Copper-Containing Anti-Biofilm Nanofiber Scaffolds as a Wound Dressing Material

Ahire, Jayesh J.; Hattingh, Melanie; Neveling, Deon P.; Dicks, Leon M. T.

doi:10.1371/journal.pone.0152755

Cited by 76 publications

(49 citation statements)

References 44 publications

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“…Some authors (Heliopoulos et al, 2013) used wool fabric with an alginate and copper ions coating as an antimicrobial agent using the example of E. coli. Ahire et al (2016) investigated in their study the influence of copper nanoparticles that were incorporated into nanofibers during the electrospinning of poly-D,llactide(PDLLA) and poly(ethyleneoxide) on biofilm formation. As a result, it was found that the biofilm formation of P. aeruginosa and S. aureus decreased by 41% and 50%, respectively, due to copper released from the nanofibers.…”

Section: Discussionmentioning

confidence: 99%

“…It is known that nanoparticles reveal new features due to quantum-size effects and, consequently, reactivity and biological activity growth (Khezerlou et al, 2018). In previous works (Borkow et al, 2009;Ahire et al, 2016;Khan & Yaqoob, 2017) the positive effect of nanoparticles of such metals as Cu in connection with bactericidal properties was considered. Disinfectant properties of Cu alloys surfaces were determined but Cu antibacterial activity mechanisms, its antimicrobial properties and ability to impact microbial biofilm formation (Agarwala et al, 2014;Jamal et al, 2018) are still not systematically understood and are only covered in scattered studies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of antimicrobial properties of polymer nanocomposites for medical application

Hopta¹,

Mishyna²,

Syrova³

et al. 2019

Regul. Mech. Biosyst.

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The paper is devoted to the investigation of antimicrobial activity of polymer nanocomposites of both low-density polyethylene and nonwoven polymeric material (a mixture of woven and polyester fibers) that had been impregnated by Cu nanoparticles. The microorganisms were grown according to generally accepted microbiological rules and on media recommended for each bacteria family. Formation of biofilms of microorganisms was studied on the surface of microtiter plates for enzyme-linked immunosorbent assay. After incubation of microtiter plates, the culture medium was removed from the wells. The wells were rinsed five times with sterile distilled water. The plates were air dried for 45 minutes and each well was stained with 1% crystal violet solution in water for 45 min. After staining, the plates were washed with sterile distilled water five times. The quantitative analysis of biofilm production was done by adding 95% ethanol for discoloration of the wells. The research shows the antibacterial activity of Cu nanoparticles on planktonic forms of the investigated microorganisms, which prevented the formation of dense biofilms. With the use of low-density polyethylene impregnated by Cu the ability to form biofilms by planktonic cells of the referent strains of microorganisms was detected to decrease by 1.7 (Escherichia coli), 12.3 (Klebsiella pneumonia) times in the studied strains and with the use of nonwoven polymeric material treated by Cu nanoparticles, the ability to form biofilms decreased by 1.8 (Escherichia coli) – 21.8 (Klebsiella pneumonia) times in the studied strains. In subjecting the formed daily biofilms of referent strains of microorganisms to Cu nanoparticles, the destruction of biofilms of the studied strains of microorganism was observed as well as violation of the integrity of the biofilm monolayer and decrease of density index in comparison with control values. As a result, the obtained polymer nanocomposites can be recommended for preventive use in the fight against nosocomial infections. The practical relevance of this study lies in the possibility of reducing the incidence of purulent-inflammatory diseases and mycoses and, accordingly, reduction of the costs of treating these diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial properties of polymer nanocomposites for medical application

Hopta¹,

Mishyna²,

Syrova³

et al. 2019

Regul. Mech. Biosyst.

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“…Ahire et al incorporated copper nanoparticles into nanofibers through the electrospinning of PEO and Poly-D, L-lactide. After 48 h at the presence of Cu-nanofibers, S. aureus and P. aeruginosa were reduced by 50% and 41%, respectively 89 .…”

Section: Electrospunmentioning

confidence: 98%

Untitled

2019

IJPSR

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This study aimed to introduce antibacterial nanofibers, produced by electrospinning as a novel technique in constructing nanostructured materials. In the electrospinning technique, a high voltage is applied to a polymer solution to overcome the surface tension. A charged polymer jet is ejected to a grounded electrode. As the solvent is evaporated, the electrospun fiber with diameter from micrometer to nanometer is formed. One of the most important features of electrospun nanofibers stated in this paper is their activity as effective carriers of antibacterial substances, which leads to the use of them in many fields such as food packaging, drug delivery, wound healing, filtration, and food sciences. An electrospun nanofiber containing antimicrobial agents indicates excellent antibacterial functions against a wide spectrum of bacteria and sustain the antibacterial activity over a long period. In general, several aspects of antibacterial nanofibers, including synthesize, applications, types of antibacterial agents combined with them such as essential oils, herbal bioactive components, metals, drugs, and peptides have been stated.

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“…Copper particles After 48 h biofilm formation by S. aureus Xen 30 and P. aeruginosa PA01S. was reduced by 50% and 41%, respectively [273] Tissue engineering Poly (l-lactide-co-glycolide)/ (PLGA/PLLA)…”

Section: Vancomycin (Van) Linezolid (Lin) and Daptomycin (Dap)mentioning

confidence: 99%

Nanofibers for Biomedical and Healthcare Applications

Rasouli

Barhoum

Bechelany

et al. 2018

Macromolecular Bioscience

232

112

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Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue‐engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core‐shell nanofibers) fabricated from various materials and their potential biomedical applications.

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Copper-Containing Anti-Biofilm Nanofiber Scaffolds as a Wound Dressing Material

Cited by 76 publications

References 44 publications

Evaluation of antimicrobial properties of polymer nanocomposites for medical application

Evaluation of antimicrobial properties of polymer nanocomposites for medical application

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Nanofibers for Biomedical and Healthcare Applications

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