Coordination of gastric and gallbladder emptying after ingestion of a regular meal

Lawson, Michael J.; Everson, Gregory T.; Klingensmith, William C.; Kern, Fred

doi:10.1016/0016-5085(83)90437-7

Cited by 61 publications

(24 citation statements)

References 13 publications

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“…3, 4, 23, 24, 25, 26, 27, 28, 29 In recent years, MRI has been shown to measure serially the emptying of the gall bladder accurately, non-invasively and with high spatial resolution. 30, 31, 32, 33, 34 In these studies, serial MRI performed well and it was an effective, non invasive and accurate way of monitoring the effects of various food products on gall bladder emptying.…”

Section: Discussionmentioning

confidence: 99%

“…2 This process is mostly regulated by the hormone cholecystokinin (CCK) that is released by the proximal intestine in response to products of macronutrients digestion, particularly fat. 3, 4, 5, 6, 7, 8 Although there is good knowledge of other secretory responses to dietary composition, such as pancreatic exocrine secretion, the effect of various food ingredients on gall bladder emptying has been explored to a much lesser extent. Specific food ingredients could be effective to trigger gall bladder emptying including dietary protein that stimulates CCK secretion, 9, 10 curcumin that increases gall bladder emptying 11 and protease inhibitors that potentiate the CCK response to nutrients.…”

Section: Introductionmentioning

confidence: 99%

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Effects of various food ingredients on gall bladder emptying

et al. 2013

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Background/objectives:The emptying of the gall bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in contracting the gall bladder postprandially is not well understood. We hypothesized that different food ingredients, when consumed, will have a different effect on stimulating gall bladder emptying. To investigate this we designed two randomized, investigator-blind, cross-over studies in healthy subjects using magnetic resonance imaging (MRI) to measure gall bladder volumes serially and non-invasively.Subjects/methods:Study 1: exploratory study evaluating the effects of 10 different food ingredients on gall bladder emptying in eight healthy subjects. The choice of ingredients varied from common items like coffee, tea and milk to actives like curcumin and potato protease inhibitor. Study 2: mechanistic study investigating the cholecystokinin (CCK) dose response to the best performer ingredient from Study 1 in 21 healthy subjects four ways.Results:The largest gall bladder volume change in Study 1 was observed with fat, which therefore became the dose-response ingredient in Study 2, where the maximum % gall bladder volume change correlated well with CCK.Conclusions:These serial test-retest studies showed that the fasted gall bladder volume varied remarkably between individuals and that individual day-to-day variability had wide coefficients of variation. Improved knowledge of how to stimulate bile release using food ingredients will be useful to improve in vitro–in vivo correlation of bioavailability testing of hydrophobic drugs. It could improve performance of cholesterol-lowering plant stanol and sterol products and possibly aid understanding of some cholesterol gallstone disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of various food ingredients on gall bladder emptying

et al. 2013

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“…The pathophysiological mechanisms of disturbed GB function also remain to be determined, for example, the presence 3,4 or absence 6 of disturbed exocrine pancreatic function and postprandial cholecystokinin (CCK) secretion, and GB responsiveness 2 . The gastric emptying of a liquid meal has been shown to be faster in CP patients 1,7,8 than in healthy controls, but some reports have shown inverted results; 9,10 exocrine pancreatic output disturbance was proposed to be the cause of this dysmotility 1,7 . Although gastric emptying has been shown to be closely related to GB contraction (GBC), 8 previous studies have examined only the single organ and have not considered the effect of other organs.…”

Section: Introductionmentioning

confidence: 99%

“…The gastric emptying of a liquid meal has been shown to be faster in CP patients 1,7,8 than in healthy controls, but some reports have shown inverted results; 9,10 exocrine pancreatic output disturbance was proposed to be the cause of this dysmotility 1,7 . Although gastric emptying has been shown to be closely related to GB contraction (GBC), 8 previous studies have examined only the single organ and have not considered the effect of other organs. Therefore, the pathophysiological mechanism of gastrobiliary dysmotility in CP remained unclear.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic enzyme supplement improves dysmotility in chronic pancreatitis patients

Mizushima

Ochi

Ichimura

et al. 2004

J of Gastro and Hepatol

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“…The static compliance of the gall bladder, measured by pressure volume relationships, takes [12][13][14][15][16] hours to adjust to the volume of the organ." Over shorter periods of two to four hours compliance remains relatively constant despite large fluctua-tions in volume."…”

mentioning

confidence: 99%

Biliary motility.

Grace¹,

Poston²,

Williamson³

1990

Gut

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The delivery ofbile to the duodenum depends on hepatic secretion of bile plus onward propulsion through the biliary tract. Biliary kinetics involve a series of complex interrelationships between gall bladder, cystic duct, common bile duct, sphincter of Oddi and upper small intestine, with control modulation by various neural and hormonal agents. The application of modern techniques to the study of biliary motility has allowed a composite physiological picture to emerge. Moreover, alterations in biliary motility are increasingly implicated in the aetiology of gall stones and postcholecystectomy symptoms. The present review examines recent developments in the understanding of biliary motility and discusses the detailed events involved in delivering bile to the duodenum.

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Coordination of gastric and gallbladder emptying after ingestion of a regular meal

Cited by 61 publications

References 13 publications

Effects of various food ingredients on gall bladder emptying

Effects of various food ingredients on gall bladder emptying

Pancreatic enzyme supplement improves dysmotility in chronic pancreatitis patients

Biliary motility.

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