Copper(II) complexes with NNN and NNO Schiff base ligands as efficient photodegradation agents for methylene blue, preferential BSA binder and biomaterial transplants

Jana, Kalyanmoy; Pramanik, U. Datta; Ingle, Kapil S.; Maity, Ribhu; Mukherjee, Saptarshi; Nayak, Susanta K.; Debnath, Subhas Chandra; Maity, Tithi; Maity, Swapan; Samanta, Bidhan Chandra

doi:10.1016/j.jphotochem.2021.113565

Cited by 10 publications

(5 citation statements)

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“…The syntheses, characterization and crystal structure determination of the three complexes along with three heterogeneous Schiff base ligands L1, N-((6-methoxypyridin-2-yl)methylene)-(piperidin-2-yl)methane amine, L2, 2,4-dibromo-6-((3-(methylamino)propylimino)methyl)phenol and L3, 1-((3-(methylamino) propylimino)methyl)naphthalene-2-ol were discussed in our previous publications. 22,23 The crystal structure of complex 1 shows a square pyramidal geometry, whereas the structure of complex 2 shows that the complex consists of penta coordinated double m 1.1 -acetato bridged dinuclear units of Cu(II) and is a centro symmetric dimer in which the centre of inversion lies at the midpoint of two Cu(II) ions (Fig. S7 in the ESI †).…”

Section: Synthesis Characterization and Crystallographic Interpretati...mentioning

confidence: 99%

“…The syntheses of the three complexes were performed using a method reported by Samanta et al 22,23 Characterizations by single crystal X-ray diffraction studies and several other physicochemical techniques such as FT-IR, UV-vis, ESI-MS and NMR to establish the structures of the complexes were also performed by Samanta et al 22,23 (Scheme 1). All the structures of the complexes were established using single crystal X-ray crystallography and these structures are given in Fig.…”

Section: Synthesis Of Complexes and Characterizationmentioning

confidence: 99%

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Unveiling the catecholase activities and DNA binding interaction of mono-, di-, and polymeric Cu(ii) complexes derived from heterogeneous Schiff base ligands

Maity¹,

Maity²,

Jana³

et al. 2023

New J. Chem.

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Section: Synthesis Characterization and Crystallographic Interpretati...mentioning

confidence: 99%

Section: Synthesis Of Complexes and Characterizationmentioning

confidence: 99%

Unveiling the catecholase activities and DNA binding interaction of mono-, di-, and polymeric Cu(ii) complexes derived from heterogeneous Schiff base ligands

Maity¹,

Maity²,

Jana³

et al. 2023

New J. Chem.

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“…Other common side effects include anaphylaxis, cytopenias, etc . So, very recently, developing active anticancer agents based on other transition metal complexes with new mechanisms of action and better efficacy attracts the attention of chemists and biologists. − …”

Section: Introductionmentioning

confidence: 99%

Small Molecule Interactions with Biomacromolecules: DNA Binding Interactions of a Manganese(III) Schiff Base Complex with Potential Anticancer Activities

Khatun,

Modak,

Islam

et al. 2023

ACS Appl. Bio Mater.

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((E)-(2-((E)-2-hydroxy-3-methoxybenzylidene-amino)-ethylimino)methyl)-6-methoxyphenol), has been synthesized and characterized by single-crystal X-ray diffraction analysis. The interaction of 1•H 2 O with DNA was studied by monitoring the decrease in absorbance of the complex at λ = 324 nm with the increase in DNA concentration, providing an opportunity to determine the binding constant of the 1•H 2 O−ct-DNA complex as 5.63 × 10 3 M −1 . Similarly, fluorescence titration was carried out by adding ct-DNA gradually and monitoring the increase in emission intensity at 453 nm on excitation at λ ex = 324 nm. A linear form of the Benesi−Hildebrand equation yields a binding constant of 4.40 × 10 3 M −1 at 25 °C, establishing the self-consistency of our results obtained from absorption and fluorescence titrations. The competitive displacement reactions of dyes like ethidium bromide, Hoechst, and DAPI (4′,6-diamidine-2′-phenylindole dihydrochloride) from dye−ct-DNA conjugates by 1•H 2 O were analyzed, and the corresponding K SV values are 1.05 × 10 4 , 1.25 × 10 4 , and 1.35 × 10 4 M −1 and the K app values are 2.16 × 10 3 , 8.34 × 10 3 , and 9.0 × 10 3 M −1 , from which it is difficult to infer the preference of groove binding over intercalation by these DNA trackers. However, the molecular docking experiments and viscosity measurement clearly indicate the preference for minor groove binding over intercalation, involving a change in Gibbs free energy of −8.56 kcal/mol. The 1•H 2 O complex was then evaluated for its anticancer potential in breast cancer MCF-7 cells, which severely abrogates the growth of the cells in both 2D and 3D mammospheres, indicating its promising application as an anticancer drug through a minor groove binding interaction with ct-DNA.

