Copolymer/graphene oxide nanocomposites as potential anticancer agents

Rahdar, Abbas; Hajinezhad, Mohammad Reza; Hamishekar, Hamed; Ghamkhari, Aliyeh; Kyzas, George Z.

doi:10.1007/s00289-020-03354-6

Cited by 22 publications

(13 citation statements)

References 65 publications

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“…As established earlier, nanoformulations of Cis have less systemic toxicity and provide tumor-specific effects as compared with the bulk forms of Cis [3,38]. The anticancer and hepatotoxicity of different nanoformulations of drugs have been investigated as molecular nano-theranostic agents [39][40][41]. Cis encapsulation in micelles or nanoemulsions has resulted in increased therapeutic efficacy and anti-cancer efficiency [38].…”

Section: Biochemical Analysismentioning

confidence: 99%

F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies

et al. 2021

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The development of effective strategies for local administration of chemotherapeutic drugs, thus minimizing the adverse side effects to patients, is one of the key challenges in biomedicine and cancer research. This work reports the formulation and characterization of PluronicF127 microemulsions to enhance the bioavailability of Cisplatin (Cis). The size of Cis microemulsion was about 12.0 nm, as assessed by dynamic light scattering analysis. In vitro cytotoxic activity of free Cis and F127/Cis microemulsions were studied on malignant (C152 and MCF7) and normal (HUVEC) cells via tetrazolium (MTT) colorimetric assay. Cell morphology was also monitored. In vitro assessments revealed thatF127/Cis microemulsions induced cytotoxicity/morphological changes to a lesser extent than free Cis. Regarding in vivo experiments, F127/Cis microemulsions were injected intraperitoneally at 7 and 14 mg/kg doses into adult male Wistar rats to assess histologic and biochemical changes. In this case, the bulk Cis group caused severe histopathological changes and significant increases in serum liver enzymes and serum kidney function markers. The group treated with the 14 mg/kg dose of F127/Cis microemulsions also showed severe fatty changes and significant increases in serum liver enzymes, blood urea nitrogen, and creatinine levels. The group treated with the low dose of nano-Cis showed a significant increase in serum liver enzymes levels accompanied by mild fatty changes of the liver. Theoretical surveys were performed to get an understanding of the interplay between F127 and Cis. Results reveal that hydrogen bonding (HB) interactions with F127have an influence on the molecular properties of Cis and may playa role in the lower toxicity of F127/Cis in comparison to free Cis.

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Section: Biochemical Analysismentioning

confidence: 99%

F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies

et al. 2021

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“…PEG-coated GO encapsulating erlotinib ( Figure 11 ) strongly suppressed proliferation, migration, and invasion of nasopharyngeal carcinoma (NPC) cells and may be used as a potential therapeutic agent for treating NPC [ 195 ]. As a safe nanovehicle for DOX delivery in cancer therapy, a GO/PEG-b-poly(2-hydroxyethyl methacrylate- g -lactide) 2 nanocomposite was also reported [ 196 ].…”

Section: Graphene Oxidementioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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“…With this in mind, as a continuous effort related to the synthesis of nanomaterials and investigation of their potential in biological applications [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ], we currently review here different nanomaterials applied to diagnosis and treatment of inflammatory arthritis.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

Hosseinikhah

Barani

Rahdar

et al. 2021

IJMS

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Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.

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Copolymer/graphene oxide nanocomposites as potential anticancer agents

Cited by 22 publications

References 65 publications

F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies

F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Nanomaterials for the Diagnosis and Treatment of Inflammatory Arthritis

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