Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis

Belderbos, Mirjam E.; Houben, Michiel L.; Wilbrink, B.; Lentjes, Eef G.W.M.; Bloemen, Eltje M.; Kimpen, Jan L. L.; Rovers, Maroeska M.; Bont, Louis

doi:10.1542/peds.2010-3054

Cited by 312 publications

(285 citation statements)

References 51 publications

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“…The findings of the study by El-Mazary et al [19], in infants who lived in urban areas and with dark skin (factors that increase the incidence of vitamin D deficiency due to less exposure to sunlight), agree with a randomized double blind study performed in 2012, with adults who had immunodeficiency, which demonstrated that vitamin D intake reduced the risk of acute LRTI, frequent in the winter [20] R. In addition to these studies, there are other evidences such as a prospective cohort study conducted by Belderbos et al [21], which demonstrated that healthy newborns with vitamin D deficiency had an increased risk for LRTI, especially AVB caused by RSV in the first year of life. Recently, two systematic reviews demonstrated that vitamin D intake reduced significantly the risk of respiratory tract infections; however, these reviews did not assess the direct association between vitamin D and AVB [16,22].…”

Section: Discussionsupporting

confidence: 70%

Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática

Rueda

Sarria-Icaza

Scottá

et al. 2015

Sci Med

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Aims: Published evidence suggests that Vitamin D supplementation may have a protective effect on infectious disease of the lower respiratory tract. The objective of this review was to critically appraise the effects of vitamin D intake in the prevention of acute viral bronchiolitis in children. Methods: We searched the databases Medline, EMBASE, Web of Science, LILACS, and Cochrane Central Register of Controlled Trials, until December 2014, using the keywords: "Vitamin D" or cholecalciferol or ergocalciferol and "bronchiolitis, viral" or "viral bronchiolitis" or "bronchiolitides, viral" or "viral bronchiolitides". Studies evaluating the effect of vitamin D intake in the prevention of acute viral bronchiolitis in young children were included. Studies with less than two weeks of intervention and review articles were excluded. Results: The search identified 241 articles, among which 20 articles were selected for full reading and two articles were included in the systematic review, comprising 296 children. No study measured serum levels of vitamin D. One of the included studies was a clinical trial, where the number of episodes of acute viral bronchiolitis was significantly lower in children supplemented with vitamin D (Group I: mean 0.6±0.7 Group II: mean 1.4±0.9; P=0.001). The other, a case-control study, did not find a significant relationship between the occurrence of acute viral bronchiolitis cases and the intake of vitamin D (odds ratio 1.7, 95% confidence interval 0.7-4.0). Conclusions: Current scientific evidence is insufficient to prove clinical benefits of vitamin D in preventing acute viral bronchiolitis.KEY WORDS: vitamin D; bronchiolitis, viral; infant; child. RESUMOObjetivos: Evidências publicadas sugerem que a suplementação da vitamina D pode ter efeito protetor nas infecções do trato respiratório inferior. O objetivo desta revisão foi avaliar os efeitos da ingestão de vitamina D na prevenção da bronquiolite viral aguda em crianças. Métodos: Foram feitas buscas nas bases de dados Medline, EMBASE, Web of Science, LILACS e Cochrane Central Register of Controlled Trials, até dezembro de 2014, usando os descritores "Vitamin D" ou cholecalciferol ou ergocalciferol e "bronchiolitis, viral" ou "viral bronchiolitis" ou "bronchiolitides, viral" ou "viral bronchiolitides". Foram incluídos estudos que avaliaram o efeito da ingesta da vitamina D na prevenção da bronquiolite viral aguda em crianças. Estudos com intervenção menor que duas semanas e artigos de revisão foram excluídos. Resultados: A busca identificou 241 artigos, entre os quais 20 artigos foram selecionados para leitura na íntegra e dois artigos foram incluídos na revisão sistemática, incluindo 296 crianças. Nenhum estudo mediu os níveis séricos de vitamina D. Um dos estudos incluídos foi um ensaio clinico, no qual o número de episódios de bronquiolite foi significativamente menor nas crianças suplementadas com vitamina D (Grupo I: média 0,6±0,7 Grupo II: média 1,4 ±0,9; P=0,001). No outro, um estudo de casos e controles, não se encontrou rel...

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Section: Discussionsupporting

confidence: 70%

Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática

Rueda

Sarria-Icaza

Scottá

et al. 2015

Sci Med

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“…Both swabs were collected into a single vial containing GLY medium with 0.1 mg?mL -1 pimaricin as the viral transport medium and sent to our laboratory via standard mail. Samples were stored at -20uC until analysis [17]. RSV positivity was defined as having a RSV PCR-positive swab in the first year of life.…”

Section: Rsv Positivitymentioning

confidence: 99%

Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants

et al. 2014

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It is unknown why respiratory syncytial virus (RSV) causes mild disease in some children and severe disease, requiring hospitalisation, in others. We aimed to assess whether diminished premorbid lung function in healthy term infants predisposes to hospitalisation during RSV bronchiolitis, and to post-RSV wheeze.In a prospective birth cohort study of unselected term healthy children, neonatal lung function was measured before the age of 2 months (n52133). From birth through the first year of life, respiratory symptoms were recorded in a diary, and general practitioner consultations and hospitalisations were documented. In a subgroup (n5417) repeated nose and throat swabs were collected for PCR to detect RSV infections.Median neonatal respiratory system compliance (Crs) was significantly lower (41.2 versus 47.4 mL?kPa -1 , p50.03) and resistance (Rrs) was higher (8.2 versus 6.3 kPa?s?L -1 , p50.10) in hospitalised RSV patients (n518) compared with nonhospitalised RSV-positive infants (n584). Every 10 mL?kPa -1 increase in Crs was associated with 55% less post-RSV wheeze (OR 0.56, 95% CI 0.35-0.90), and each kPa?s?L -1 increase in Rrs was associated with 42% more post-RSV wheeze, which was only marginally explained by pre-RSV wheeze or severity of the RSV disease.This unselected birth cohort study shows for the first time that decreased lung function at birth predisposes to severe RSV disease, and to post-RSV wheeze. @ERSpublications Impaired neonatal lung function precedes a severe course of RSV infection in unselected children

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“…41 Infecciones del tracto respiratorio y DVD: Durante el primer año de vida, hay un mayor riesgo de presentar bronquiolitis por virus respiratorio sincicial (VRS) cuando las concentraciones de VD en sangre de cordón son < 50 nmol/L. 42 Estudios realizados en Alemania por Łuczyńska et al, 43 reportaron que el riesgo de infección respiratoria aguda baja (IRAB) aumentaba alrededor del doble en aquellos lactantes con concentraciones de VD < 25 nmol/L en sangre de cordón. Además, parece haber una relación entre la DVD y la mayor gravedad de bronquiolitis por VRS.…”

Section: Asmaunclassified

Deficiencia de vitamina D en la práctica clínica pediátrica

2018

Arch Argent Pediatr

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Cord Blood Vitamin D Deficiency Is Associated With Respiratory Syncytial Virus Bronchiolitis

Abstract: Vitamin D deficiency in healthy neonates is associated with increased risk of RSV LRTI in the first year of life. Intensified routine vitamin D supplementation during pregnancy may be a useful strategy to prevent RSV LRTI during infancy.

Cited by 312 publications

References 51 publications

Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática

Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática

Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants

Deficiencia de vitamina D en la práctica clínica pediátrica

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