Copper(i) and silver(i) complexes of anthraldehyde thiosemicarbazone: synthesis, structure elucidation, in vitro anti-tuberculosis/cytotoxic activity and interactions with DNA/HSA

Abstract

Reaction of copper (I) halides (X = I, Br, Cl) and silver (I) halides with 9-anthraldehyde thiosemicarbazone (9-Hanttsc, H1L) and triphenylphosphine formed halogen-bridged dinuclear complexes, [M2(2-X)2(1-S-9-Hanttsc)2(Ph3P)2] (M = Cu, X...

Evaluating Coordinative Binding Mechanisms through Experimental and Computational Studies of Methoxy‐Substituted Arylazothioformamide Copper(I) Complexes

“…Coordination complexes from [(CH 3 CN) 4 Cu I ](BF 4 ), (13,16,19), produced expected 2 : 1 species with analogous bond distances and angles. Complex (16), from ortho-MeOATF (8), gave two similar but unique complexes in the unit cell (only one shown in Figure 4).…”

“…To note is the extended C 1 = S 1 bond distance in (11) of 1.712 Å over (2 a) of 1.684 Å, which is rationalized as each sulfur atom in the dimer being coordinated to both Cu atoms in this exo-Br structure vs. one Cu atom (as in (μ-Br)-2 a). Exo-Br structures like (11) have precedent with anti-tuberculosis Ag(I) and Cu(I) thiosemicarbazone complexes, [16,17] yet are novel for the ATF ligand class. Additionally, a single water molecule was found in the crystal structure for (11), but with minimal short contacts, suggesting either slightly wet THF or possibly hydrated Cu I Br salt.…”

“…Continuing, crystallization studies of Cu I salts with ortho-MeOATF and meta-MeOATF gave structures (14)(15)(16)(17)(18)(19) as shown in Figure 4 (Full X-ray data is available for these complexes in ESI, Tables S2 and S3) with bond distances noted in Table 1. Complex (14), which proved difficult to crystallize, produced a most unique 1 : 1 dimer complex with only one sulfur atom of the dimer coordinating with both Cu atoms at distances of 2.365 and 2.422 Å allowing for a CuÀ Cu distance of 2.770 Å.…”

Silver Complexes as Anticancer Agents: A Perspective Review

“…Ag-glycine and nicotinamide based complexes [Ag(HGly)2]2(NO3)2n and [Ag(Nam)2]NO3.H2O were designed and evaluated the anticancer activity in the L1210 cancer cell line, which resulted in cell death through the plasma membrane blebbing, nuclear condensation and shrinking of cells. The silver-glycine and nicotinamide complexes showed topoisomerase I and II inhibition [51,52]. The amphiphilic cation porphyrin-Ag (II) complex 47 was prepared as an antiproliferative agent.…”

Bis{N′-[3-(4-nitrophenyl)-1-phenylprop-2-en-1-ylidene]-N-phenylcarbamimidothioato}zinc(II): crystal structure, Hirshfeld surface analysis and computational study

“…The enhanced activities may be attributed to the redox potential and increased lipophilicity of the metal complexes (Rapheal et al, 2021). Transition-metal complexes derived from thiosemicarbazones exhibit widespread pharmacological activities inclusive of anti-tubercular (Khan et al, 2020), antimicrobial (Nibila et al, 2021), anti-bacterial (Prajapati & Patel, 2019), anti-malarial (Savir et al, 2020), anti-diabetic (Kumar et al, 2020), anti-viral (Rogolino et al, 2015) and anti- ISSN 2056-9890 cancer (Anjum et al, 2019;Balakrishnan et al, 2019). In this work, 4-phenyl-3-thiosemicarbazide was condensed with 4-nitrochalcone to form the thiosemicarbazone, which was then complexed with zinc(II) in a molar ratio of 2:1 to form the title compound, hereafter (I).…”