Coordination compounds in cancer: Past, present and perspectives

Trudu, Federica; Amato, Filippo; Vaňhara, Petr; Pivetta, Tiziana; Peña‐Méndez, Eladia María; Havel, Josef

doi:10.1016/j.jab.2015.03.003

Cited by 136 publications

(80 citation statements)

References 231 publications

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“…Platinum (IV) prodrugs are considered one of the approaches developed to overcome the drawbacks of the Pt (II) drugs . The octahedral Pt (IV) complexes are activated by reduction inside the cell to the active platinum (II) counterparts before binding to their target DNA (Figure ) . The axial ligands in Pt (IV) complexes that are released upon reduction can be used to control important properties of the drug, such as stability, reduction potential and lipophilicity .…”

Section: Introductionmentioning

confidence: 99%

Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position

Tolan

Abdel‐Monem

El-Nagar

2019

Applied Organom Chemis

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The role of inflammation in cancer generation is gaining importance in the field of cancer research. The chemo‐anti‐inflammatory strategy that involves using non‐steroidal anti‐inflammatory drug compounds as effective anti‐tumor agents is being acceded globally. In the present study, seven new Pt (IV) complexes based on cisplatin, carboplatin and oxaliplatin scaffold bearing the anti‐inflammatory drug naproxen in the axial position were synthesized and characterized by elemental analysis, ESI‐MS, Fourier transform‐infrared, 1H‐ and 195Pt‐NMR spectroscopy. The reduction behavior in the presence of ascorbic acid was studied using high‐performance liquid chromatography. The cytotoxicity against two human breast cell lines and the anti‐inflammatory properties were evaluated. All the complexes are able to promote a comparable activity, with average three‐ and 13‐fold more cytotoxic than cisplatin against MCF7 and MDA‐MB‐231 cell lines, respectively. The complexes show remarkable anti‐inflammatory effects, which indicated their potential in treating cancer associated with inflammation and reducing side‐effects of chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position

Tolan

Abdel‐Monem

El-Nagar

2019

Applied Organom Chemis

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“…Hexacarbonyl dicobalt and alkynes exhibit a promising activity of antitumor activity [147]. The activity is most pronounced when the alkyne is the propargyl ester of aspirin (CoASS), which inhibits the cyclooxygenase enzymes COX-1 and COX-2 [147,148]. It was shown that CoASS itself inhibits COX-1 and COX-2 more strongly than ASA alone and enhanced the cytotoxicity against breast cancer cell line [148].…”

Section: Other Complexesmentioning

confidence: 99%

“…The activity is most pronounced when the alkyne is the propargyl ester of aspirin (CoASS), which inhibits the cyclooxygenase enzymes COX-1 and COX-2 [147,148]. It was shown that CoASS itself inhibits COX-1 and COX-2 more strongly than ASA alone and enhanced the cytotoxicity against breast cancer cell line [148]. The development of new complexes bearing different types of pyrazole-based ligands demonstrated the potential use of these complexes as antiproliferative agents [149].…”

Section: Other Complexesmentioning

confidence: 99%

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Pedrosa¹,

Carvalho²,

Baptista³

et al. 2018

Basic Concepts Viewed From Frontier in Inorganic Coordination Chemistry

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Metals have unique characteristics such as variable coordination modes, redox activity, and reactivity being indispensable for several biochemical processes in cells. Due to their reactivity, their concentration is tightly regulated inside the cells, and abnormal concentrations are associated with many disorders, such as cancer. As such metal complexes turned out to be very attractive as potential anticancer agents. The discovery of cisplatin was a crucial moment, which prompted the interest in Pt(II) and other metal complexes as potential anticancer agents. This chapter highlights the state of the art on metal complexes in cancer therapy, highlighting their uptake mechanisms, biological targets, toxicity, and drug resistance. Finally, based on the importance of selective target of cancer cells, drug delivery systems will also be discussed.

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“…Traditional platinum drugs, such as cisplatin, undergo aquation and bind covalently to the guanine base pairs in DNA, thereby forming intra‐ and interstrand crosslinks between the DNA strands. This causes a change in the secondary structure of DNA which prevents DNA replication and initiates apoptosis . DNA is accepted as the main target of the platinum‐based complexes, but further evidence suggests that only 1 % of the platinum complex administered actually reaches DNA.…”

Section: Introductionmentioning

confidence: 99%

Heterometallic Multinuclear Complexes as Anti‐Cancer Agents‐An Overview of Recent Developments

2019

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This review provides a critical assessment of the advances made in the development of heterometallic multinuclear complexes as potential chemotherapeutic agents, with the aim of providing a starting point for future investigators. The combination of the classical transition metals (Pt, Ru and Au) with other metal moieties has the potential to result in complexes with improved pharmacokinetic and pharmacodynamic properties. This enables selective targeting of the bio- [a] 3434 Figure 2. The Pt II -Ru III complexes, IT127 and AH-197, [35] and the macrocyclic rectangles investigated by Chi and colleagues. [36] The IC 50 (μM) values reported are shown below the chemical structures.

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Coordination compounds in cancer: Past, present and perspectives

Cited by 136 publications

References 231 publications

Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position

Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Heterometallic Multinuclear Complexes as Anti‐Cancer Agents‐An Overview of Recent Developments

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