Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age

Tamura, Tsunenobu; Goldenberg, Robert L.; Hou, Jue; Johnston, Kelley E.; Cliver, Suzanne P.; Ramey, Sharon L.; Nelson, Kathleen G.

doi:10.1067/mpd.2002.120688

Cited by 303 publications

(149 citation statements)

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“…Together with the studies of Tamura et al 19 and Siddappa et al, 22 our study indicates that prenatal or very early postnatal iron status is related to short-and/or long-term neurobehavioral outcomes in human beings. Further studies with more specific measures of neurodevelopment and potential confounders are needed to confirm the exact nature of the causal relations between low iron status and neurological impairments in premature infants.…”

Section: Discussionsupporting

confidence: 84%

“…Previous studies have noted that normal term infant ferritin levels are much higher than that found in later infancy, and the normal values of term newborn cord serum ferritin concentration was defined as between 70 and 76 mg/l. 19,32 Other studies have set the target levels of serum ferritin in irontreated premature infants as over 100 mg/l. 33,34 Thus, for this study we defined 'low ferritin' concentrations as r75 mg/l.…”

Section: Subjects and Methods Participantsmentioning

confidence: 99%

“…In such models, decreases in brain iron content have been associated with electrophysiological alterations, impaired dopaminergic function, decreased cytochrome c oxidase activity, abnormal dendritic morphology, impaired myelin production, and long-term behavioral changes. [9][10][11][12][13][14][15][16][17][18] Tamura et al 19 has reported that cord serum ferritin levels in term human newborn infants correlated with ultimate cognitive function at 5 years of age. While such correlations do not confirm the causal relationship, given the multiple confounders in such study populations (as noted by Fleming,20 and Beard and Connor 21 ), these data suggest the importance of iron status for the developing brain.…”

Section: Introductionmentioning

confidence: 99%

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Iron Status and Neurobehavioral Development of Premature Infants

et al. 2004

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Section: Discussionsupporting

confidence: 84%

Section: Subjects and Methods Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Iron Status and Neurobehavioral Development of Premature Infants

et al. 2004

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“…Hemolyzed RBCs release non-protein bound free iron that is implicated in poor neurodevelopment. 2,3 In addition, high total plasma bilirubin has been associated with kernicterus, although this association is not as clear-cut as the association of plasma-free bilirubin with neurotoxicity. 4 These concerns led us to investigate variables pre-and during ECMO that might affect RBC hemolysis after ECMO, namely the saline pre-washing of the blood used for the ECMO, and the kind of pump used during ECMO.…”

Section: Discussionmentioning

confidence: 99%

Increased hemolysis from saline pre-washing RBCs or centrifugal pumps in neonatal ECMO

et al. 2007

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Objectives: Hemolysis is a significant complication of extracorporeal membrane oxygenation (ECMO), with a reported incidence of 12.2%. The aims of this study were (1) to investigate hemolysis caused by saline-washed versus unwashed RBCs, (2) to determine in vitro the effects of saline washing on erythrocyte hemolytic markers and (3) to investigate hemolysis by centrifugal versus roller pumps.Study design: (1) To evaluate the effect of pre-transfusion saline-washing versus non-washing, the peak plasma-free hemoglobin (FHb) and total bilirubin in the first 3 days versus the next 4 days of ECMO were compared (2) Pre-and postsaline-washed RBCs were analyzed for K þ , hemoglobin, mean corpuscular volume, FHb and hemolysis at baseline and after 4 h of storage at 41C. (3) Over 10 000 neonatal ECMO cases were retrospectively reviewed to study the effect of pump type on hemolysis.Results: (1) The washed blood group had significantly more hemolysis within the first 3 days of ECMO. (2) Immediately after saline washing, the K þ and Hb concentrations were significantly decreased compared with unwashed blood, and these differences were maintained after 4 h. The osmotic fragility of washed RBCs after 4 h of storage at 41C was significantly higher than at baseline. (3) Hemolysis was reported more often in the centrifugal than in the roller pump group.Conclusions: (1) Using unwashed RBCs decreased hemolysis within the first 3 days of ECMO. (2) Saline washing, while decreasing the concentration of K þ in the plasma, significantly increases RBC membrane osmotic fragility. (3) Hemolysis is linked to the use of centrifugal pumps.

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“…Numerous studies suggest that deficiencies of key micronutrients during the brain growth spurt, which occurs in the last trimester of pregnancy and the first 2 years of life, may have lasting effects on neurodevelopment (1)(2)(3)(4)(5)(6)(7)(8)(9) . Among these nutrients, there is evidence that several long-chain PUFA, particularly the n-3 fatty acid DHA, may be essential for optimal brain function.…”

mentioning

confidence: 99%

Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years

Mendez

Torrent

Júlvez

et al. 2009

Public Health Nutr.

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Objective: To analyse the relationship between maternal intakes of fish and other seafood during pregnancy and child neurodevelopment at age 4 years. Although pregnant women are advised to limit seafood intakes because of possible neurotoxin contamination, several studies suggest that overall maternal seafood intakes are associated with improved child neurodevelopment, perhaps because of higher DHA intakes. Design: The study uses data from a prospective birth cohort study. Maternal seafood intakes were assessed using a semi-quantitative FFQ administered shortly after delivery. Multivariate linear regression was used to estimate associations between seafood consumption and scores on the McCarthy Scales of Children's Abilities (MCSA). Analyses were stratified by breast-feeding duration as breast milk is a source of DHA during the postnatal phase of the brain growth spurt. Setting: Menorca, Spain, 1997-2001. Subjects: Full-term children (n 392) with data on maternal diet in pregnancy, breast-feeding duration and neurodevelopment at age 4 years. Results: Among children breast-fed for ,6 months, maternal fish intakes of .2-3 times/week were associated with significantly higher scores on several MCSA subscales compared with intakes #1 time/week. There was no association among children breast-fed for longer periods. Maternal intakes of other seafood (shellfish/squid) were, however, inversely associated with scores on several subscales, regardless of breast-feeding duration.Conclusions: The study suggests that moderately high intakes of fish, but not other seafood, during pregnancy may be beneficial for neurodevelopment among children breast-fed for ,6 months. Further research in other populations with high seafood intakes and data on additional potential confounders are needed to confirm this finding.

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Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age

Cited by 303 publications

References 40 publications

Iron Status and Neurobehavioral Development of Premature Infants

Iron Status and Neurobehavioral Development of Premature Infants

Increased hemolysis from saline pre-washing RBCs or centrifugal pumps in neonatal ECMO

Maternal fish and other seafood intakes during pregnancy and child neurodevelopment at age 4 years

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