Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure–activity relationship

Efthimiadou, Eleni K.; Katsarou, Maria E.; Karaliota, Alexandra; Psomas, George

doi:10.1016/j.jinorgbio.2007.12.011

Cited by 116 publications

(61 citation statements)

References 51 publications

(102 reference statements)

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“…Therefore, in recent years there has been a rapid expansion in research and development of novel metalbased biologically active and anticancer complexes [2][3][4]. Numerous mixed ligands transition metal complexes have been investigated by various techniques and their biological activities were extensively studied [5][6][7][8][9][10]. Chelating ligands containing O, S and N donor atoms show broad biological activity and are of special interest because of the variety of ways in which they are onded to metal ions [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

Islam¹,

Magda²

2017

Mod Chem Appl

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Four series of novel mixed ligand-drug complexes of thiamine hydrochloride as a primary ligand and four azo compounds, as secondary ligands, were prepared using Co (II), Ni (II), Cu (II) and Zr (IV) ions. The complexes were characterized by elemental analysis, thermogravimetric analysis, molar conductivity, FT-IR, magnetic susceptibility and UV-Visible spectroscopy. Based on the analytical and spectral data, the complexes were formulated as [Azo -M -Thiamine (H 2 O) n ] + Cl -where n=2 for Co (II), Ni (II) and Cu (II) and=1 for Zr (IV). All the complexes possessed octahedral geometry in which both the primary and secondary ligands act as monovalent monodentate coordinated via ON fashion in case of azo compounds and via OS fashion in case of thiamine hydrochloride. Biological activity of some complexes has been evaluated against a number of pathogenic bacteria and fungi. Obtained results indicated that the metal complexes exhibited better antimicrobial and antifungal activities.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

Islam¹,

Magda²

2017

Mod Chem Appl

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“…All the metal complexes exhibits higher inhibition against all microorganisms tested except S. aureus K1 compared to free enrofloxacin. The biological activity of many fluoroquinolone increased after the coordination with metal 12,14,22,31 and the rate of antimicrobial activity of the metal complexes depending on the following five principal factors, 42−45 (i) the chelate effect, (ii) the nature of coordinated ligands, (iii) the total charge of the complex, (iv) the nature of the ion neutralizing the ionic complex, (v) the nuclearity of the metal center in the complex. According to the overtone concept of all permeability, the lipid membrane that surrounds the cell favors the passage of only lipid soluble materials in which liposolubility is an important factor that controls the antimicrobial activity.…”

Section: Biological Activities Testmentioning

confidence: 99%

Metal Complexes of Enrofloxacin Part I: Preparation, Spectroscopic, Thermal Analyses Studies and Antimicrobial Evaluation

El‐Shwiniy¹,

El‐Attar²,

Sadeek³

2013

Journal of the Korean Chemical Society

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ABSTRACT. The interaction of titanium (IV), yttrium (III), zirconium (IV), palladium (II) and cerium (IV) with deprotonated enrofloxacin leads to the formation of the neutral or cationic mononuclear complexes. The isolated solid complexes have been characterized with physicochemical and spectroscopic techniques and thermogravimeteric analyses. The spectroscopic data indicate that the enrofloxacin ligand is on the deprotonated mode acting as bidentate ligand coordinated to the metal ions through the ketone oxygen and a carboxylato oxygen and the metal ions completed the coordination number with water molecules. The thermal decomposition mechanisms proposed for enrofloxacin and their metal complexes were discussed. The activation energies, E * , enthalpies, ∆H * , entropies, ∆S * and Gibbs free energies, ∆G * , of the thermal decomposition reactions have been derived from thermogravimetric (TG) and differential thermogravimetric (DTG) curves, using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods. The antimicrobial activity has been evaluated against six different microorganisms.

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“…13 Recently, numerous research groups have reported novel copper(II) complexes with organic ligands showing antifungal and antibacterial properties against several pathogenic fungi and bacteria. [14][15][16] Nickel is also an essential element involved in the life process can promote the absorption of iron element, the increase of red corpuscle and the synthesis of some amino-enzymes in body and its coordination compounds display interesting binding and cleavage reactivity with nucleic acids. 17,18 Nickel complexes have also drawn much attention due to their environmental toxicity, carcinogenic nature and chemotherapeutic property in the past years.…”

Section: 5mentioning

confidence: 99%

Template Synthesis of Polyaza Macrocyclic Copper(II) and Nickel(II) Complexes: Spectral Characterization and Antimicrobial Studies

Gurumoorthy¹,

Ravichandran²,

Karthikeyan³

et al. 2012

Bulletin of the Korean Chemical Society

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The template synthesis of copper(II) and nickel(II) complexes derived from 2,6-diformyl-4-methylphenol with diethylenetriamine or 1,2-bis(3-aminopropylamino)ethane produce the 12-membered N 3 O and 17-membered N 4 O macrocyclic complexes, respectively. The geometry of the complexes has been determined with the help of electronic and EPR spectroscopic values and found to be five coordinated square pyramidal and, six coordinated distorted tetragonal for 12-membered and 17-membered macrocyclic complexes, respectively. Electrochemical studies of the mononuclear N 3 O and N 4 O copper(II) complexes show one irreversible oneelectron reduction wave at E pc = -1.35 and -1.15 V respectively, and the corresponding nickel(II) complexes show irreversible one-electron reduction wave at E pc = -1.25 and -1.22 V, respectively. The nickel(II) complexes show irreversible one-electron oxidation wave at E pa = +0.84 and +0.82 V, respectively. All the complexes were evaluated for in vitro antimicrobial activity against the human pathogenic bacteria and fungi.

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Copper(II) complexes with sparfloxacin and nitrogen-donor heterocyclic ligands: Structure–activity relationship

Cited by 116 publications

References 51 publications

Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

Metal Complexes of Enrofloxacin Part I: Preparation, Spectroscopic, Thermal Analyses Studies and Antimicrobial Evaluation

Template Synthesis of Polyaza Macrocyclic Copper(II) and Nickel(II) Complexes: Spectral Characterization and Antimicrobial Studies

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