Coordination responsive tellurium-containing multilayer film for controlled delivery

Abstract

A coordination-responsive tellurium containing film was fabricated for controlled release. The coordination chemistry between telluride molecules and cisplatin was utilized for the loading of cisplatin, while competitive ligands were used for triggered release. This work could enrich the coordination responsive system and further tune the release kinetics of cisplatin.

Selenium/tellurium containing polymer materials in nanobiotechnology

“…The release kinetics could be further modulated by the different competitive ligands such as spermine and spermidine (Fig c). Copyright 2015 Royal Society of Chemistry [71]. [72].…”

Near-infrared light stimuli-responsive synergistic therapy nanoplatforms based on the coordination of tellurium-containing block polymer and cisplatin for cancer treatment

“…The ABA type block copolymer PEG-PUTe-PEG was synthesized through a threestep reaction according to the method described in our previous work. [35] 1 H NMR measurement confirmed the successful synthesis of PEG-PUTe-PEG block copolymer (Figure 1) and the molecular weight (M n ) was 83 k. The coordination interaction between tellurium and platinum was investigated by 1 H NMR and X-ray photoelectron spectroscopy (XPS) with tellurium-containing monomer, di-(1hydroxylundecyl) telluride (denoted as M-Te-OH), as the model compound first. 1 H NMR characterizations (Figure 2A) showed that, 2.6 ppm peaks from the α protons of Te atom were gradually shifted to 2.9 ppm after the complex formation.…”

“…[30][31][32] The coordination chemistry between platinum and tellurium opens new opportunities for platinum-based drugs delivery and endows the tellurium-containing polymers with great potential in platinum drugs delivery and controlled drug release in vivo. [33][34][35][36] Indocyanine green (ICG), a near-infrared tricarbocyanine dye, has obtained approval from the US Food and Drug Administration (FDA) as a clinical diagnostic and imaging agent. Because of the remarkable near-infrared optical features within the optimized light-transparent window of biomedical applications, ICG has been intensively studied for photodynamic therapy (PDT) and photothermal therapy (PTT) in tumor treatment.…”

Tellurium‐Containing Polymers: Towards Biomaterials and Optoelectronic Materials

“…It is hoped that by shortening the diffusion distance of competitive ligands and released platinum, the release period can also be reduced. Therefore, besides the solution system, we have also developed coordination‐responsive films on a surface for a shorter diffusion distance (Figure a) . In this regard, 8,8′‐tellurodioctanoic acid (denoted M‐TeCOOH) is utilized to coordinate with cisplatin and its self‐assembled aggregates are employed as negatively charged building blocks; the positively charged component is a diazo resin (DAR).…”