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“…Notably, complexes of transition metals hold particular allure owing to their adaptability in geometric arrangements, a variety of coordination numbers, and a range of oxidation states. Among these transition metals, copper emerges as a noteworthy contender for its demonstrated potential to engage with diverse Schiff base ligands in bio property investigations [13–16] . This stems from copper‘s successful application in various redox systems and its pivotal role in several crucial enzyme activity processes.…”

Section: Introductionmentioning

confidence: 99%

“…Among these transition metals, copper emerges as a noteworthy contender for its demonstrated potential to engage with diverse Schiff base ligands in bio property investigations. [13][14][15][16] This stems from copper's successful application in various redox systems and its pivotal role in several crucial enzyme activity processes. It is worth highlighting that high-valent copper complexes often assume a pivotal role as intermediates in chemical reactions germane to both biological and synthetic catalysis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, XRD/HSA‐Interactions, QTAIM Analysis, Optical and Nonlinear Optical Responses Studies of Cu(II) Complex with the Schiff Base Ligand Derived from 5‐Bromosalicylaldehyde

Lamiri,

Djaafer‐Moussa,

Merabet

et al. 2023

ChemistrySelect

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In this study, we efficiently synthesized a new Schiff base ligand (H2L) along with its mononuclear complex Cu(II) (1). The chemical structures of these compounds were rigorously determined using various analytical techniques, including UV‐ Vis., FT‐IR, 1H NMR, 13 C NMR CHN elemental analysis, single crystal X‐ray diffraction, and quantum calculations. The X‐ray diffraction analysis of the complex revealed the presence of intermolecular interactions characterized by C−H…Br hydrogen bonds, leading to the formation of 2D layers. We conducted a systematic investigation of these intermolecular interactions using HS and QTAIM analysis. Additionally, we affected a comprehensive analysis of H2L, 1, and 2, focusing on their structural, electronic, and optical properties using DFT and TD‐DFT calculations in gas and solvent. The computed parameters closely matched the experimental data, demonstrating good agreement. Reactivity parameters indicated that complex 2 exhibited lower hardness (~1.7 eV) compared to 1 (~1.8 eV) and H2L (~4.4 eV). NLO analysis revealed substantial α and β values for compound 2 in both static and dynamic regimes. Notably, the β values of the title complexes increased with higher solvent polarity. In summary, our investigation highlights the potential of the title complexes as promising candidates for second‐order nonlinear optical materials.

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Copper(II) complexes with NNN and NNO Schiff base ligands as efficient photodegradation agents for methylene blue, preferential BSA binder and biomaterial transplants

Cited by 10 publications

References 70 publications

Unveiling the catecholase activities and DNA binding interaction of mono-, di-, and polymeric Cu(ii) complexes derived from heterogeneous Schiff base ligands

Unveiling the catecholase activities and DNA binding interaction of mono-, di-, and polymeric Cu(ii) complexes derived from heterogeneous Schiff base ligands

Small Molecule Interactions with Biomacromolecules: DNA Binding Interactions of a Manganese(III) Schiff Base Complex with Potential Anticancer Activities

Synthesis, XRD/HSA‐Interactions, QTAIM Analysis, Optical and Nonlinear Optical Responses Studies of Cu(II) Complex with the Schiff Base Ligand Derived from 5‐Bromosalicylaldehyde

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