Copper deposited diatom-biosilica with enhanced photothermal and photodynamic performance for infected wound therapy

Cong, Xin; Mu, Yuzhi; Qin, Di; Sun, Xiaoyang; Su, Chang; Chen, Tongtong; Chen, Xiguang; Feng, Chao

doi:10.1039/d1nj05283g

Cited by 9 publications

(16 citation statements)

References 48 publications

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“…The size of DBs varies basically from 5 to 9 μm, and rich attachment sites were provided for Cu metal mineralization and Ce nanoparticles. The organics in the diatom could be removed by a mixture of H 2 SO 4 and H 2 O 2 solution at 70 °C, leaving the inorganic residues composed of highly pure amorphous silica as DBs. − The DBs exhibited a hierarchical porous structure with various pore sizes: the primary sector pore was ∼800 nm in length; the secondary circular pore was 30–50 nm in diameter; the tertiary circular pore was 1–2 nm in diameter. The doping of Cu into DBs was realized by a hydrothermal reaction .…”

Section: Resultsmentioning

confidence: 99%

“…Our method is illustrated in Figure a. To improve the material stability and photocatalytic performance, DBs as a highly porous, light capture, and light absorbing natural silica material was used to prepare an n-type Cu-DBs semiconductor . Then, n-type CeO 2 -NPs were secondary mineralized on the surface of Cu-DBs to form a typical n–n semiconductor heterojunction.…”

Section: Introductionmentioning

confidence: 99%

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Reversible Regulation of the Reactive Oxygen Species Level Using a Semiconductor Heterojunction

Yang

Shao

et al. 2022

ACS Appl. Mater. Interfaces

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Here, we proposed a novel solution for reversible regulation of the reactive oxygen species (ROS) level using a semiconductor heterojunction. Two metal-based ROS scavengers containing n-type CeO2 nanoparticles and n-type Cu-doped diatom biosilica (Cu-DBs) were integrated by a hydrothermal method to form a typical n–n semiconductor heterojunction (Ce/Cu-DBs). Unlike the control of the ROS level by a single ROS scavenger or ROS-generating agent, Ce/Cu-DBs could quickly eliminate ROS by cascade catalytic reaction, which readily switched to ROS generation through a near-infrared (NIR)-triggered photocatalytic effect. This NIR mediated ROS regulation system provided a noninvasive strategy for reversible control of the ROS level in vitro and in vivo. The Ce/Cu-DBs could relieve cellular oxidative stress by clearing local excessive ROS while inhibiting bacterial growth by increasing ROS levels under NIR radiation. Benefiting from the reversible regulatory effect of Ce/Cu-DBs, programmable healing of infected wounds was realized via on-demand anti-infection and inflammation reduction. This work provided a general method with highly spatiotemporal resolution to a remote and sustainable control ROS level, which had great potential for the biomedical field and regulation of chemical reactions.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reversible Regulation of the Reactive Oxygen Species Level Using a Semiconductor Heterojunction

Yang

Shao

et al. 2022

ACS Appl. Mater. Interfaces

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“…This, in turn, resulted in an improved sterilization effect and nearly 100% antibacterial efficiency against S. aureusand E. coli-infected wounds. In vivo experiments not only confirmed the antibacterial properties of the material, but also revealed that the same could fast track wound healing by inhibiting inflammation, promoting angiogenesis as well as collagen deposition, and modulating type-III to type-I collagen ratio [84]. Sherief et al used a similar approach, coating diatomite particles with AgNPs, and showed that the material is effective against five different pathogenic organisms [85].…”

Section: Antibiotics Deliverymentioning

confidence: 91%

“…Finally, Cong et al [84] and Sherief et al [85] have described the antimicrobial activity of metal-coated diatoms. These last two examples do not rigorously fall within the drug delivery category, but are illustrative of the tremendous versatility of diatom biosilica.…”

