Pancreatic enzyme supplement improves dysmotility in chronic pancreatitis patients

Abstract

It was demonstrated that the oral pancreatic enzymes improved the gastric dysmotility, confirming the previous findings that suggested the depleted pancreatic enzyme output caused the dysmotility.

Emerging Approaches for the Treatment of Fat Malabsorption Due to Exocrine Pancreatic Insufficiency

“…In yet other studies, increased cholesterol absorption and improved enterohepatic cycling of bile salts have been reported (Dutta et al, 1986;Vuoristo et al, 1992). Moreover, it has been demonstrated that improvement of lipid digestion contributes to effective correction of motility disorders (Mizushima et al, 2004). Altered levels of gastro-intestinal hormones were normalized (Nustede et al, 1991); accelerated gastric emptying and abnormal antroduodenal motility were corrected (Layer et al, 1997).…”

Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis

“…4,5 And finally, CP patients are believed to have a defect in ileal mucosal absorption of bile salts, effectively reducing the availability of bile salts for enterohepatic circulation. 6 A final factor contributing to pancreatic steatorrhea is the presence of neurohormonal disturbances resulting in gallbladder hypomotility and accelerated gastric and intestinal transit [7][8][9] (see section on Motility).…”

“…32 Abnormal motility patterns in CP patients include accelerated gastric emptying, 7,33 altered post-prandial antroduodenal motility, 9 and alterations in gallbladder motility (delayed gallbladder contraction and reduced gallbladder emptying). 7,8 The severity of these abnormalities is often related to the degree of PEI and their presence often compounds the maldigestion and abdominal discomfort associated with CP.…”

“…PES therapy is effective in normalizing the altered levels of GI hormones, 7,34 and correcting accelerated gastric emptying 7,33 and abnormal antroduodenal motility. 8,35 The normalization of such motility disorders may be attributed to improved lipid digestion and ileal braking induced by breakdown products such as oleic acids, triglycerides and short chain fatty acids.…”

“…Improvement in gallbladder contraction with PES has been demonstrated in some studies 36,37 but not in others. 7 …”