Cord blood procalcitonin in the assessment of early-onset neonatal sepsis

Salguero, O. Oria de Rueda; Mosquera, José Beceiro; González, Marta Barrionuevo; M, Crespo; Soria, C

doi:10.1016/j.anpede.2016.09.008

Cited by 4 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The best known risk factors for EOS are chorioamnionitis and maternal systemic infections. Preterm birth and preterm rupture of membranes are also other risk factors for chorioamnionitis and EOS [9].…”

Section: Discussionmentioning

confidence: 99%

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Çekmez

Güleçoğlu²,

Özcan³

et al. 2017

Ginekol Pol

View full text Add to dashboard Cite

Objectives: This study is aimed to evaluate the role of maternal mean platelet volume (MPV) levels for antenatal prediction marker of early onset neonatal sepsis in term infants born to mothers who have low infection risk. Material and methods:A total of 62 pregnant women who gave birth in our hospital and whose neonates were admitted to a third level Neonatal Intensive Care Unit due to confirmed neonatal sepsis between January 2010 and May 2016 were selected as a study group. Within the same period, 68 women who gave birth to healthy neonates were enrolled as a control group. We compared maternal MPV values which were evaluated before delivery. The receiver operating characteristic (ROC) curves were drawn to evaluate the values maternal MPV in the diagnosis of neonatal sepsis.Results: MPV levels were detected statistically higher in the study group than the control group (8.27 ± 1.85 vs. 8.98 ± 1.16) (p = 0.001). Conclusion:The maternal serum MPV level is a clinically useful, non-invasive and reliable marker in antenatal prediction of EOS.

show abstract

Section: Discussionmentioning

confidence: 99%

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Çekmez

Güleçoğlu²,

Özcan³

et al. 2017

Ginekol Pol

View full text Add to dashboard Cite

show abstract

“…The limitation of our study is its low sensitivity. Among 22 infected neonates, only 13 (59%) had a PCT value higher than 0.23 ng/ml, which is lower than that of other studies [16][17][18][19]. Recently, a meta-analysis including 17 reviews and 2197 episodes of suspected neonatal infection reported the sensitivity and specificity of umbilical cord blood PCT in diagnosis to be 82% and 86% [20].…”

Section: Discussionmentioning

confidence: 79%

Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection

Tran,

Giang,

Nguyen

2024

Cureus

View full text Add to dashboard Cite

Introduction: Early-onset neonatal infection (EONI) poses significant risks to neonatal health, necessitating reliable diagnostic markers for early detection. This study aims to evaluate the diagnostic validity of procalcitonin (PCT) concentration in umbilical cord blood as a biomarker for EONI. Methods: This prospective study was conducted at Ho Chi Minh University Medical Center from April 2022 to September 2022. The PCT level was measured in umbilical cord blood at birth. Based on clinical, laboratory, and microbiologic results, neonates were classified into infected and non-infected groups. Results: One hundred eighty neonates with risk factors for EONI were recruited. Among the neonates studied, 22 (12.2%) were classified as infected and 158 (87.8%) as non-infected by the classification criteria of clinical manifestations, laboratory tests, and blood culture. The median PCT in the infected group was significantly higher than that in the non-infected group (0.389 ng/mL vs. 0.127 ng/mL, p = 0.007). The optimal PCT cut-off was found by receiver operating characteristic (ROC) to be 0.23 ng/mL, with an area under the curve (AUC) of 0.87. The results were 59.1%, 98.7%, 86.2%, 94%, 45, and 0.41 for sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios, respectively. The post-test probability was 86% if the test was positive and 5% if it was negative. Conclusion: Umbilical cord blood PCT might be a reliable marker in the diagnosis of EONI, and its value helps limit the harmful effects of unnecessary prescriptions in non-infected neonates. However, considering the low sensitivity of procalcitonin, further research is necessary to fully integrate this biomarker into clinical practice.

show abstract

“…The limitation of our study is its low sensitivity. Among 22 infected neonates, only 13 neonates (59%) had a PCT value higher than 0.23 ng/ml, which is lower than that of other studies [16–19]. Recently, a meta-analysis including 17 reviews and 2197 episodes of suspected neonatal infection reported the sensitivity and specificity of umbilical cord blood PCT in diagnosis being 82% and 86% [20].…”

Section: Discussionmentioning

confidence: 99%

Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection

Tran,

Giang,

Nguyen

2024

Preprint

View full text Add to dashboard Cite

Introduction: Early-onset neonatal infection (EONI) poses significant risks to neonatal health, necessitating reliable diagnostic markers for early detection. This study aims to evaluate the diagnostic validity of procalcitonin (PCT) concentration in umbilical cord blood as a biomarker for EONI. Methods: This prospective study was conducted at Ho Chi Minh University Medical Center from April 2022 to September 2022. One hundred eighty neonates with risk factors for EONI were recruited. The PCT level was measured in umbilical cord blood at birth. Based on clinical, laboratory, and microbiologic results, neonates were classified into infected and non-infected groups. Results: Among the neonates studied, 22 (12.2%) were classified as infected and 158 (87.8%) as non-infected. The median PCT in the infected group was significantly higher than that in the non-infected group (0.389 ng/mL vs 0.127 ng/mL, p = 0.007). The optimal PCT cut-off was found by Receiver Operating Characteristic (ROC) to be 0.23 ng/mL, with an area under the curve of 0.87. The results were 59.1%, 98.7%, 86.2%, 94%, 45, and 0.41 for sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, respectively. The post-test probability was 86% if the test was positive and 5% if it was negative. Conclusion: Umbilical cord blood PCT is a reliable marker in the diagnosis of EONI, and its value helps limit the harmful effects of unnecessary prescriptions in non-infected neonates.

show abstract

Cord blood procalcitonin in the assessment of early-onset neonatal sepsis

Cited by 4 publications

References 33 publications

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

The utility of maternal mean platelet volume levels for early onset neonatal sepsis prediction of term infants

Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection

Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection

Contact Info

Product

Resources

About