Copper(II) complexes with 4-hydroxyacetophenone-derived acylhydrazones: Synthesis, characterization, DNA binding and cleavage properties

“…The nicked circular form migrates slowly and the linear form migrates between Form‐I and Form‐II. These three plasmid DNA confirmations are distinguishable when subjected to agarose gel electrophoresis …”

Section: Resultsmentioning

confidence: 99%

“…These three plasmid DNA confirmations are distinguishable when subjected to agarose gel electrophoresis. [38] The pUC18 DNA cleaving activity of L and its metal complexes in the presence of H 2 O 2 as an oxidant was studied using agarose gel electrophoresis ( Fig. 4(a)).…”

Section: Dna Cleavagementioning

confidence: 99%

Transition metal complexes of a novel quinoxaline‐based tridentate ONO donor ligand: synthesis, spectral characterization, thermal, in vitro pharmacological and molecular modeling studies

Dhanaraj

Johnson

2016

Applied Organom Chemis

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Co(II), Ni(II), Cu(II) and Zn(II) complexes of a novel tridentate heterocyclic ligand, 3‐{[(2‐benzoyl‐4‐chlorophenyl)imino]methyl}quinoxalin‐2(1H)‐one, have been synthesized. The ligand and the metal complexes were characterized using elemental analysis, molar conductance and magnetic susceptibility measurements, and UV–visible, Fourier transform infrared, 1H NMR, 13C NMR, electron spin resonance and DART mass spectral data. The ligand behaves as a tridentate one, coordinating through two oxygen atoms from two keto groups and through the azomethine nitrogen atom. The thermal properties of the newly synthesized compounds were determined using thermogravimetric analysis. The ligand and its metal complexes were subjected to powder X‐ray diffraction analysis by which average crystallite size and unit cell parameters were calculated. The electrochemical behaviour of the compounds was studied using cyclic voltammetry. The ligand and the metal complexes were screened for their in vitro antimicrobial activities against the bacterial strains E. coli, K. pneumoniae, S. pneumoniae and S. aureus and the fungal species A. niger, A. flavus, P. chrysogenum and R. stolonifer. DNA binding, DNA cleavage and antioxidant activities of the compounds were also evaluated. The compounds bind with DNA through groove binding. The Cu(II) and Zn(II) complexes exhibit higher superoxide anion and hydrogen peroxide scavenging activities, respectively. The Cu(II) complex exhibits better anticancer activity against the MCF7 cell line. The compounds were subjected to molecular docking study against B‐DNA dodecamer d(CGCGAATTCGCG)2 and vascular endothelial growth factor receptor kinase to justify the experimental DNA binding and MTT assay. Density functional theory studies were used to optimize the geometry of the compounds and to calculate the nonlinear optical properties. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The ligands neutralize the electrical charge of the copper ion and facilitate the transport of the complex through the cell membrane, interacting noncovalently with proteins or intercalating into the DNA molecule [92]. Copper complexes are capable of inducing DNA breaks through hydrolytic or oxidative cleavages [93][94][95][96][97]…”

Section: Coppermentioning

confidence: 99%

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Pedrosa¹,

Carvalho²,

Baptista³

et al. 2018

Basic Concepts Viewed From Frontier in Inorganic Coordination Chemistry

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Metals have unique characteristics such as variable coordination modes, redox activity, and reactivity being indispensable for several biochemical processes in cells. Due to their reactivity, their concentration is tightly regulated inside the cells, and abnormal concentrations are associated with many disorders, such as cancer. As such metal complexes turned out to be very attractive as potential anticancer agents. The discovery of cisplatin was a crucial moment, which prompted the interest in Pt(II) and other metal complexes as potential anticancer agents. This chapter highlights the state of the art on metal complexes in cancer therapy, highlighting their uptake mechanisms, biological targets, toxicity, and drug resistance. Finally, based on the importance of selective target of cancer cells, drug delivery systems will also be discussed.

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Copper(II) complexes with 4-hydroxyacetophenone-derived acylhydrazones: Synthesis, characterization, DNA binding and cleavage properties

Cited by 39 publications

References 36 publications

A copper(II) complex with pyridine-2,6-dicarboxylic acid: Synthesis, characterization, thermal decomposition, bioactivity and interactions with herring sperm DNA

A copper(II) complex with pyridine-2,6-dicarboxylic acid: Synthesis, characterization, thermal decomposition, bioactivity and interactions with herring sperm DNA

Transition metal complexes of a novel quinoxaline‐based tridentate ONO donor ligand: synthesis, spectral characterization, thermal, in vitro pharmacological and molecular modeling studies

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

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