Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis

Shi, Mengchao; Chen, Zetao; Farnaghi, Saba; Friis, Thor; Mao, Xueli; Xiao, Yin; Wu, Chengtie

doi:10.1016/j.actbio.2015.11.033

Cited by 227 publications

(145 citation statements)

References 48 publications

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“…[[qv: 1a,12]] Regarding the active ions released, studies have verified that magnesium (Mg), strontium (Sr), and copper (Cu) can suppress inflammatory cytokines secreted by macrophages and promote osteogenesis 13. Zinc, an essential trace element constituting some key enzymes and transcription factors, was reported to be indispensable for the development of the immune system, and suitable amounts of zinc can enhance the expression of anti‐inflammatory cytokines and maintain an anti‐inflammatory environment 14.…”

Section: Introductionmentioning

confidence: 99%

Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

et al. 2018

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The cytokines released by immune cells are considered important factors to induce bone tissue regeneration. However, the pathway of those bone‐targeting macrophage cytokines induced by biomaterial surface under tissue microenvironment is rarely reported. In this study, the immunomodulatory capability of zinc ions on macrophage polarization and its effects on osteogenic differentiation are investigated. Hence, a layer of zinc ions are incorporated on sulfonated polyetheretherketone (SPEEK) biomaterials by using a customized magnetron sputtering technique. The results reveal that the microenvironment on Zn‐coated SPEEK can modulate nonactivated macrophage polarization to an anti‐inflammatory phenotype and induce the secretion of anti‐inflammatory and osteogenic cytokines. The osteogenic differentiation capability of bone marrow stromal cells (BMSCs) is therefore enhanced, leading to improved osteointegration between the zinc‐coated SPEEK and bone tissue. This study verifies that zinc ion is a promising additive in the osteoimmunomodulation process and provides knowledge that may pave the way to develop the next generation of immunomodulatory biomaterials.

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Section: Introductionmentioning

confidence: 99%

Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

et al. 2018

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“…92 Additionally, they are easily modifiable in terms of loading other desired particles for delivery to the site of infection and altering the outer charge on the nanoparticles for specifications of the specific tissue being targeted. 14,92–94 Similar to bioactive glass materials, they have also shown to encourage bone regeneration, but more importantly, they are one of a few methods mentioned in this article that actually have shown to promote angiogenesis and pro-inflammatory and macrophage functions within the immune system when combined with copper ions. This was analyzed with the use of alizarin red S and a combination of buffer solutions to track their degradation.…”

Section: Biodegradable Delivery Systemsmentioning

confidence: 98%

The use of nanomaterials to treat bone infections

Snoddy

Jayasuriya

2016

Materials Science and Engineering: C

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A new era of osteomyelitis treatment has been taking strides towards efficient, local administration of antibiotics at the site of infection. By having them localized to the site of infection, this toxicity is no longer an issue and actually has shown to be a more productive treatment for osteomyelitis. Researchers have focused the production of non-biodegradable, antibiotic, infused bone cements specifically designed for proficient osteocyte binding, useful antibiotic release over a desirable period of time, and promotion of bone regeneration. These cements are then surgically placed on the infected site following debridement and irrigation. The problem, however, is that the use of ineffective cements and the overuse of antibiotics has led to the development of resistant bacteria. Due to this, further research is being done in the field of antibiotic discovery and delivery. Specifically, the development of biodegradable materials capable of efficiently delivering antibiotics and also eliminating the need for follow-up surgery to remove the delivery material is being done, thus reducing exposure risk. Nanoparticles have been developed in the forms of scaffolds and injections to deliver a higher degree and longer lasting duration of antibiotic release, while promoting bone regeneration.

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“…Polymers can respond to various external stimulus such as pH, temperature, electromagnetic fields, and mechanical force, for example. 21,22 Recently, Shi et al 23 reported the introduction of hypoxiamimicking bioactive copper ions which have the potential to endow MSNs with both osteogenic and angiogenic capabilities. Due to these characteristics, the stimulusresponsive nanoparticles are described as smart drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Apostolos¹,

Andrade²,

Silva³

et al. 2019

Int J Applied Ceramic Tech

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In this study, we report the production of a mesoporous silica/hydroxyapatite‐based nanocomposite containing copper (Cu) functionalized with methacrylic acid (MAA), a pH‐sensitive polymer. The functionalization of the nanoparticles surface was performed using the microwave method in order to anchor the cross‐linking tetraethylene glycol dimethacrylate (TEGDMA), onto the nanoparticles surface followed by MAA polymerization. The materials were characterized by XRD, XRF spectroscopy, scanning and transmission electron microscopy, Fourier transform infrared spectroscopy, thermal analysis, zeta potential, and elemental analysis. Studies of the incorporation and release of the antitumor methotrexate drug were performed in order to evaluate the potential use of these drug carrier systems in cancer therapy. Moreover, the in vitro cytotoxicity of the samples in fibroblast and SAOS‐2 cells was investigated, and the activity of the adipose‐derived stem cell alkaline phosphatase on nanocomposites was studied by in vitro assays. The results indicate that the Cu‐containing nanocomposites can be easily produced and that these compositions have beneficial effects in stem cells, maintaining cell viability, and allowing alkaline phosphatase expression. In conclusion, data from this work show that the nanocomposites obtained have adequate characteristic to be used as drug delivery platform. Furthermore, the biomaterial is a promising structure for treatment of bone tumor.

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Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis

Cited by 227 publications

References 48 publications

Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

Zinc‐Modified Sulfonated Polyetheretherketone Surface with Immunomodulatory Function for Guiding Cell Fate and Bone Regeneration

The use of nanomaterials to treat bone infections

Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

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