Coordination geometry of tetradentate Schiff’s base nickel complexes: the effects of donors, backbone length and hydrogenation

Taylor, Michelle K.; Reglinski, John; Wallace, Dawn

doi:10.1016/j.poly.2004.10.002

Cited by 51 publications

(32 citation statements)

References 42 publications

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“…[7][8][9] The flexible coordination behavior of these types of chelating ligands could also be useful to generate interesting dimeric and polymeric structures as synthones for supramolecular chemistry. 10,11) Usually, the N, O donor heterodentate Schiff bases can be derived by condensing the aldehydes/ketones with various amines or amino acids.…”

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confidence: 99%

“…[1][2][3][4][5][6] Additionally, tetradentate Schiff bases composed of N 2 O 2 donor atoms set have been recognized as a kind of important chelating ligands for designing medicinally and catalytically useful metal complexes. [7][8][9] The flexible coordination behavior of these types of chelating ligands could also be useful to generate interesting dimeric and polymeric structures as synthones for supramolecular chemistry. 10,11) Usually, the N, O donor heterodentate Schiff bases can be derived by condensing the aldehydes/ketones with various amines or amino acids.…”

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confidence: 99%

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Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Schiff bases have a variety of applications in biological, clinical, and pharmacological areas. The synthesis and application of Schiff bases and their coordination compounds have been highly considered in inorganic, organic and biological fields, since their structural properties similar to some of the biological systems.1-6) Additionally, tetradentate Schiff bases composed of N 2 O 2 donor atoms set have been recognized as a kind of important chelating ligands for designing medicinally and catalytically useful metal complexes. [7][8][9] The flexible coordination behavior of these types of chelating ligands could also be useful to generate interesting dimeric and polymeric structures as synthones for supramolecular chemistry. 10,11) Usually, the N, O donor heterodentate Schiff bases can be derived by condensing the aldehydes/ketones with various amines or amino acids. 12,13) N 2 O 2 Schiff base ligands derived from salicylald ehyde and diamine have been known. 14,15) Dialdehydes and diketones with amines and amino acids have also been utilized to obtain a variety of N 2 O 2 Schiff base ligands. 16)Amino acids plays an important role in many physiological activities of the human body and also helpful in understanding biological functions of macromolecules such as proteins. 17) In particular, tryptophan (Trp)/histidine (His) analogues as promising candidates for novel antimicrobial therapeutics. In the recent years, a series of synthetic peptide analogues based on Trp-His and His-Arg (antimicrobial peptides) structural frameworks have been prepared and found to be active against several Gram-positive and Gram-negative bacterial strains as well as against fungal strains.18) Furthermore, it is well known that the human body contains essential metaloelements which play important roles and interact with many biological molecules to fully understand the physiological functions by studying their chemistry coordination and behavior. 17,18) In the present studies we have introduced an azomethine (Schiff base) linkage to tryptophan/histidine, which may permit a variety in their coordination behaviour and complexation role.In previous studies, we have described the synthesis, catalytic and biological applications of Schiff bases and their metal complexes derived from o-phthalaldehyde (OPA) with various amines. [19][20][21][22][23][24][25][26][27] In this respect, we have also developed some useful macrocyclic Schiff bases and their metal complexes. Results from these studies have also shown that complexation of metals with Schiff base ligands serves to improve their antimicrobial activity. There are few other research groups also reported the importance of Schiff base chemistry of the combination of o-phthalaldehyde with amines.28,29) However, a careful literature survey reveals that Schiff bases from the combination of amino acids and o-phthalaldehyde and their coordination behavior towards the transition elements have yet not been studied. The combination of dialdehyde i.e. o-phthalaldehyde and aminoacids is expected to ...

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Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The biochemical process which involves the condensation of a primary amine in an enzyme may be one of the most important catalytic mechanisms kinds [1]. Transition metal complexes with different oxidation states have a strong role in bioinorganic chemistry and may give the models basis for active sites of biological systems [2][3][4]. For a long time, it had been identified as a serious cofactor in biological compounds, either as a compositional template in protein folding or as a Lewis acid catalyst which can readily adopt the coordination numbers 4, 5, or 6 [5,6].…”

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confidence: 99%

Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde

Alturiqi

Alaghaz

Ammar

et al. 2018

Journal of Chemistry

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Coordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. Elemental analytical data, IR, NMR ( 1 H, 13 C, and 15 N), EPR, XRD, SEM, TEM, EDX, TGA, mass, molar conductance, magnetic moment, and UV-Visible spectra techniques were used to confirm the structure of the synthesized chelates. According to the data obtained, the composition of the 1 : 1 metal ions : furan Schiff base ligand was found to be [M(MFMAQ)Cl 2 ] (M = Cr(III) and Ru(III)) and [M(MFMAQ)Cl(H 2 O)]⋅nH 2 O in which (M = Mn(II); = 1, Co(II); = 0, Ni(II); = 2, Cu(II); = 0 and Zn(II); = 2.5). The measurements of magnetic susceptibility, ligand field parameter, and reflectance spectra suggested an octahedral geometry for the complexes. Central metals ions and furan Schiff base coordinated via O3 and N donor sites which was observed from IR spectra. The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.

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“…Schiff base ligand is considered as a trendiest base because of its various applications like catalytic, optical, electronic, antibacterial, antifungal, antiviral, anti-inflammatory, and antitumor activities [1][2][3][4][5]. Transition metals play a more important role in drug design because of their biologically active metal ions and ligands [6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

Saleem

Sankarganesh²,

Jose

et al. 2017

Journal of Chemistry

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A new pyrimidine based Schiff base ligand (HL) and its four complexes of type [MLOAc]⋅ H 2 O (Cu(II), 1; Zn(II), 2; Co(II), 3; and Ni(II), 4) have been synthesized and characterized by elemental analysis, MS, 1 H-NMR, FT-IR, UV-visible, and ESR techniques. The electronic and ESR spectral data suggested that complexes 1-4 possess square planar geometry. Antimicrobial activities of HL and complexes 1-4 were tested against four bacteria (Staphylococcus aureus, Staphylococcus pneumonia, Salmonella enterica typhi, and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus niger). These results show that complexes 1-4 have good antimicrobial activity compared to HL. The DNA cleavage activity of HL and complexes 1-4 was monitored by the agarose gel electrophoresis method. The antioxidant property of the prepared compounds was assessed by using 2,2 -diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. DNA binding properties of HL and complexes 1-4 have been investigated by electronic absorption technique and viscometric measurements.

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Coordination geometry of tetradentate Schiff’s base nickel complexes: the effects of donors, backbone length and hydrogenation

Cited by 51 publications

References 42 publications

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde

Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

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