Copper Deficiency in Ruminants

McMurray, C.H.

doi:10.1002/9780470720622.ch10

Novartis Foundation Symposia

1980

DOI: 10.1002/9780470720622.ch10

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Copper Deficiency in Ruminants

C.H. McMurray

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1982

1983

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Cited by 9 publications

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Ceruloplasmin, a copper-transport protein, can act as a growth promoter for some cell lines in serum-free medium

1982

In Vitro

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Ceruloplasmin (Cp) is a copper-transport protein with ferric oxidase activity found in high concentrations in the plasma of all vertebrates. Five cell lines (TR-1, TR-M, TR-ST, TM3, and TM4) derived from the testis can be grown in hormone-supplemented serum-free medium. Cp stimulates the growth of four of these five cell lines in serum-free medium. The growth stimulation by Cp is not affected by the addition or deletion of free copper, nor does copper itself elicit any significant growth response. Cp can stimulate growth also in the absence of TF suggesting that it is not acting solely to promote Fe(III)-TF binding. A strong interaction is seen between Cp and high density lipoprotein (HDL), with the presence of either decreasing the growth-promoting activity of the other. It is suggested that these cell lines may provide an ideal system for studying the action of Cp at the cellular level.

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Ceruloplasmin, a copper-transport protein, can act as a growth promoter for some cell lines in serum-free medium

1982

In Vitro

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Investigation of the effect of copper status and therapy on fertility in beef suckler herds

Phillippo¹,

Humphries²,

Lawrence³

et al. 1982

J. Agric. Sci.

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6.16 Some Advances in Clinical Biochemistry Relating to Trace Metals

et al. 1983

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The clinical signs of copper (Cu) deficiency are largely non-specific and a number of laboratory tests have been used extensively to assist in diagnosis. Among these are whole blood, plasma and serum Cu and caeruloplasmin (McMurray, 1980). However, for any marker to be useful diagnostically, it is necessary to identify any factors which can affect it. Plasma and serum Cu are not equivalent but are related by the equation:Serum Cu (mg/l) = 11.7 + 0.66 plasma Cu (mg/l). The regression was obtained from the means of 24 groups of suckler cows and calves (> 10 animals/group). The equivalent relationship between serum and plasma caeruloplasmin is:Serum caeruloplasmin = 0.0018+ 0.59 plasma caeruloplasmin.Units of caeruloplasmin are absorbance units in the phenylene diamine assay.Thus, the range of normality will depend on the sample being used for the assay. The reduction in serum values is due to the loss of caeruloplasmin during blood clotting.

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Copper Deficiency in Ruminants

Cited by 9 publications

References 72 publications

Ceruloplasmin, a copper-transport protein, can act as a growth promoter for some cell lines in serum-free medium

Ceruloplasmin, a copper-transport protein, can act as a growth promoter for some cell lines in serum-free medium

Investigation of the effect of copper status and therapy on fertility in beef suckler herds

6.16 Some Advances in Clinical Biochemistry Relating to Trace Metals

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