Copper-olsalazine metal-organic frameworks as a nanocatalyst and epigenetic modulator for efficient inhibition of colorectal cancer growth and metastasis

Li, Junhua; Li, Jing; Cun, Ju-E; Pan, Qingqing; Gao, Wenxia; Luo, Kui; Zhang, Zhuangzhuang; Gu, Zhongwei; Pu, Yuji

doi:10.1016/j.actbio.2022.08.076

Cited by 35 publications

(29 citation statements)

References 74 publications

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“…In addition to Fenton/Fenton-like reactions, some nanoscale metal-based nanocatalysts (also known as nanozymes) with peroxidases (POD)-like activity, such as metal oxides (CeO 2 , 109,110 V 2 O 5 , 111 and Co 3 O 4 112 ) and metal–organic frameworks (MOFs) (MOF/Co, MOF/Au and MOF/Ce, etc .) 113–116 can also catalyze the generation of highly cytotoxic ˙OH from H 2 O 2 . Throughout this process, the nanoparticle acts as a mediator of electron transfer and facilitates the reaction between H 2 O 2 and the substrate.…”

Section: Design Of Ros Generation and Upregulation Systemsmentioning

confidence: 99%

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

et al. 2023

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Section: Design Of Ros Generation and Upregulation Systemsmentioning

confidence: 99%

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

et al. 2023

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“…For example, β -Cyclodextrin conjugated polyethyleneimine (PEI-CD) was used as a carrier to deliver indomethacin to the colon, acting as gastro-off /intestinal-on formulas [78]. Also, unique colon delivery methods have been developed for treating inflammatory bowel diseases using Sulfasalazine, ipsalazide, and olsalazine [79][80][81][82][83][84][85][86].…”

Section: Nanovectors For Controlled Drug Releasementioning

confidence: 99%

Controlled and Targeted Drug Delivery Using Smart Nanovectors

Salama

Salem

Mohamed³

2023

IJDDP

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Review Controlled and Targeted Drug Delivery Using Smart Nanovectors Abou Bakr M. Salama 1,2, Yasmin Y. Salem 1,2, and Tamer M. A. Mohamed 1,3,4,5,6, * 1 Institute of Molecular Cardiology, Department of Medicine, University of Louisville, KY 40208, U.S.A. 2 Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt. 3 Envirome Institute, Centre for Cardiometabolic Sciences, Department of Medicine, University of Louisville, KY 40208, U.S.A. 4 Department of Bioengineering, Speed School of Engineering, University of Louisville, KY 40208, U.S.A. 5 Department of Pharmacology and Toxicology, University of Louisville, KY 40208, U.S.A. 6 Institute of Cardiovascular Sciences, University of Manchester M13 9PL, U.K. * Correspondence: tamer.mohamed@louisville.edu Received: 28 January 2023 Accepted: 23 February 2023 Published: 20 March 2023 Abstract: The conventional drug delivery systems have several limitations, such as the high frequency of administration, several off-target effects, and the need for tissue specificity. Recently, smart drug shuttles have emerged, and the nano applications provided a new opportunity for advancing the drug delivery system to become tissue targeted and decrease the frequency of administration. The recent development of nanovectors as drug carriers has gone through several steps of evolution that ended with the development of logic-embedded nanovectors. Here, we summarize the different types of nanovectors and their applications in various clinical situations, and finally, we spot the light on the future of this area of research.

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“…Copper-based MOFs have excellent physicochemical properties among MOFs and have recently attracted wide attention in various biomedical applications [28]. Some nanoMOFs based on Cu 2+ , exert antiproliferative effect by transforming H 2 O 2 , an important compound in reactive oxygen species family that has higher concentrations in tumor tissues than in normal tissues, into highly cytotoxic •OH through Fenton/Fenton-like reactions or catalytic effect [29]. Considering the pharmacological properties of flavonoids and the metal-assisted cancer therapy of copper, we focus on synthesizing some carboxyl-containing flavonoids and their complexes to explore their potential applications as new chemotherapeutic agents.…”

Section: Structural Descriptionmentioning

confidence: 99%

The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

et al. 2022

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A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu2(L)2·2NMP}n (H2L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration.

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Copper-olsalazine metal-organic frameworks as a nanocatalyst and epigenetic modulator for efficient inhibition of colorectal cancer growth and metastasis

Cited by 35 publications

References 74 publications

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Controlled and Targeted Drug Delivery Using Smart Nanovectors

The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

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