Copd

Bruce, Maureen L.; McEvoy, P

doi:10.1097/01.npr.0000298268.78149.50

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…In addition, the likelihood of a second event may be related to therapy used for an initial exacerbation [11] or non-resolution of the systemic inflammatory response [12]. Acute exacerbations occur more often in winter [13, 14] and accelerate disease progression [6]. …”

Section: Introductionmentioning

confidence: 99%

Exacerbations of Chronic Obstructive Pulmonary Disease

Garvey¹,

Ortiz²

2012

Open Nurs J

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Epidemiologic data indicate that chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality. Patients with poorly managed COPD are likely to experience exacerbations that require emergency department visits or hospitalization—two important drivers contributing to escalating healthcare resource use and costs associated with the disease. Exacerbations also contribute to worsening lung function and negative outcomes in COPD. The aim of this review is to present the perspective of nurse practitioners and physician assistants in terms of providing the pharmacologic and non-pharmacologic modalities needed to treat current and prevent future exacerbations. Major respiratory guidelines recommend treatment of acute exacerbations with short-acting bronchodilators, oral corticosteroids and antibiotics, as appropriate. Supplementary oxygen and/or ventilatory support may also be beneficial to selected patients. Treatments to minimize the risk of future exacerbations should include maintenance pharmacotherapies, risk-reduction measures (e.g. smoking cessation, influenza and pneumonia vaccinations), pulmonary rehabilitation, self-management support and follow-up care.

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Section: Introductionmentioning

confidence: 99%

Exacerbations of Chronic Obstructive Pulmonary Disease

Garvey¹,

Ortiz²

2012

Open Nurs J

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Identification of MMP-9 as a biomarker for detecting progression of chronic obstructive pulmonary disease

El-Fatah

Ghazy

Mostafa

et al. 2015

Biochem. Cell Biol.

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Chronic obstructive pulmonary disease (COPD) is a complex immunological disease with multiple pathological features that is primarily induced by smoking together with additional genetic risk factors. COPD is frequently underdiagnosed; forced expiratory volume in the first second (FEV1) is considered to be the main diagnostic measure for COPD, yet it is insufficiently sensitive to monitor disease progression. Biomarkers capable of monitoring COPD progression and severity are needed. In this report, we evaluated matrix metalloproteinase-9 (MMP-9) as an early marker for the detection and staging of COPD, by assessing the mRNA levels of MMP-9 in peripheral blood samples collected from 22 COPD patients, 6 asymptomatic smokers, and 5 healthy controls. Our results demonstrate that the mRNA levels of MMP-9 increased more than two-fold in severe COPD relative to non-COPD smokers or moderate COPD groups. Moreover, in the very severe COPD group, MMP-9 mRNA levels showed a 4-fold increase relative to the non-COPD smokers or the moderate COPD groups, while there was a mild increase (∼40%) when compared to the severe COPD group. Taken together, our results suggest that MMP-9 serves as a biomarker for the grade and severity of COPD.

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On the question of dental implantation follow-up and results assessment in patients with risk factors

Seregin

2016

Stomat.

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Copd

Cited by 3 publications

References 3 publications

Exacerbations of Chronic Obstructive Pulmonary Disease

Exacerbations of Chronic Obstructive Pulmonary Disease

Identification of MMP-9 as a biomarker for detecting progression of chronic obstructive pulmonary disease

On the question of dental implantation follow-up and results assessment in patients with risk factors

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