Copper complexes with bioactive ligands

Abstract

Antifungal activity of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of the composition Cu(2-MeSNic)2(MeNia)(2).4H2O (where MeNia is N-methylnicotinamide), and Cu(2-MeSNic)2(Nia)(2).2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide, iNia, or ethyl nicotinate, EtNic) were tested on various strains of filamentous fungi by the macrodilution method. Most sensitive against copper(II) adducts with bioactive ligands were Rhizopus oryzae and Microsporum gypseum (IC50 1.5-2.3 mmol/L). The adducts with Nia, MeNia and EtNic at 5 mmol/L induced morphological changes in growing hyphae of Botrytis cinerea, mainly their intensive branching attached to release of cytoplasm with partial growth inhibition. Inhibition of sporulation (> 90%) of Alternaria alternata by Cu(2-MeSNic)2.H2O was observed as a change in the color of the colonies. The highest resistance was marked by B. cinerea and Fusarium moniliforme (average IC50 values 4.25 and 3.13 mmol/L, respectively). The presence of all bioactive ligands in copper(II) complexes caused an increase in the inhibition effect against model fungi (except significant inhibition activity of EtNic on R. oryzae).

Grafting of vinyl acetate onto chitosan and biocidal activity of the graft copolymers

“…The found trend of growth inhibition in these complexes was in the order Cu > Ni > Co. 62 Copper complexes with bioactive ligands were tested as antifungal agents against various strains of filamentous fungi. 63 Chohan et al 64 synthesized thiocarbohydrazone, carbohydrazone, thiosemicarbazone, and semicarbazone ligands. These ligands were used for the preparation of Cu(II), Ni(II), Co(II), and Zn(II) metal complexes.…”

Crystal structure, spectroscopic and magnetic properties, and antimicrobial activities of cobalt(II) 2-methylthionicotinate complexes with N-heterocyclic ligands

“…Efficiency of the prepared derivatives on filamentous fungi Rhizopus oryzae, Alternaria alternata (both from the Collection of Microorganisms of Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology STU, Bratislava, Slovakia), Botrytis cinerea CCM F-16 and Microsporum gypseum (from the Laboratory of Medical Mycology, Postgraduate Medical Institute, Bratislava, Slovakia) was observed by macro-dilution technique on solidified broth medium during static culturing [32].…”

New effects and applications of thioflavins

“…The effect of Thioflavin T on the growth of filamentous fungi Rhizopus oryzae CCM 8284, Alternaria alternata CCM F-128 and Microsporum gypseum was observed using a macrodilution technique on Sabouraud-glucose agar (dermatophytes) and malt agar (other fungi) during the static cultivation. The diameters of growing fungal colonies were measured at intervals as previously described [20].…”