Copaiba oil enhances <i>in vitro/in vivo</i> cutaneous permeability and <i>in vivo</i> anti-inflammatory effect of celecoxib

Quiñones, Oliesia Gonzalez; Hossy, Bryan Hudson; Pádua, Tatiana Almeida; Miguel, Nádia Campos de Oliveira; Rosas, Elaine Cruz; Ramos, Mônica Freiman de Souza; Pierre, Maria Bernadete Riemma

doi:10.1111/jphp.12906

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…Karpanen et al (2010), presented that the use of EO, which has antimicrobial activity, in a formulation increases the penetration of chlorhexidine as well as its antimicrobial activity. Similarly in another study adding 25% copaiba oil to the formulation increased both the penetration and antiinflammatory activity of celecoxib (Quiñones et al 2018).…”

Section: In Vitro Skin Permeation Studymentioning

confidence: 79%

Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis

Kakadia

Conway

2022

Pharmaceutical Development and Technology

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The skin acts as physical barrier to protect the body from external physical and chemical environment. When skin is infected, the outer epidermal barrier is compromised and colonized with microbial growth. Wound infection presents an immense burden in healthcare costs and decreased quality of life for patients. Topical application of nanoemulsions (NE) at pathological sites offers the potential advantage of direct drug delivery to the skin including potential for follicular targeting. This may have application in the improvement of skin antisepsis. In this study, NEs of triclosan (TSN) were prepared using hot high shear homogenization followed by ultrasonication. The oil phases comprised eucalyptus oil (EO) and olive oil (OO) and pseudo-ternary phase diagrams used to select optimum concentrations of surfactant. EO-based NEs had smaller droplet size and higher entrapment efficiency compared to OO-based NEs. Skin permeation was higher for EO-containing formulations, likely due to higher solubility of TSN in EO, smaller droplet size, low viscosity, and permeation enhancement effects of EO. Significantly, TSN was retained within the skin, demonstrating the potential of NEs for targeting hair follicular delivery within the skin, which may help improve the success of topical antisepsis.

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Section: In Vitro Skin Permeation Studymentioning

confidence: 79%

Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis

Kakadia

Conway

2022

Pharmaceutical Development and Technology

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“…The benefits of Chls in PDT treatment can be harnessed through emulsions containing oil drops (emulgels), which provide preferential means of PS monomerizing. In this process, copaiba oil (CO) offers advantages in skin treatment, due to its cell regeneration properties [23][24][25][26][27], as widely recognized in popular culture. CO from the Copaifera reticulata genus is rich in sesquiterpenes and diterpene compounds [28].…”

Section: Introductionmentioning

confidence: 99%

Photo-Phytotherapeutic Gel Composed of Copaifera reticulata, Chlorophylls, and k-Carrageenan: A New Perspective for Topical Healing

et al. 2022

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Chronic wound healing represents an impactful financial burden on healthcare systems. In this context, the use of natural products as an alternative therapy reduces costs and maintains effectiveness. Phytotherapeutic gels applied in photodynamic therapy (PDT) have been developed to act as topical healing medicines and antibiotics. The bioactive system is composed of Spirulina sp. (source of chlorophylls) and Copaifera reticulata oil microdroplets, both incorporated into a polymeric blend constituted by kappa-carrageenan (k-car) and F127 copolymer, constituting a system in which all components are bioactive agents. The flow behavior and viscoelasticity of the formulations were investigated. The photodynamic activity was accessed from studies of the inactivation of Staphylococcus aureus bacteria, the main pathogen of hospital relevance. Furthermore, in vivo studies were conducted using eighteen rabbits with dermatitis (grade III and IV) in both paws. The gels showed significant antibiotic potential in vitro, eliminating up to 100% of S. aureus colonies in the presence or absence of light. The k-car reduced 41% of the viable cells; however, its benefits were enhanced by adding chlorophyll and copaiba oil. The animals treated with the phytotherapeutic medicine showed a reduction in lesion size, with healing and re-epithelialization verified in the histological analyses. The animals submitted to PDT displayed noticeable improvement, indicating this therapy’s viability for ulcerative and infected wounds. This behavior was not observed in the iodine control treatment, which worsened the animals’ condition. Therefore, gel formulations were a viable alternative for future pharmaceutical applications, aiming at topical healing.

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“…Despite the number of anti-inflammatory and analgesic drugs available in the market, the treatment schedules of these clinical conditions are complex and pose huge challenges to the health systems worldwide [24,25]. is scenario points out the urgent need for the development of effective analgesic and anti-inflammatory drugs [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Action andIn VivoAnti-Inflammatory and Antinociceptive Activities ofMyrciaria floribundaFruit Peels: Possible Involvement of Opioidergic System

Santos

Oliveira

et al. 2020

Advances in Pharmacological and Pharmaceutical Sciences

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This work evaluated the antioxidant properties and in vivo antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of Myrciaria floribunda (H. West ex Willd.) O. Berg (Myrtaceae). This plant is popularly known in Brazil as Cambuí or camboim. Different extracts were submitted to comparative analysis to determine the content of selected phytochemical classes (levels of total phenols, flavonoids, and monomeric anthocyanins) and the in vitro antioxidant potentials. The extract with higher potential was selected for in vivo evaluation of its antinociceptive and anti-inflammatory action. Finally, the chemical characterization of this extract was performed by high-performance liquid chromatography (HPLC). MfAE (extract obtained using acetone as solvent) showed the higher levels of phenols (296 mg GAE/g) and anthocyanins contents (35.65 mg Cy-3-glcE/g) that were associated with higher antioxidant activity. MfAE also exhibited in vivo anti-inflammatory and analgesic propertiers. This fraction inhibited the inflammatory and neurogenic phases of pain, and this effect was reversed by naloxone (suggesting the involvement of opioidergic system). MfAE reduced the abdominal contortions induced by acetic acid. The HPLC analysis revealed the presence of gallic acid (and its derivatives) and ellagic acid. Taken together, these data support the use of M. floribunda fruit peels for development of functional foods and nutraceutics.

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Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib

Abstract: 25% C.O is a potential penetration enhancer for lipophilic drugs like Cxb that can improve cutaneous drug penetration and its anti-inflammatory activity.

Cited by 6 publications

References 57 publications

Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis

Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis

Photo-Phytotherapeutic Gel Composed of Copaifera reticulata, Chlorophylls, and k-Carrageenan: A New Perspective for Topical Healing

Antioxidant Action andIn VivoAnti-Inflammatory and Antinociceptive Activities ofMyrciaria floribundaFruit Peels: Possible Involvement of Opioidergic System

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