Main and Interaction Effects of Iron, Zinc, Lead, and Parenting on Children's Cognitive Outcomes

Hubbs‐Tait, Laura; Mulugeta, Afework; Bogale, Alemtsehay; Kennedy, Tay; Baker, Eric R.; Stoecker, Barbara J.

doi:10.1080/87565640802646759

Cited by 26 publications

(18 citation statements)

References 95 publications

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“…Plasma levels of copper ( 63 Cu & 65 Cu), iron ( 54 Fe & 57 Fe), manganese ( 55 Mn), selenium ( 82 Se), and zinc ( 66 Zn) were measured using inductively coupled plasma quadrupole mass spectroscopy (Elan 9000; Perkin Elmer, Norwalk, CT) as described. 30 All plasma samples were diluted 20-fold (200 μL diluted to 4 mL) with 0.1% nitric oxide (GFS Chemicals, Powell, OH) in ultra-pure water. Standard solutions of selected trace elements were prepared by dilution of certified standard solutions (Perkin Elmer, Norwalk, CT).…”

Section: Methodsmentioning

confidence: 99%

Trace elements as predictors of preeclampsia in type 1 diabetic pregnancy

Basu

Jenkins

et al. 2015

Nutrition Research

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Preeclampsia (PE) affects approximately 5% of all pregnancies, but is increased several-fold in women with pre-gestational type 1 diabetes mellitus (T1DM). Increased oxidative stress and altered maternal plasma trace elements that modulate the antioxidant system have been implicated in PE. In non-diabetic women, increased plasma copper and iron, and decreased manganese, selenium, and zinc have been associated with PE in cross-sectional studies. In a longitudinal study, we hypothesized that plasma levels of trace elements differ between T1DM women with vs. without subsequent PE. Samples were collected during the first (gestation 12.2 ± 1.9 weeks, (mean ± SD)), second (21.6 ± 1.5 weeks), and third (31.5 ± 1.7 weeks) trimesters of pregnancy, all before the onset of PE. We compared 23 T1DM women who subsequently developed PE with 24 T1DM women who remained normotensive; and we included 19 non-diabetic (non-DM) normotensive pregnant women as reference controls. Trace elements were measured using inductively coupled plasma mass spectroscopy (ICP-MS). In T1DM women with subsequent PE vs. normotensive, only plasma zinc was significantly higher at the first trimester, while copper:zinc and copper:HDL-cholesterol ratios were higher throughout gestation (all p<0.05). These findings persisted after adjustment for covariates. Higher copper:zinc ratios may contribute to oxidative stress in T1DM women who develop PE. Ratio of pro-to anti-oxidant factors may predict risk for PE in diabetic pregnancies more effectively than individual trace element levels.

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Section: Methodsmentioning

confidence: 99%

Trace elements as predictors of preeclampsia in type 1 diabetic pregnancy

Basu

Jenkins

et al. 2015

Nutrition Research

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“…Of these three studies, two tested mediation models evaluating if effects of SES were mediated by lead exposures [29,30] and one considered lead as modifying the influence of the psychosocial exposure (maternal self-esteem) [37]. In terms of the environmental exposures, eight examined metals [29,30,34,35,[37][38][39][40], one considered organophosphate exposures [31], two examined PCBs and/or dioxin exposure [36,41], one considered tobacco smoke [32], one examined traffic-related black carbon [28], and one considered airborne polycyclic aromatic hydrocarbons [33•]. For the social factors, five considered a range of psychosocial factors and stressors (e.g., negative life events, maternal distress, parenting behaviors, cognitive stimulation in the home) [28, 31, 33•, 36, 40], five focused solely on SES [29,30,32,39,41], one examined both SES and psychosocial factors as separate modifiers [35,38], and two studies considered maternal self-esteem [34,37].…”

Section: Cognitive and Behavioral Outcomesmentioning

confidence: 99%

“…For the social factors, five considered a range of psychosocial factors and stressors (e.g., negative life events, maternal distress, parenting behaviors, cognitive stimulation in the home) [28, 31, 33•, 36, 40], five focused solely on SES [29,30,32,39,41], one examined both SES and psychosocial factors as separate modifiers [35,38], and two studies considered maternal self-esteem [34,37]. Twelve studies tested effect modification hypotheses, and of those that did so, ten (83 %) observed synergistic associations between environmental and social/psychosocial exposures for child cognitive and behavioral risk [28,[32][33][34][35][36][37][38][39][40]. Two other studies found lead exposure to mediate the association between early-life SES and biomarker-assessed stress reactivity in childhood [29,30].…”

