Copper–Psychoactive Drug Complexes: A Voltammetric Approach to Complexation by 1,4-Benzodiazepines

Square-wave voltammetric techniques for determination of psychoactive 1,4-benzodiazepine drugs

“…Direct square-wave voltammetry For all the benzodiazepines used, and as shown elsewhere [39], reduction of the azomethine group is an irreversible process. Because loss of sensitivity might occur in SWV for non-reversible processes [37], direct reduction of the benzodiazepines under study was carefully analysed over a range of square wave conditions.…”

An Overview on Total Analytical Methods for the Detection of 1,4-Benzodiazepines

“…The voltammetric behavior was then interpreted in terms of complex formation. Copper complexation by the 1,4-benzodiazepines was investigated using Cyclic Voltammetry (CV) at a mercury electrode in 0.10M KNO 3 and pH 7.0-0.1 [136]. Direct square-wave voltammetry (SWV) and square-wave cathodic stripping voltammetry (SWCSV) at hanging mercury drop electrodes have been developed for determination of the psychoactive 1,4-benzodiazepines; clonazepam, bromazepam, midazolam, diazepam, medazepam, and flurazepam [137].…”

Copper and Anesthesia: Clinical Relevance and Management of Copper Related Disorders

“…Copper-Lorazepam complexes are biologically active, have a rapid onset, and duration more prolonged than Lorazepam itself [80]. Intracerebral injections of copper sulfate have been shown to potentiate morphine analgesia in rats.…”