Coordinate chloride and water-assisted assembly of novel 3D-cageworks of cadmium(II) complex with 4-[N,N-bis(2-cyanoethyl)]aminopyridine

Li, Yi‐Zhi; Ni, Jun; Zhang, Zhong; Wang, Zhilin

doi:10.1016/j.inoche.2005.09.020

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Indeed, the formation of Cd complexes with Cys, including [CdCys] + , [Cd(Cys) 2 ], [Cd(Cys) 3 ] − , [Cd 2 (Cys) 3 ] + [18], as well as [Cd(Cys) 4 ] 2− [19], some of which may also form at physiological pH, has been reported. In addition, Cd 2+ is also known to form mixed Cd complexes where the metal center is coordinated to organic functional groups as well as chloride atoms [20,21]. From a purely inorganic chemistry point of view, Cd 2+ has long been known to form [CdCl 3 ] − and [CdCl 4 ] 2− complexes in aqueous solutions [22].…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization of Toxicologically Relevant Cd2+-L-Cysteine Complexes

Gautam

Gomez

Rengifo

et al. 2023

Toxics

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The exposure of humans to Cd exerts adverse human health effects at low chronic exposure doses, but the underlying biomolecular mechanisms are incompletely understood. To gain insight into the toxicologically relevant chemistry of Cd2+ in the bloodstream, we employed an anion-exchange HPLC coupled to a flame atomic absorption spectrometer (FAAS) using a mobile phase of 100 mM NaCl with 5 mM Tris-buffer (pH 7.4) to resemble protein-free blood plasma. The injection of Cd2+ onto this HPLC-FAAS system was associated with the elution of a Cd peak that corresponded to [CdCl3]−/[CdCl4]2− complexes. The addition of 0.1–10 mM L-cysteine (Cys) to the mobile phase significantly affected the retention behavior of Cd2+, which was rationalized by the on-column formation of mixed CdCysxCly complexes. From a toxicological point of view, the results obtained with 0.1 and 0.2 mM Cys were the most relevant because they resembled plasma concentrations. The corresponding Cd-containing (~30 μM) fractions were analyzed by X-ray absorption spectroscopy and revealed an increased sulfur coordination to Cd2+ when the Cys concentration was increased from 0.1 to 0.2 mM. The putative formation of these toxicologically relevant Cd species in blood plasma was implicated in the Cd uptake into target organs and underscores the notion that a better understanding of the metabolism of Cd in the bloodstream is critical to causally link human exposure with organ-based toxicological effects.

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