This paper presents techniques for the application of tertiary and secondary voltage control through the use of intelligent proportional integral derivative (PID) controllers and the wide area measurement system (WAMS) in the IEEE 39 bus system (New England system). The paper includes power system partitioning, pilot bus selection, phasor measurement unit (PMU) placement, and optimal secondary voltage control parameter calculations to enable the application of the proposed voltage control. The power system simulation and analyses were performed using the DIgSILENT and MATLAB software applications. The optimal PMU placement was performed in order to apply secondary voltage control. The tertiary voltage control was performed through an optimal power flow optimization process in order to minimize the active power losses. Two different methods were used to design the PID secondary voltage control, namely, genetic algorithm (GA) and neural network based on genetic algorithm (NNGA). A comparison of system performances using these two methods under different operating conditions is presented. The results show that NNGA secondary PID controllers are more robust than GA ones. The paper also presents a comparison between system performance with and without secondary voltage control, in terms of voltage deviation index and total active power losses. The graph theory is used in system partitioning, and sensitivity analysis is used in pilot bus selection, the results of which proved their effectiveness.