroblasts . Despite intense research efforts over the last 10 years, none of these actively targeted nanomaterials reached advanced clinical trials .…”

Coherence‐Tailored Multiwavelength High‐Speed Quantitative Phase Imaging with a High Phase Stability via a Frequency Comb

“…[ 1,2 ] Due to its noninvasive, label‐free, and quantitative nature, QPI has been widely applied to precision measurement of cellular morphology, refractive index (RI), and dry mass; [ 3–6 ] monitoring of intercellular communication of immune cells, neurons, and cancer cells; [ 7–10 ] and understanding the dynamics of red and white blood cells. [ 11–14 ]…”