F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies

Sargazi, Saman; Hajinezhad, Mohammad Reza; Barani, Mahmood; Mukhtar, Mahwash; Rahdar, Abbas; Baino, Francesco; Karimi, Pouran; Pandey, Sadanand

doi:10.3390/app11073006

Cited by 20 publications

(7 citation statements)

References 38 publications

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“…Nanoparticles (NPs) have gained interest of scientists in the field of nanomedicine 29 – 36 . The therapeutic effects of NPs depend on the particle size, the culture time of the target cell, the amount of metal in the targeted cell, and their physicochemical properties 36 – 39 . On the other hand, bimetallic and multimetallic NPs have shown unique physicochemical properties with synergistic effects and high functionality 40 .…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties

Cao

Dhahad

El-Shorbagy

et al. 2021

Sci Rep

113

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In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties

Cao

Dhahad

El-Shorbagy

et al. 2021

Sci Rep

113

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“…Intravenous administration of free DOX/PTX showed a slight inhibition of tumor growth. The use of single drug-loaded CaP@Lip NPs was more effective in inhibiting tumor growth than free DOX/PTX, possibly due to the EPR effect. − Under this condition, higher accumulation of the drugs was achieved in the tumor and tumor growth was effectively inhibited. The DOX/PTX-loaded CaP@Lip NPs demonstrated the most significant effect on inhibiting tumor growth, leading to the lowest tumor volume and weight (as shown in Figure B–D) and a remarkable 76% inhibition of tumor growth.…”

Section: Resultsmentioning

confidence: 99%

“…Cancer therapy remains a major medical challenge despite many strategies being developed, such as chemotherapy, photothermal therapy, and radiation therapy. − The concept of cancer treatment strategies based on the enhanced permeability and retention (EPR) effect has gained significant attention. Molecules or particles with specific sizes tend to aggregate in tumor tissues rather than in normal tissues. − Currently, dual-drug delivery (DDD) systems based on silica, polymer micelles, and liposomes nanoparticles (NPs) have been widely reported. − However, when using a single nanomaterial for DDD systems, its function may be limited, and it can be difficult to fully utilize its optimal properties. In contrast, DDD systems that can load and deliver two drugs have proven effective in overcoming drug resistance, reducing toxicity, and enabling combination therapy.…”

Section: Introductionmentioning

confidence: 99%

Calcium Orthophosphate in Liposomes for Co-Delivery of Doxorubicin Hydrochloride/Paclitaxel in Breast Cancer

Chen

Guo

et al. 2023

Mol. Pharmaceutics

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Nanoparticles (NPs) show great advantages in cancer treatment by enabling controlled and targeted delivery of payloads to tumor sites through the enhanced permeability and retention (EPR) effect. In this study, highly effective pH-responsive and biodegradable calcium orthophosphate@liposomes (CaP@Lip) NPs with a diameter of 110 ± 20 nm were designed and fabricated. CaP@Lip NPs loaded with hydrophobic paclitaxel and hydrophilic doxorubicin hydrochloride achieved excellent drug loading efficiencies of 70 and 90%, respectively. Under physiological conditions, the obtained NPs are negatively charged. However, they switched to positively charged when exposed to weak acidic environments by which internalization can be promoted. Furthermore, the CaP@Lip NPs exhibit an obvious structural collapse under acid conditions (pH 5.5), which confirms their excellent biodegradability. The "proton expansion" effect in endosomes and the pH-responsiveness of the NPs facilitate the release of encapsulated drugs from individual channels. The effectiveness and safety of the drug delivery systems were demonstrated through in vitro and in vivo experiments, with a 76% inhibition of tumor growth. These findings highlight the high targeting ability of the drugloaded NPs to tumor sites through the EPR effect, effectively suppressing tumor growth and metastasis. By combining CaP NPs and liposomes, this study not only resolves the toxicity of CaP but also enhances the stability of liposomes. The CaP@Lip NPs developed in this study have significant implications for biomedical applications and inspire the development of intelligent and smart drug nanocarriers and release systems for clinical use.

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“…They are easy to make and can deliver hydrophobic or hydrophilic drugs. [89] They can enter tissues, extend circulation, and interact with bio-nano particles. They can protect the drug from degradation and increase its bioavailability.…”

Section: Nanoemulsionsmentioning

confidence: 99%

Nanotechnology‐Based Strategies for Extended‐Release Delivery of Angiotensin Receptor Blockers (ARBs): A Comprehensive Review

Haji Ali,

Shirvaliloo,

Fathi‐Karkan

et al. 2023

Chemistry & Biodiversity

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There has been a significant shift in the perception of hypertension as an important contributor to the global disease burden. Approximately 6% and 8% of pregnancies are affected by hypertension, which can adversely affect the mother and the fetus. Furthermore, a hypertensive individual is at increased risk of developing kidney disease, arterial hardening, eye damage, and strokes. Using angiotensin receptor blockers (ARBs) is widespread in treating hypertension, heart failure, coronary artery disease, and diabetic nephropathy. Despite this, some ARBs have limited use due to their poor oral bioavailability and water solubility. To tackle this, a variety of nanoparticle (NP)‐based systems, such as polymeric NPs (i.e., dendrimers), polymeric micelles, polymer‐drug conjugates, lipid NPs, nanoemulsions, self‐emulsifying drug delivery systems (SEDDS), solid lipid NPs (SLNs), nanostructured lipid carriers (NLCs), carbon‐based nanocarriers, inorganic NPs, and nanocrystals, have been recently developed for efficient delivery of losartan, Valsartan (Val), Olmesartan (OLM), Telmisartan (TEL), Candesartan, Eprosartan, Irbesartan, and Azilsartan to target cells. This review article provides a literature‐based comparison of the various classes of ARBs, their mechanisms of action, and an overview of the nanoformulations developed for ARB delivery and successfully applied to managing hypertension, diabetic complications, and other conditions.

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F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies

Cited by 20 publications

References 38 publications

Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties

Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties

Calcium Orthophosphate in Liposomes for Co-Delivery of Doxorubicin Hydrochloride/Paclitaxel in Breast Cancer

Nanotechnology‐Based Strategies for Extended‐Release Delivery of Angiotensin Receptor Blockers (ARBs): A Comprehensive Review

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