Encyclopedia of Inorganic and Bioinorganic Chemistry 2021
DOI: 10.1002/9781119951438.eibc2691
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Copper Complexes as Anticancer Agents

Abstract: Following the great impetus provided by the discovery of the anticancer activity of cisplatin [ cis ‐diamminedichloridoplatinum(II)] in the 1960s, extensive search for alternative metal‐based drugs with improved pharmacological properties has been attempted. Actually, the outstanding efficacy showed by clinically approved Pt(II) compounds is counterbalanced by severe toxic effects on normal tissues, and by the early appearance of drug resistance phenomena. Among non‐Pt compounds, copper… Show more

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