Section: Cognitive and Behavioral Outcomesmentioning

confidence: 99%

“…Of these, nine considered cognitive developmental outcomes and skills [28,31,32,[34][35][36][38][39][40], three examined behavior problems [33•, 37, 41], and two focused on biomarker-based stress reactivity [29,30]. All but three conceptualized social and psychosocial factors as modifying the influence of the environmental exposure.…”

Section: Cognitive and Behavioral Outcomesmentioning

confidence: 99%

“…Of the 14 studies that considered the joint contribution of social and environmental exposures in relation to cognitive and behavioral outcomes in childhood, 12 were individual-level prospective cohort designs [28][29][30][31][32][33][34][35][36][37][38][39], and two were cross-sectional [40,41] ( Table 2). Of these, nine considered cognitive developmental outcomes and skills [28,31,32,[34][35][36][38][39][40], three examined behavior problems [33•, 37, 41], and two focused on biomarker-based stress reactivity [29,30].…”

Section: Cognitive and Behavioral Outcomesmentioning

confidence: 99%

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A Systematic Review of the Interplay Between Social Determinants and Environmental Exposures for Early-Life Outcomes

Appleton

Holdsworth

Kubzansky

2016

Curr Envir Health Rpt

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Forty-one studies met the search criteria and were reviewed. Of these, 37, 34, and 29 % of studies focused on asthma, cognition/behavior, and perinatal outcomes, respectively. No study focused on obesity. Across all studies reviewed, 72 % observed significant synergistic associations between social and environmental exposures. Air pollution was the most frequently studied environmental exposure, and socioeconomic status was the most commonly studied social factor. The emerging evidence suggests that social and environmental risks may jointly affect child health. Recommendations for future research are discussed, including enhancing characterization of the social environment and broadening the types of environmental risks assessed.

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Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study

et al. 2023

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BackgroundResearch on the neurodevelopmental effects of metal/metalloids has focused mainly on outcomes assessed at one time point, even though brain development progresses over time. We investigated biomarkers of perinatal exposure to metal/loids and changes in child behavior over time. MethodsWe followed 268 participants from the prospective New Hampshire Birth Cohort Study between birth and age ve years. We measured arsenic (As), copper (Cu), manganese (Mn), lead (Pb), selenium (Se) and zinc (Zn) in toenails from 6-week-old infants. The Behavioral Symptoms Index (BSI), externalizing, and internalizing symptoms were assessed using the Behavior Assessment System for Children, 2nd edition (BASC-2) at ages 3 and 5 years. Multivariable linear regression was used to estimate associations of metal/loids with behavior change, calculated as the difference in symptom raw scores between 3 and 5 years, in addition to the associations for symptom scores at 3 and 5 years separately. Sex-speci c associations were also explored using strati ed models and a sex-metal interaction term. ResultsAdjusted associations of metal/loids and change in behavior varied by exposure and outcome. Each 1 µg/g increase in toenail Cu was associated with improved behavior between 3 and 5 years [BSI: β= -3.88 (95%CI: -7.12, -0.64); Externalizing problems: β = -2.20 (95%CI: -4.07, -0.33)]. Increasing Zn was associated with increased externalizing behavior over time (β = 3.42 (95%CI: 0.60, 6.25). Sex-strati ed analyses suggested more pronounced associations among boys compared to girls. ConclusionsPerinatal exposure to metal/loids may alter behavioral development between ages 3 and 5 years.Findings support the need for more research on associations between metal/loids and neurodevelopment over longer time periods.

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Main and Interaction Effects of Iron, Zinc, Lead, and Parenting on Children's Cognitive Outcomes

Cited by 26 publications

References 95 publications

Trace elements as predictors of preeclampsia in type 1 diabetic pregnancy

Trace elements as predictors of preeclampsia in type 1 diabetic pregnancy

A Systematic Review of the Interplay Between Social Determinants and Environmental Exposures for Early-Life Outcomes

Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study

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