Copper and immunity

Percival, Susan S.

doi:10.1093/ajcn/67.5.1064s

Cited by 336 publications

(224 citation statements)

References 27 publications

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“…Enhanced clearance of copper may, therefore, reduce PrP Sc formation and/or its stability. The therapeutic effect of the chelator may also be indirect because copper has immunomodulatory effect (32), and the immune system is involved in propagation of prionosis (33).…”

Section: Discussionmentioning

confidence: 99%

Copper Chelation Delays the Onset of Prion Disease

Sigurdsson¹,

Brown

Alim³

et al. 2003

Journal of Biological Chemistry

180

152

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The prion protein (PrP) binds copper and under some conditions copper can facilitate its folding into a more protease resistant form. Hence, copper levels may influence the infectivity of the scrapie form of prion protein (PrP Sc ). To determine the feasibility of copper-targeted therapy for prion disease, we treated mice with a copper chelator, D-(؊)-penicillamine (D-PEN), starting immediately following intraperitoneal scrapie inoculation. D-PEN delayed the onset of prion disease in the mice by about 11 days (p ‫؍‬ 0.002), and reduced copper levels in brain by 29% (p < 0.01) and in blood by 22% (p ‫؍‬ 0.03) compared with control animals. Levels of other metals were not significantly altered in the blood or brain. Modest correlation was observed between incubation period and levels of copper in brain (p ‫؍‬ 0.08) or blood (p ‫؍‬ 0.04), indicating that copper levels are only one of many factors that influence the rate of progression of prion disease. In vitro, copper dose-dependently enhanced the proteinase K resistance of the prion protein, and this effect was counteracted in a dose-dependent manner by co-incubation with D-PEN. Overall, these findings indicate that copper levels can influence the conformational state of PrP, thereby enhancing its infectivity, and this effect can be attenuated by chelatorbased therapy.

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Section: Discussionmentioning

confidence: 99%

Copper Chelation Delays the Onset of Prion Disease

Sigurdsson¹,

Brown

Alim³

et al. 2003

Journal of Biological Chemistry

180

152

View full text Add to dashboard Cite

show abstract

“…Las consecuencias sobre la salud de la deficiencia de zinc y cobre, se producen fundamentalmente como consecuencia de la alteración del sistema inmune 2,4,15,40,41 . En el adulto mayor la situación se hace crítica considerando la disregulación del sistema inmune propia del proceso de envejecimiento 42 , lo que favorecería el aumento de la morbilidad y mortalidad de este grupo poblacional 15 .…”

Section: Prevalencia De Deficiencia De Zn Y Cu En Adultos Mayores -Munclassified

Prevalencia de las deficiencias de zinc y cobre en adultos mayores de la Región Metropolitana de Santiago

et al. 2011

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“…Understanding the survival mechanisms of M. tuberculosis in the human host is key to controlling this devastating disease. In addition to the known mechanisms of the innate and adaptive immune response to infections (2,3), it is increasingly recognized that copper is utilized by macrophages to kill pathogenic bacteria (4,5). In most organisms, copper is used as a cofactor in a variety of enzymes, including cytochrome c oxidases, and is therefore an essential micronutrient (6).…”

mentioning

confidence: 99%