Coordination of injectable self-healing hydrogel with Mn-Zn ferrite@mesoporous silica nanospheres for tumor MR imaging and efficient synergistic magnetothermal-chemo-chemodynamic therapy

Wang, Chun-Yao; Zhao, Nuoya; Huang, Yixuan; He, Ran; Xu, Sicheng; Yuan, Weizhong

doi:10.1016/j.cej.2020.126100

Cited by 59 publications

(24 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nanoparticles also exhibited T2-weighted magnetic resonance imaging contrast enhancement. The Dox loaded self-healing hydrogel was found to impart excellent theragnostic property by providing tumor diagnosis and efficiently synergistic magnetothermal-chemo/chemodynamic therapy [151].…”

Section: Hybrid Polymeric Self-healing Hydrogels As Drug Delivery Platforms For Anti-cancer Therapymentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

View full text Add to dashboard Cite

Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

show abstract

Section: Hybrid Polymeric Self-healing Hydrogels As Drug Delivery Platforms For Anti-cancer Therapymentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

View full text Add to dashboard Cite

show abstract

“…In another paradigm that combined trimodal CDT, magnetothermal therapy, and CHT, Rhodamin B isothiocyanate (RBITC)labeled mesoporous silica nanospheres with an Mn-Zn ferrite (Mn 0.6 Zn 0.4 Fe 2 O 4 ) nanoparticle core (MMSN-RBITC) were introduced into a self-healing hydrogel with loading chemotherapeutic drugs for high effective synergistic magnetothermal-chemo-chemodynamic antitumor activity. 185 Recently, the combination of PTT with magnetothermal therapy has been also widely explored by researchers. In a design, a GOxcontaining sodium alginate (ALG)-Fe 3+ (MAF) hydrogel was applied to encapsulate MoS 2 nanosheets.…”

Section: ■ Chemo-phototherapymentioning

confidence: 99%

“…In light of these points, synergistic magnetothermal and chemodynamic treatment was a promising anticancer approach with high therapy efficiency and low damage to normal tissues. In another paradigm that combined trimodal CDT, magnetothermal therapy, and CHT, Rhodamin B isothiocyanate (RBITC)-labeled mesoporous silica nanospheres with an Mn-Zn ferrite (Mn 0.6 Zn 0.4 Fe 2 O 4 ) nanoparticle core (MMSN-RBITC) were introduced into a self-healing hydrogel with loading chemotherapeutic drugs for high effective synergistic magnetothermal-chemo-chemodynamic antitumor activity . Recently, the combination of PTT with magnetothermal therapy has been also widely explored by researchers.…”

Section: Cdt/magnetothermal Therapy Cdt/magnetothermal Therapy/chtmentioning

confidence: 99%

Polymeric Matrix-Based Nanoplatforms toward Tumor Therapy and Diagnosis

Zhu

Loh

et al. 2021

ACS Materials Lett.

View full text Add to dashboard Cite

show abstract

“…Up to now, nanomaterials have been greatly employed as nanoagents for versatile nanomedical theranostics in light of inherent performances of different therapy modals [ 5 , 6 ]. Taking advantages of superior photothermal, electronic, optical, catalytic, magnetic, physical, and chemical features, these nanomaterials have been widely explored in various therapeutic modals, such as chemotherapy (CHT) [ 7 , 8 ], photothermal therapy (PTT) [ [9] , [10] , [11] ], photodynamic therapy (PDT) [ [12] , [13] , [14] , [15] ], chemodynamic therapy (CDT) [ [16] , [17] , [18] ], magnetothermal therapy [ 19 , 20 ], immunotherapy [ [21] , [22] , [23] ], radiotherapy (RT) [ 24 , 25 ], gene therapy [ 26 , 27 ] and starvation therapy (ST) [ 28 ]. However, non-cancer treatment has a number of disadvantages when used alone, including long-term accumulation, high toxicity, instability and low bioavailability, limiting their future clinic application.…”

Section: Introductionmentioning

confidence: 99%