2020
DOI: 10.1016/j.intimp.2019.106177
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Copaiba oil suppresses inflammation in asthmatic lungs of BALB/c mice induced with ovalbumin

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Cited by 12 publications
(19 citation statements)
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“…As confirmed by the histomorphometric and histopathological analyses, CO induced a significant decline in the number of inflammatories infiltrating in the lung tissue, such as in the parenchyma region. Furthermore, the findings show advantageous immunomodulatory effects of CO in asthmatic rats 58 …”
Section: Resultsmentioning
confidence: 74%
“…As confirmed by the histomorphometric and histopathological analyses, CO induced a significant decline in the number of inflammatories infiltrating in the lung tissue, such as in the parenchyma region. Furthermore, the findings show advantageous immunomodulatory effects of CO in asthmatic rats 58 …”
Section: Resultsmentioning
confidence: 74%
“…Finally, it is important to highlight that, even with these observed variations, the main bioactive molecules of the Copaifera genus are presented, assuring their identity, as they have been previously studied by our research group. In addition, the biological effect of these identified compounds suggests the use of this oil for the treatment of inflammatory disorders, as described by Caputo et al (2020) in a model of pulmonary inflammation and by Ghizoni et al (2017) in a model of arthritis [ 24 , 25 , 26 ].…”
Section: Resultsmentioning
confidence: 99%
“…The results of the pulmonary airspace area (white) were expressed as a percentage [ 24 ]. This involved defining the scale of the images (200 µm) to allow for the measurement of the distance from the airspaces or pulmonary parenchyma (depending on what is to be analyzed), converting them later into 8-bit (in gray-scale) and applying threshold to the images, using the black and white (B&W) tool to limit the intensity of the colors in the histopathological samples in front of the areas of interest (white tone for the airspace, including alveoli, alveolar, and bronchioles; black for the parenchyma pulmonary).…”
Section: Methodsmentioning
confidence: 99%