Cord blood unit bankability can be predicted by prenatal sonographic parameters

Cobellis, Luigi; Castaldi, Maria Antonietta; Trabucco, Elisabetta; Imparato, Giorgia; Perricone, F.; Frega, V.; Signoriello, Giuseppe; Colacurci, Nicola

doi:10.1016/j.ejogrb.2013.07.038

Cited by 7 publications

(22 citation statements)

References 43 publications

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“…Seventeen articles showed that UCB volume was not associated with gestational age in any significant way . Interestingly, some positive correlation was found in seven articles …”

Section: Highlighted Factorsmentioning

confidence: 96%

Associated factors of umbilical cord blood collection quality

et al. 2017

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After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection.

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“…Seventeen articles showed that UCB volume was not associated with gestational age in any significant way . Interestingly, some positive correlation was found in seven articles …”

Section: Highlighted Factorsmentioning

confidence: 96%

Associated factors of umbilical cord blood collection quality

et al. 2017

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“…[121][122][123][124][125][126] Not surprisingly, the likelihood of both CBU use and transplant success is greatest among high-TNC count units. 81,121,[127][128][129] Among all transplanted CBUs from NMDP data from 2007 to 2016, only 11 percent had a TNC count below 1.25×10 9 (see Figure 7.1).…”

Section: Tnc%count%mentioning

confidence: 99%

Challenges to the Sustainability of the U.S. Public Cord Blood System

Kapinos¹,

Briscombe²,

Gračner³

et al. 2017

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“…Our data also demonstrated that the neonatal birth weight was correlated with the UCB volume. A previous study in the Italian population suggested that sonographic parameters such as fetal abdominal circumference and femur length may be used to predict UCB unit bankability (6). A further research in the Thai population to validate fetal biometric measurement for predicting UCB volume could also be beneficial.…”

Section: Discussionmentioning

confidence: 99%

“…In cord blood banking, the qualified cord blood unit was determined by the number of the total nucleated cell count (TNC) and the cluster of differentiation 34+ (CD34+) cell concentration that is adequate for engraftment (4). For an efficient banking system, some researchers look for a reliable method to predict UCB cell yield from volunteer cord blood donors (5)(6)(7). Several maternal and neonatal factors may influence the quantity and quality of UCB collection; for example, gestational age, neonatal birth weight, placental weight, route of delivery, and length of umbilical cord (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Correlation of ultrasound estimated placental volume and umbilical cord blood volume in term pregnancy

Pannopnut

Kitporntheranunt

Paritakul

et al. 2015

J Turkish German Gynecol Assoc

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Results: A total of 35 pregnant women were eligible for the study. The mean and standard deviation of estimated placental volume and actual placental volume were 534±180 mL and 575±118 mL, respectively. The median UCB volume was 140 mL (range 98-220 mL). The UCB volume did not have a statistically significant correlation with the estimated placental volume (correlation coefficient 0.15; p=0.37). However, the UCB volume was significantly correlated with the actual placental volume (correlation coefficient 0.62; p<0.001) and birth weight (correlation coefficient 0.38; p=0.02). Conclusion:The estimated placental volume by 2D ultrasound was not significantly correlated with the UCB volume. Further studies to establish the correlation between the UCB volume and the estimated placental volume using other types of placental imaging may be needed. Material and MethodsThis study is a cross-sectional study. The study population was singleton term pregnant women who had spontaneous vaginal delivery in our hospital from January 2014 to April 2014. The study protocol was approved by the ethical review board. A pilot study of 10 pregnant women was performed. After data collection, the sample size was calculated using the expected correlation coefficient (r) of 0.74. This study required at least 35 participants.

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Cord blood unit bankability can be predicted by prenatal sonographic parameters

Cited by 7 publications

References 43 publications

Associated factors of umbilical cord blood collection quality

Associated factors of umbilical cord blood collection quality

Challenges to the Sustainability of the U.S. Public Cord Blood System

Correlation of ultrasound estimated placental volume and umbilical cord blood volume in term pregnancy

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