Copper homeostasis and cuproptosis in cardiovascular disease therapeutics

Yang, Lifang; Yang, Panpan; Lip, Gregory Y. H.; Ren, Jun

doi:10.1016/j.tips.2023.07.004

Cited by 45 publications

(11 citation statements)

References 97 publications

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“… 57 Recent studies have also highlighted the role of Cu homeostasis and cuproptosis, a novel form of regulated cell death, in the development and progression of CVDs. 58 VC is a complex cellular and molecular process, involving the osteochondrogenic transformation of VSMCs, the disturbance of Ca‐phosphate metabolism, inflammation and oxidative stress. 4 Abnormal levels of Cu may cause oxidative stress and inflammatory responses, which may accelerate the progression of VC, but the specific mechanisms are not clear.…”

Section: Discussionmentioning

confidence: 99%

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Mo,

Yin,

Wang

et al. 2024

MedComm

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Vascular calcification is a strong predictor of cardiovascular events. Essential metals play critical roles in maintaining human health. However, the association of essential metal levels with risk of aortic arch calcification (AoAC) remains unclear. We measured the plasma concentrations of nine essential metals in a cross‐sectional population and evaluated their individual and combined effects on AoAC risk using multiple statistical methods. We also explored the mediating role of fasting glucose. In the logistic regression model, higher quartiles of magnesium and copper were associated with the decreased AoAC risk, while higher quartile of manganese was associated with higher AoAC risk. The least absolute shrinkage and selection operator penalized regression analysis identified magnesium, manganese, calcium, cobalt, and copper as key metals associated with AoAC risk. The weighted quantile sum regression suggested a combined effect of metal mixture. A linear and positive dose–response relationship was found between manganese and AoAC in males. Moreover, blood glucose might mediate a proportion of 9.38% of the association between manganese exposure and AoAC risk. In summary, five essential metal levels were associated with AoAC and showed combined effect. Fasting glucose might play a significant role in mediating manganese exposure‐associated AoAC risk.

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Section: Discussionmentioning

confidence: 99%

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Mo,

Yin,

Wang

et al. 2024

MedComm

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“…Copper binds with albumin and ceruloplasmin in the liver and is carried throughout the body via the bloodstream. 80 Copper is vital for maintaining essential cellular functions, as well as involving antioxidant reactions, maintaining cell membrane and DNA integrity, and aiding in ATP production. 81 …”

Section: The Role Of Essential Trace Elementsmentioning

confidence: 99%

The roles of essential trace elements in T cell biology

Lan,

Feng,

Liu

et al. 2024

J Cellular Molecular Medi

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T cells are crucial for adaptive immunity to regulate proper immune response and immune homeostasis. T cell development occurs in the thymus and mainly differentiates into CD4+ and CD8+ T cell subsets. Upon stimulation, naive T cells differentiate into distinct CD4+ helper and CD8+ cytotoxic T cells, which mediate immunity homeostasis and defend against pathogens or tumours. Trace elements are minimal yet essential components of human body that cannot be overlooked, and they participate in enzyme activation, DNA synthesis, antioxidant defence, hormone production, etc. Moreover, trace elements are particularly involved in immune regulations. Here, we have summarized the roles of eight essential trace elements (iron, zinc, selenium, copper, iodine, chromium, molybdenum, cobalt) in T cell development, activation and differentiation, and immune response, which provides significant insights into developing novel approaches to modulate immunoregulation and immunotherapy.

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“…Cuproptosis, a distinctive cell death mechanism, has generated significant interest in cancer research due to its potential in novel therapeutic approaches, including inhibiting tumor cell proliferation and possibly reversing cancer drug resistance, akin to ferroptosis [ 195 – 198 ]. Emerging compounds have shown the ability to induce cuproptosis in preclinical models.…”

Section: Introductionmentioning

confidence: 99%

“…Emerging compounds have shown the ability to induce cuproptosis in preclinical models. Specifically, the downregulation of FDX1, DLAT, SDHB (succinate dehydrogenase complex, subunit B), and DLST (dihydrolipoamide S-succinyltransferase) genes in primary CRC tissues suggests a link to disease progression, with higher expression of these genes correlating to better prognosis [ 195 – 198 ]. ES-Cu treatment notably reduces cell viability in CRC cells.…”

Section: Introductionmentioning

confidence: 99%

Cuproptosis: unveiling a new frontier in cancer biology and therapeutics

Feng,

Yang,

Wang

et al. 2024

Cell Commun Signal

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Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known cell death mechanisms. This process involves the interaction of copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation and cell death. Recently, a growing number of studies have explored the link between cuproptosis and cancer development. This review comprehensively examines the systemic and cellular metabolism of copper, including tumor-related signaling pathways influenced by copper. It delves into the discovery and mechanisms of cuproptosis and its connection to various cancers. Additionally, the review suggests potential cancer treatments using copper ionophores that induce cuproptosis, in combination with small molecule drugs, for precision therapy in specific cancer types.

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Copper homeostasis and cuproptosis in cardiovascular disease therapeutics

Cited by 45 publications

References 97 publications

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

The roles of essential trace elements in T cell biology

Cuproptosis: unveiling a new frontier in cancer biology and therapeutics

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