Copper nano-architecture topical cream for the accelerated recovery of burnt skin

Abstract

Skin burns are debilitating injuries with significant morbidity and mortality associated to infections and sepsis, especially in immunocompromised patients. In this context, nanotechnology can provide pioneering approaches for the topical...

Drug-Free Hybrid Nanoarchitecture Modulation of the Metastatic Behavior of Pancreatic Ductal Adenocarcinoma in Alternative in Vivo Models

“…The similar morphological features of AuNAs and CuNAs allow to correlate the biological effects to the chemical nature of the inner metal. 33 The in vitro studies were performed on the BxPC-3 human pancreatic cancer cell line. The BxPC-3 cell line is among the most invasive PDAC cell line, bearing mutations on TP53, SMAD4, and CDKN2A, whereas KRAS is in its wild-type sequence.…”

“…At 24 h post-incubation, the small leakage of copper from the whole NAs stimulated cell viability. 33 After the biodegradation of the silica shell, the burst release of copper overcame the buffering capacity of cells. 47 With non-excessive damage, the efflux systems may have promoted the excretion of the exceeding ions to restore the homeostatic intracellular copper concentration.…”

“…The polymeric templates enclosing USMNPs are embedded in a silica capsule formed via a modified Stober reaction (final diameter: ∼150 nm). 14,33 The silica shell protects the inner core and provides a modifiable surface for active targeting purposes. 38 The synthetic protocol is standardized with a high batch-by-batch homogeneity, and its versatility is demonstrated by the possibility to include various metals (gold, silver, platinum, copper) and/or active molecules or dyes.…”

“…On the other hand, rationally designed copper nanomaterials, such as copper nanoarchitectures (CuNAs), can be employed at therapeutic dosages to promote wound healing without inducing significant toxicity nor altering the systemic metabolism of copper. 33 Here, we demonstrate that AuNAs modulate the metastatic behavior of PDAC in alternative in vivo models at non-toxic metal concentrations. We compared the findings with CuNAs to evaluate the dependence of the effects on the chemistry of the metal.…”

“…Indeed, it should be noted that copper ions released from CuNPs may interact with cysteine and methionine residues in proteins, potentially affecting their biological safety. On the other hand, rationally designed copper nanomaterials, such as copper nanoarchitectures (CuNAs), can be employed at therapeutic dosages to promote wound healing without inducing significant toxicity nor altering the systemic metabolism of copper …”