Copper-Catalyzed Electrophilic Amination: An Umpolung Strategy for New C–N Bond Formations

Abstract

The nitrogen atom is ubiquitous in bioactive molecules and functional materials, and the development of new C–N bond forming strategies is thus one of the long-standing research subjects in the synthetic community. This account describes the nitrogen-umpolung-enabled copper-catalyzed highly chemo- and stereoselective amination protocols developed by the author’s research group. Starting from the C–H amination, electrophilic amination of stable organoboron and organosilicon compounds, aminoboration/hydroamination of alkenes, and their applications to the synthesis of functionality-rich alkylamines are shown. The reaction design, concept, and substrate scope are briefly summarized.

A general Fe-catalysed azidation of iododifluoroketones and its utilization for the synthesis of gem-difluoromethylenated triazoles

“…On the other hand, organic azides, especially the aliphatic ones, are widely found in biologically active pharmaceuticals and synthetically valuable building blocks for the preparation of N-containing frameworks. 9 The development of synthetic strategies for the direct introduction of the azido group to organic molecules and obtaining structurally diverse azides has been one of the long-standing research topics over the past decades. 10 α-Difluoroalkylazides represent one of the most useful precursors for the construction of gem -difluorinated N-containing molecules of functional properties.…”

Materials Nanoarchitectonics at Dynamic Interfaces: Structure Formation and Functional Manipulation

“…Humans have developed various types of chemistry since the 20th century, which has led to modern scientific research. Research on the development of functional systems through organic chemistry [ 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ], inorganic chemistry [ 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ], coordination chemistry [ 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 ], supramolecular chemistry [ 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 ], polymer chemistry [ 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 ], interface chemistry [ 127 , …”

Confined Space Nanoarchitectonics for Dynamic Functions and Molecular Machines

“…The research field of creating and processing materials has developed rapidly since around the 20th century and is still an active research field. Such fields include organic chemistry [59][60][61][62][63], inorganic chemistry [64][65][66][67][68], polymer chemistry [69][70][71][72][73], coordination chemistry [74][75][76][77][78], supramolecular chemistry [79][80][81][82][83], other material sciences [84][85][86][87][88], and biological sciences [89][90][91][92][93]. Detailed control of fine structure is also being carried out.…”