Section: Antibiotics Deliverymentioning

confidence: 99%

“…These last two examples do not rigorously fall within the drug delivery category, but are illustrative of the tremendous versatility of diatom biosilica. Cong et al described the deposition of copper on Cyclotella cryptica diatoms and the realization of biomaterilas for infected wound therapy [84]. The deposition of copper onto C. cryptica diatoms significantly improved the photothermal and photodynamic performance of material by increasing the yield of ROS under near-infrared light irradiation (Figure 6).…”

Section: Antibiotics Deliverymentioning

confidence: 99%

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Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies

Zobi

2022

Micro

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Diatoms are single-cell algae encased in a cell wall (named frustule) composed of transparent, biogenic (or opaline) silica with intricate and strikingly regular patterns. Over the past 30 years, these microorganisms have proven to be a valuable replacement for synthetic silica that satisfies numerous pharmaceutical requirements for the realization of drug delivery vectors, biosensing supports and photonic crystals. It is not only the structural features of the diatoms, but also the possibility of chemically modifying the frustule that permits the relatively straightforward transformation of the biosilica into potential devices for biomedical applications. In this short review, we explore the applications of diatoms-derived biosilica in the drug delivery and biosensing fields. Specifically, we consider the use of diatoms for the targeted delivery of anticancer and antibiotic drugs and how the same microalgae are employed in the fabrications of biosensors whose analyte signal response is evaluated via fluorescence and surface-enhanced Raman scattering techniques. We limit our discussion to studies published in the last seven years, with the intention of minimizing possible redundancy with respect to previously published contributions.

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Copper‐deposited diatom‐biosilica enhanced osteogenic potential in periodontal ligament stem cells and rat cranium

Feng

Wang

et al. 2023

J Biomed Mater Res

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This study aimed to establish that copper-deposited Diatom-biosilica have the potential and possibility for clinical applications in repairing bone defects in a state of inflammation, such as periodontitis. Treatment of alveolar bone defects caused by periodontitis is a major challenge for clinicians. To achieve better repair results, the material should not only be bone conductive but also have the ability to stimulate osteogenesis and angiogenesis at the lesion site. Copper (II) and silicon (IV) ions could react to form basic copper silicate, which promoted both osteogenesis and angiogenesis. The mineralized diatom (Cu-DBs) loaded with copper (II) ions were synthesized by processing diatom shells using a hydrothermal method. Periodontal ligament stem cells (PDLSCs) are used to detect the osteogenic properties of Cu-DBs at the gene and protein levels. Using a rat cranial defect model and a fullthickness skin incision model to test the osteogenic properties of Cu-DBs in vivo.Compared with untreated diatoms (DBs), Cu-DBs extract significantly promoted the expression of osteogenesis-related factors like ALP, RUNX2, BSP, OCN, and OPN in PDLSCs. In vivo experiments further confirmed that Cu-DBs could effectively stimulate the osteogenesis of a rat skull defect and promote angiogenesis, significantly inhibit the inflammatory responses to bone damages, and reduce the infiltration of inflammatory immune cells to the lesion site. Due to the unique chemical characteristics of Si 4+ and Cu 2+ ions, the Cu-DBs composite biomaterial could enhance the osteogenic differentiation of PDLSCS in vitro, as well as stimulate the osteogenesis of the rat in vivo.

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Copper deposited diatom-biosilica with enhanced photothermal and photodynamic performance for infected wound therapy

Abstract: Considering the increase in drug resistance due to the abuse of antibiotics, non-antibiotic strategies for the treatment of bacterial infections have the necessity and urgency. In this study, copper deposited...

Cited by 9 publications

References 48 publications

Reversible Regulation of the Reactive Oxygen Species Level Using a Semiconductor Heterojunction

Reversible Regulation of the Reactive Oxygen Species Level Using a Semiconductor Heterojunction

Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies

Copper‐deposited diatom‐biosilica enhanced osteogenic potential in periodontal ligament stem cells and rat cranium

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