Coprecipitation of Cefuroxime Axetil–PVP composite microparticles by batch supercritical antisolvent process

Uzun, İpar Nimet; Sipahigil, Oya; Dinçer, Salih

doi:10.1016/j.supflu.2010.09.035

Cited by 51 publications

(34 citation statements)

References 74 publications

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“…Indeed, some authors attempted SAS polymer/drug coprecipitation; but, the obtained particles were generally irregular [37] or coalescing [38,39], with broad particle size distributions [40,41], low drug loadings [12,42] and, in most cases, the demonstration of the effective coprecipitation was at least questionable [43][44][45][46]. In general, the authors had difficulties in demonstrating that a coprecipitate was formed and that drug properties were improved.…”

Section: Introductionmentioning

confidence: 99%

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Prosapio

Marco

Scognamiglio

et al. 2015

Chemical Engineering Journal

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Section: Introductionmentioning

confidence: 99%

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Prosapio

Marco

Scognamiglio

et al. 2015

Chemical Engineering Journal

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“…Due to the fact that the yield is calculated by the weight difference between the calcined and the total amount of polymer introduced there must be a minimum quantity of polymer, as Wang et al indicated [28], to encapsulate the particle. This parameter cannot be optimize because it depends on the requirement of the product.…”

Section: Mass Ratio Polymer-particlementioning

confidence: 99%

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Martín

Romero-Díez

Rodríguez‐Rojo

et al. 2015

Chemical Engineering Journal

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A process to coat nanoparticle agglomerates has been developed and its critical operation parameters have been studied in this work. It consists on a fluidized bed where a supercritical anti-solvent process (SAS) takes place. Titanium dioxide (TiO2), used as model nanoparticle, has been coated with a polymer, Pluronic F-127, from an ethanolic solution. As main factors that can affect the coating process, the following process parameters were studied: the ratio between the velocity of carbon dioxide through the bed and the minimum fluidization velocity (umf), with values from 1.5 to 2.5 times the umf; the density of carbon dioxide, varying from 640 kg/m 3 to 735 kg/m 3 approximately; the flow rate of solution, within an interval between 0.5-2 mL/min; the concentration of the solution, from 0.030 mg/mL to 0.090 mg/mL and the mass ratio polymer-particle, 0.45-1.8 g/g. The process parameters were selected taking into account the values that increased the yield, defined as gram of coating material per gram of introduced polymer amount, and maintained a unimodal particle size distribution (PSD), with low increment in the mean particle size with respect to raw TiO2. All the samples were analyzed by four different methods, which showed the successful results of the experiments. The yield was analyzed gravimetrically, and the PSD was determined by laser diffraction. The presence of polymer on the surface of the nanoparticle agglomerates was verified by FT-IR spectrum and fluorescence microscopy, which also showed the quality and uniformity of the coating. Furthermore, the bulk density of the samples was measured showing a lineal variation with the mass ratio polymer-particle.3

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“…74 The temperature needs to be lower than the glass transition temperature to avoid plasticizing of the polymer particles. 75,76 In amorphous polymers, CO 2 molecules slip into the interstitial spaces of the polymers acting as lubricants and the polymers are plasticized. 8,76 Plasticizing causes particle coalescence and increases the particle size.…”

Section: Effects Of Pressure and Temperaturementioning

confidence: 99%

“…75,76 In amorphous polymers, CO 2 molecules slip into the interstitial spaces of the polymers acting as lubricants and the polymers are plasticized. 8,76 Plasticizing causes particle coalescence and increases the particle size. 75,76 In some polymers, especially amorphous polymers, the glass transition temperature may be decreased (4-30°C/MPa) after coming in contact with the supercritical fluid due to CO 2 activity within a very short time span because of the intermolecular interaction between the biodegradable polymer and dissolved supercritical fluid.…”

Section: Effects Of Pressure and Temperaturementioning

confidence: 99%

“…8,76 Plasticizing causes particle coalescence and increases the particle size. 75,76 In some polymers, especially amorphous polymers, the glass transition temperature may be decreased (4-30°C/MPa) after coming in contact with the supercritical fluid due to CO 2 activity within a very short time span because of the intermolecular interaction between the biodegradable polymer and dissolved supercritical fluid. 3,8,24,30 In a low-pressure region, the melting point of the biodegradable polymer during the SAS process decreases linearly due to the increased pressure.…”

Section: Effects Of Pressure and Temperaturementioning

confidence: 99%

See 1 more Smart Citation

Application of supercritical antisolvent method in drug encapsulation: a review

Kalani¹,

Yunus²

2011

IJN

117

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The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO 2 flow rate, and the liquid phase flow rate on particle size and its distribution.

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Coprecipitation of Cefuroxime Axetil–PVP composite microparticles by batch supercritical antisolvent process

Cited by 51 publications

References 74 publications

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

Titanium dioxide nanoparticle coating in fluidized bed via supercritical anti-solvent process (SAS)

Application of supercritical antisolvent method in drug encapsulation: a review

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