Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

“…Cu(II) complexes of some organic drugs have been the subject of a number of studies aimed at establishing the presumed synergy between the Cu(II) ion and the drug [36][37][38][39]. In more recent years there have been numerous reports highlighting the significant biological activity of Cu(II) Schiff base complexes [40][41][42][43][44][45][46].…”

Synthesis and spectroscopic characterizations of Cu(II) complexes with novel 15‐membered N4 macrocyclic ligand and their utility to obtain CuO nanostructures for efficient degradation of dyes

“…[1][2][3][4][5] In particular, the involvement of copper in human disease has been described from a both biochemical and a medicinal view. [5][6][7] Studies have concentrated on the biochemical action of Cu(II) complexes with non-steroidal anti-inflammatory drugs, [8] the potential chemotherapeutic properties of Cu-based compounds, [9,10] and the antiviral and antibacterial activity of Cu(II) complexes. [11][12][13] The Cu(II) complexes, exhibiting cytotoxic activity through cell apoptosis or enzyme inhibition, have also been reviewed.…”

In Vivo Bio-Distribution Study of 64Cu (II)-Labelled Copper (II) Complexes of Peptides Mimics in Balb/C Mice-Development of Copper Based Anti-Inflammatory Agents

“…In this study we have synthesized compounds which possess some common properties as those of nitrogen containing bio-functional molecules such as oligopeptides [8]. The benzyl and pyridyl groups in these compounds are mainly found in most of the non-steroidal anti-inflammatory drugs (NSAIDs) and Cu (II)-NSAIDs complexes are reported to be more effective than their parent compounds [9]. We study the bio-distribution of these compounds in mice using 64 Cu (II) as a radiotracer.…”