Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria

Díaz-García, Diana; Ardiles, Perla R.; Díaz-Sánchez, Miguel; Mena-Palomo, Irene; Hierro, Isabel del; Prashar, Sanjiv; Rodríguez-Diéguez, Antonio; Páez, Paulina Laura; Gómez‐Ruiz, Santiago

doi:10.1016/j.jinorgbio.2019.110912

Cited by 18 publications

(14 citation statements)

References 75 publications

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“…65 Bacteria, like S. aureus, are very prone to Reactive Oxygen Species (ROS)-induced bactericidal mechanisms. 66 In our case, the high antioxidant activity of KC10 (Fig. 4b, red line) results in ROS inactivation within the bacterial broth, thereby reducing the oxidative stress experienced by the bacterial cells.…”

Section: Bioactive Properties Of the Composite Fiber Matsmentioning

confidence: 59%

“…The peculiar behavior of the KC10 fibers, which show reduced S. aureus inactivation compared to pure essential oil and KC0 (which both show 100% inactivation), could be explained by the efficient radical scavenging of the loaded fibers. It has been previously reported [64][65][66] that a strong antibacterial activity can be related to the presence of free radicals, able to exert a killing oxidative stress onto the bacterial cells. 65 Bacteria, like S. aureus, are very prone to Reactive Oxygen Species (ROS)-induced bactericidal mechanisms.…”

Section: Bioactive Properties Of the Composite Fiber Matsmentioning

confidence: 99%

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Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

et al. 2020

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Section: Bioactive Properties Of the Composite Fiber Matsmentioning

confidence: 59%

Section: Bioactive Properties Of the Composite Fiber Matsmentioning

confidence: 99%

Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

et al. 2020

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“…After 30 minutes of reaction, fluorescence intensity was measured using an enzyme‐labelling instrument (Bio‐Tek SYNERGY2). The optical excitation and emission wavelengths were 488 and 525 nm, respectively 40 …”

Section: Methodsmentioning

confidence: 99%

Preparation of tea tree oil nanoemulsion: Characterisation, antibacterial mechanism and evaluation of apoptosis

Han

Wang

Zhuansun

et al. 2023

Flavour & Fragrance J

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Tea tree oil (TTO) is a natural plant essential oil that has strong bactericidal properties and low toxicity. However, owing to its irritability, volatility, instability under light/oxygen and hydrophobicity, the application of TTO in pharmaceutical production technology and the food industry is limited. To overcome these problems, TTO nanoemulsions (TTONs) were prepared using a high-speed shearing method. The mean droplets size of TTON was measured. TTON droplets were observed using confocal laser scanning microscopy and analysed using a Turbiscan scanning spectrum. The most suitable nanoemulsion formula was obtained as follows: TTO content, 10% (w/w); Tw-40 content, 8% (w/w); deionised water content, 82% (w/w); shearing time, 5 minutes. The antibacterial effect of TTON was studied, and it was found that its antibacterial activity against Escherichia coli was more potent than that against Staphylococcus aureus. The antibacterial mechanism of TTON was also investigated by observing bacterial morphology using scanning electron microscopy and testing the levels of bacterial reactive oxygen species. The effect of TTON on L-02 cells was evaluated. The results showed that the cell survival rates of L-02 cells treated with TTON at 0.05-0.25 μg/μL were all >90%. At each concentration, the total apoptosis rate of L-02 cells was <10%. These results indicated the high biocompatibility and biological safety of TTON. Therefore, the preparation of TTO into a nanoemulsion can improve its bioavailability, which has positive implications for further applications of TTO.

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“…The SBA-15 (Santa Barbara Amorphous material 15) MSS grafted with triethoxysilylpropylmaleamic acid (maleamic) and triethoxy-3-(2-imidazolin-1-yl)propylsilane (imidazoline) was loaded with copper(II) in the presence of 5,5 -dimethyl-2,2 -bipyridine as an ancillary ligand. Although the material with maleamic acid contains a lower amount of Cu(II), it exhibits a higher activity against S. aureus and E. coli strains, properties related to ROS production and with the ability to interfere in both peptidoglycan synthesis and glutathione metabolism [143].…”

Section: Inorganic Based Carriersmentioning

confidence: 99%

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

2020

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Every year, more Cu(II) complexes are proven to be biologically active species, but very few are developed as drugs or entered in clinical trials. This is due to their poor water solubility and lipophilicity, low stability as well as in vivo inactivation. The possibility to improve their pharmacological and/or oral administration profile by incorporation into inorganic or organic matrix was studied. Most of them are either physically encapsulated or conjugated to the matrix via a moiety able to coordinate Cu(II). As a result, a large variety of species were developed as delivery carriers. The organic carriers include liposomes, synthetic or natural polymers or dendrimers, while the inorganic ones are based on carbon nanotubes, hydrotalcite and silica. Some hybrid organic-inorganic materials based on alginate-carbonate, gold-PEG and magnetic mesoporous silica-Schiff base were also developed for this purpose.

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Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria

Cited by 18 publications

References 75 publications

Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

Keratin–cinnamon essential oil biocomposite fibrous patches for skin burn care

Preparation of tea tree oil nanoemulsion: Characterisation, antibacterial mechanism and evaluation of apoptosis

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

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