Copper-nanoparticle-embedded hydrogel for killing bacteria and promoting wound healing with photothermal therapy

Tao, Bailong; Lin, Changjian; Deng, Yiman; Yuan, Zhangfu; Shen, Xinkun; Chen, Maowen; He, Ye; Peng, Zhihong; Hu, Yan; Cai, Kaiyong

doi:10.1039/c8tb03272f

Cited by 229 publications

(191 citation statements)

References 57 publications

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“…Complete antibacterial efficiency was rarely fulfilled under solo laser irradiation. Therefore, compared with other nanoparticles using solo PTA or PDA, [41, 42] the dual-mode phototherapy antibacterial treatment of NGO-BSA-AIE NPs achieved high antibacterial effect while avoiding the high temperature associated with continuous photothermal therapy that could damage the surrounding normal tissues and cells, as well as the side effects of continuous photodynamic therapy. In addition, the efficient inhibition of NGO-BSA-AIE NPs against antibiotic-resistant bacteria has a great potential to overcome multi-drug resistance in bacteria by comparison with other reported antibacterial particles [43, 44].…”

Section: Resultsmentioning

confidence: 99%

Construction of biocompatible bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen for dual-mode phototherapy bacteriostatic and bacterial tracking

Zhang

Liu

et al. 2019

J Nanobiotechnol

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Background Efficient and highly controllable antibacterial effect, as well as good biocompatibility are required for antibacterial materials to overcome multi-drug resistance in bacteria. Herein, nano graphene oxide (NGO)-based near-infrared (NIR) photothermal antibacterial materials was schemed to complex with biocompatible bovine serum albumin (BSA) and aggregation-induced emission fluorogen (AIEgen) with daylight-stimulated ROS-producing property for dual-mode phototherapy in the treatment of antibiotic resistance bacteria. Results Upon co-irradiation of daylight and NIR laser, NGO-BSA-AIE nanoparticles (NPs) showed superiorly antibacterial effect (more than 99%) both against amoxicillin (AMO)-resistant Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by comparison with sing-model phototherapy. Meanwhile, the NGO-BSA-AIE NPs displayed prominent stability and excellently controllable biocompatibility. More importantly, under daylight irradiation, the AIEgen not only produced plentiful ROS for killing bacteria, but also presented fluorescence image for tracking bacteria. Conclusions Hence, the designed system provided tempting strategy of employing light as impetus for tracking bacterial distribution and photothermal/photodynamic synergistic treatment of antibiotic resistance antibacterial.

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Section: Resultsmentioning

confidence: 99%

Construction of biocompatible bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen for dual-mode phototherapy bacteriostatic and bacterial tracking

Zhang

Liu

et al. 2019

J Nanobiotechnol

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“…Because silver is widely used in topical antimicrobial products, its use in nanoparticle form has received substantial attention, demonstrating antimicrobial activity [109,115,181]. Other metallic nanoparticles such as gold, zinc, and copper also show good antimicrobial properties [110,136,207]. However, several metal nanoparticles, including silver, copper oxide, and zinc oxide, have exhibited toxic effects in the body [25].…”

Section: Nanoscale Materialsmentioning

confidence: 99%

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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“…[ 79 , 80 , 81 , 82 , 83 ]. Inorganic nanomaterials such as metals [ 84 ], transition metals [ 85 ], and carbon-based nanomaterials [ 86 ] with a photothermal effect can be incorporated into hydrogels to improve the photothermal capacities. Although inorganic nanomaterials are better photothermal agents, organic nanomaterials also exhibit the same properties.…”

Section: Polymer-based Nanomaterialsmentioning

confidence: 99%

Nanomaterials for the Photothermal Killing of Bacteria

et al. 2020

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An upsurge in the multidrug-resistant (MDR) bacterial pestilence is a global cause for concern in terms of human health. Lately, nanomaterials with photothermal effects have assisted in the efficient killing of MDR bacteria, attributable to their uncommon plasmonic, photocatalytic, and structural properties. Examinations of substantial amounts of photothermally enabled nanomaterials have shown bactericidal effects in an optimized time under near-infrared (NIR) light irradiation. In this review, we have compiled recent advances in photothermally enabled nanomaterials for antibacterial activities and their mechanisms. Photothermally enabled nanomaterials are classified into three groups, including metal-, carbon-, and polymer-based nanomaterials. Based on substantial accomplishments with photothermally enabled nanomaterials, we have inferred current trends and their prospective clinical applications.

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Copper-nanoparticle-embedded hydrogel for killing bacteria and promoting wound healing with photothermal therapy

Abstract: Cu-NP-embedded hydrogel (BACA/Cu NPs/Gel-MA hydrogel) produces ROS for photothermal therapy, killing bacteria, and promoting wound healing.

Cited by 229 publications

References 57 publications

Construction of biocompatible bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen for dual-mode phototherapy bacteriostatic and bacterial tracking

Construction of biocompatible bovine serum albumin nanoparticles composed of nano graphene oxide and AIEgen for dual-mode phototherapy bacteriostatic and bacterial tracking

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

Nanomaterials for the Photothermal Killing of Bacteria

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