Copper solid amalgam electrode as a simple and sensitive tool for voltammetric determination of the antineoplastic drug 5-fluorouracil in pharmaceuticals

Šelešovská, Renáta; Janíková, Lenka; Štěpánková, Michaela; Chýlková, Jaromíra

doi:10.1007/s11696-016-0091-6

Cited by 2 publications

(3 citation statements)

References 59 publications

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“…64 Other successful electrode modification strategies involve the use of nanoparticles, 61,66 ionic liquids, 63 graphene oxide and carbon-nanotubes, 71 methylene blue (MTB), 67 and the use of copper electrodes. 77 Important to point out is the work by Hadi et al in 2017, utilizing a combination of graphene oxide and carbon nanotubes to modify GCEs and SPCEs. This method shows the widest analytical dynamic linear range from 0.05 to 1200 × 10 −6 M, which is shown useful for the determination of 5-FU in human plasma.…”

Section: Literature Reviewmentioning

confidence: 99%

Review—Electrochemical Approaches and Advances towards the Detection of Drug Resistance

Islam

Luu

Kuss

2020

J. Electrochem. Soc.

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Drug resistance in bacteria and cancer is a growing problem that decreases drug treatment effectiveness and increases the severity of bacterial infections as well as cancer mortality. Due to their high sensitivity, low cost, and rapid analysis time, electrochemical methods have been increasingly employed to tackle this challenge throughout the last decade. This review covers literature on the electrochemical characterization of antibiotics and chemotherapeutic drugs, as well as advances in analyzing interactions between drug compounds and biological cells. Recent developments towards the quantitative detection of drug resistance in bacteria and cancer by electrochemistry are discussed, and the use of specialized electrochemical instrumentation, such as scanning electrochemical microscopy, is highlighted.

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Section: Literature Reviewmentioning

confidence: 99%

Review—Electrochemical Approaches and Advances towards the Detection of Drug Resistance

Islam

Luu

Kuss

2020

J. Electrochem. Soc.

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“…These electrodes are solid, small and have lower mercury content and at the same time, many properties of the mercury drop electrode have been retained. Various types of metals with varying percentages are used to make these electrodes [26–29] . The most common type of these electrodes is obtained by mixing various powdered metals such as gold, silver, copper, and platinum with mercury [30,31] .…”

Section: Introductionmentioning

confidence: 99%

“…The ability of copper to form complex with organic compounds has made it an iteristing option to make amalgam electrodes. Determination of thiram pesticide [36] and 5‐fluorouracil in pharmaceuticals [27] were inspired by this property of copper. Combining cathodic stripping voltammetry and hanging copper amalgam drop electrode has been reported to be also a very effective way to measure some metal ionssuch as arsenic [37] and selenium [38,39] .…”

Section: Introductionmentioning

confidence: 99%

Preparation of a New Copper/Mercury‐Based Amalgam Electrode with Minimal Mercury Content and Its Application for the Determination of Azathioprine in Biological Fluids

2021

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Herein, a new copper/mercury‐based amalgam electrode with 45 wt % copper was introduced. An amalgam electrode with the lowest mercury content among all amalgam electrodes, reported so far,was introduced. The method of making and activating the electrode was investigated and the working conditions were established. The as‐prepared electrode was employed to determine azathioprine(Aza) using differential pulse adsorptive stripping voltammetry (DPASV) method. The required factors were considered for the electrode voltammetric response to evaluate and optimize Aza level. The proper response of this electrode was obtained in Brinton‐Robinson buffer(BRB) (pH 2) at −0.15 V for 200 seconds. The electrode response to the target compound was linear in the concentration range from 0.04 to 1.0 μM. The detection limit was found to be about 1.6×10−8 M. The relative standard deviation (RSD) for 5 determinations was obtained to be about 3.5 % (the average of RSDs calculated for all concentrations, represented in the calibration curve). The method was successfully applied for Aza determination in plasma and urine samples which led to satisfactory results. It can be concluded that the presence of high levels of potential interfering agents such as ascorbic acid and cysteine did not affect the Aza determination.

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Copper solid amalgam electrode as a simple and sensitive tool for voltammetric determination of the antineoplastic drug 5-fluorouracil in pharmaceuticals

Cited by 2 publications

References 59 publications

Review—Electrochemical Approaches and Advances towards the Detection of Drug Resistance

Review—Electrochemical Approaches and Advances towards the Detection of Drug Resistance

Preparation of a New Copper/Mercury‐Based Amalgam Electrode with Minimal Mercury Content and Its Application for the Determination of Azathioprine in Biological Fluids

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