Copper‐based Metal‐organic Framework Applied in the Development of an Electrochemical Biomimetic Sensor for Catechol Determination

Abstract

In this study, the synthesis and characterization of a Cu‐based metal‐organic framework (MOF) [Cu3(BTC)2(H2O)3]n (where BTC=benzene‐1,3,5‐tricarboxylate), known as HKUST‐1, were performed. The Cu‐MOF was applied in the modification of a carbon paste to obtain a biomimetic sensor for the electrochemical determination of catechol. Kinetic assays confirmed that the Cu‐MOF acts as a catalyst for the oxidation of catechol and it can be considered as a catechol oxidase mimetic. Under optimized conditions, the calibration curve for catechol presented a linear range of 8.0×10−7 to 3.2×10−5 mol L−1, with detection limit of=1.0×10−7 mol L−1. The sensor demonstrated good intra‐day repeatability and inter‐electrode reproducibility (relative standard deviations of 3.8 % (n=10) and 4.3 % (n=6), respectively). In the selectivity study, an adequate peak‐to‐peak separation was observed for hydroquinone and uric acid in relation to catechol, demonstrating that this sensor has the potential for use in the simultaneous determination of these compounds. This sensor was successfully applied in the determination of catechol in water samples.

Electrochemical Sensing Platforms of Dihydroxybenzene: Part 2 – Nanomaterials Excluding Carbon Nanotubes and Graphene

“…Owing to their tunable structure, surface topology, and pore size, MOFs have become an interesting functional material for electrochemical sensing applications [57,87] . Brondani et al [87] .…”

“…Owing to their tunable structure, surface topology, and pore size, MOFs have become an interesting functional material for electrochemical sensing applications [57,87] . Brondani et al [87] . constructed an efficient electrochemical sensor for CT detection based on HKUST‐1 (Cu‐based MOF) [Cu 3 (BTC) 2 (H 2 O) 3 ] n (where BTC=benzene‐1,3,5‐tricarboxylate).…”

An electrochemical sensor based on copper-based metal–organic framework-reduced graphene oxide composites for determination of 2,4-dichlorophenol in water

“…15 Ji et al prepare Cu-BTC frameworks as a novel detection platform for sunset yellow and tartrazine. 16 A Cu-MOF/graphene composite has been used for determination of dopamine and paracetamol, 17 Cu-based metal-organic framework [Cu 3 (BTC) 2 (H 2 O) 3 ] n for catechol 18 and MOF 199-GO-n/GCE for catechol and hydroquinone. 19 Dihydroxylbenzene has been detected in water by using an electrochemical sensor based on Cu-MOF-GN composites.…”

First Report for Levodopa Electrocatalytic Oxidation Based on Copper Metal‐Organic Framework (MOF): Application in a Voltammetric Sensor Development for Levodopa in Real Samples

“…[19][20][21] MOFs can also be used as synthetic enzymes in electrochemical sensors and biosensors depending on the structure and the type of metal used. For example, iron-based MOF and Cu (BTC) MOF (BTC: trimesic acid) have shown peroxidase-like activity for electrochemical the detection of H 2 O 2 [28] and catechol [29] respectively. Cu based MOFs, consisting of Cu 2 + ions and ligands such as TPA and BTC, have shown good electrochemical properties and excellent catalytic performance in electrochemical sensors for detection of analytes such as glucose, H 2 O 2 , etc.…”