Cord Serum Ferritin Concentrations and Mental and Psychomotor Development of Children at Five Years of Age

Tamura, Tsuneobu; Goldenberg, Robert L.; Hou, Jue; Johnston, Kelle E.; Cliver, Suzanne P.; Ramey, Sharon L.; Nelson, Kathleen G.

doi:10.1097/00006254-200208000-00008

Cited by 98 publications

(133 citation statements)

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“…Tamura et al [27] reported that the five year old children of mothers with ID in the last 207 trimester of pregnancy (i.e. cord serum ferritin <76 mcg/L), had significantly lower scores 208 on tests of auditory language comprehension and ability to follow instructions compared to 209 children whose mothers did not have ID.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Effects of anemia at different stages of gestation on infant outcomes

et al. 2016

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Section: Accepted Manuscriptmentioning

confidence: 99%

Effects of anemia at different stages of gestation on infant outcomes

et al. 2016

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“…Early iron deficiency can cause irreversible brain damage at cellular and neuronal levels, thus have a profound long-term effect on brain function (Youdim 2000). Iron deficiency in children is associated with difficulties in performing cognitive tasks and retardation in the development of the CNS (Benton 2001, Tamura et al 2002. A large literature links iron deficiency and overload to cognitive impairment in humans (Grantham-McGregor and Ani 2001, Beard and Connor 2003, Gordon 2003, including AD Perry 1995, Smith et al 2002) and PD (Berg et al 2001).…”

Section: Deficiency and Supplementation Of Individual Mt-nutrients Inmentioning

confidence: 99%

Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease

Liu¹,

Ames²

2005

Nutritional Neuroscience

127

116

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Mitochondrial decay due to oxidative damage is a contributor to brain aging and age-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). One type of mitochondrial decay is oxidative modification of key mitochondrial enzymes. Enzyme dysfunction, that is due to poor binding of substrates and coenzymes may be ameliorated by supplementing adequate levels of substrates or coenzyme precursors. Such supplementation with mitochondrial nutrients (mt-nutrients) may be useful to prevent or delay mitochondrial decay, thus prevent or treat AD and PD. In the present review, we survey the literature to identify mt-nutrients that can (1) protect mitochondrial enzymes and/or stimulate enzyme activity by elevating levels of substrates and cofactors; (2) induce phase-2 enzymes to enhance antioxidant defenses; (3) scavenge free radicals and prevent oxidant production in mitochondria, and (4) repair mitochondrial membrane. Then, we discuss the relationships among mt-nutrient deficiency, mitochondrial decay, and cognitive dysfunction, and summarize available evidence suggesting an effect of mt-nutrient supplementation on AD and PD. It appears that greater effects might be obtained by longer-term administration of combinations of mt-nutrients. Thus, optimal doses of combinations of mt-nutrients to delay and repair mitochondrial decay could be a strategy for preventing and treating cognitive dysfunction, including AD and PD.

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“…de Andraca et al (1990) reported links with global IQ and language abilities. Tamura et al (2002) replicated these findings among 278 five-year-old children. Those who had umbilical cord serum ferritin concentrations in the lowest quartile scored significantly lower than the rest of the sample on language and fine motor skills.…”

Section: Main Effects Ironmentioning

confidence: 64%

Main and Interaction Effects of Iron, Zinc, Lead, and Parenting on Children's Cognitive Outcomes

Hubbs‐Tait

Mulugeta

Bogale

et al. 2009

Developmental Neuropsychology

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This study examined relations of blood lead < 10 microg/dL, iron, zinc, and parenting to Head Start children's (N = 112) scores on Peabody Picture Vocabulary Test-III (PPVT-III) and McCarthy Scales of Children's Abilities (MSCA). Venous whole blood and plasma samples were analyzed for lead and zinc by ICP-MS and iron status was assessed by serum transferrin receptors. Hierarchical regressions revealed significant effects of lead on MSCA perceptual scores and iron on PPVT-III and MSCA verbal scores. Children with lead > 2.5 microg/dL had significantly lower MSCA perceptual scores than children < 2.5 microg/dL. Permissive parenting significantly exacerbated negative effects of higher lead or lower iron on children's perceptual or verbal scores, respectively.

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Cord Serum Ferritin Concentrations and Mental and Psychomotor Development of Children at Five Years of Age

Cited by 98 publications

References 0 publications

Effects of anemia at different stages of gestation on infant outcomes

Effects of anemia at different stages of gestation on infant outcomes

Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease

Main and Interaction Effects of Iron, Zinc, Lead, and Parenting on Children's Cognitive Outcomes

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