Cord serum metabolic signatures of future progression to immune-mediated diseases

Hyötyläinen, Tuulia; Karthikeyan, Bagavathy Shanmugam; Ghaffarzadegan, Tannaz; Triplett, Eric W.; Orešič, Matej; Ludvigsson, Johnny

doi:10.1016/j.isci.2023.106268

Cited by 3 publications

(8 citation statements)

References 42 publications

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“…This comprehensive approach allowed us to assess the combined impact of environmental exposures and metabolic profiles on autoimmune diseases in the ABIS cohort. In our previous study we found similarities in metabolic profiles across different autoimmune diseases at birth (Hyotylainen et al 2023). In order to avoid class imbalance problems, here we pooled all individual diseases together.…”

Section: Discussionmentioning

confidence: 99%

“…ABIS is connected to the Swedish National Diagnosis Register which give information about diagnosis of autoimmune disease. Stool samples were collected from ca 1800 individuals at 1 year of age, and microbiome studies have been performed (Belteky et al 2023;Hyotylainen et al 2023). The present study includes subjects (N=62) from this group who later developed one or more autoimmune and inflammatory diseases such as cCeliac disease (CD), Crohns disease (IBD), hypothyroidism (HT), juvenile idiopathic arthritis (JIA) and type1 diabetes (T1D) along with their matching controls (N=268).…”

Section: Methodsmentioning

confidence: 99%

“…To cluster the contaminant data, we utilized the ‘ mclust ’ R package (version 5.4.10) for model-based clustering, selecting the model type and the number of clusters based on the highest Bayesian Information Criterion (BIC). To better understand the impact of exposure, we also incorporated lipidomics and metabolomics data from our previous study (Hyotylainen et al 2023), which included eight lipid clusters (LCs) and twelve polar metabolite clusters (PCs), along with their individual features.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 360 cord blood samples were randomized and analyzed as described below. Shortly, two methods were applied for separate extraction of lipids and polar/semipolar metabolites and the extracts were then analyzed using an ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOFMS) as described previously (Hyotylainen et al 2023) and the data were processed using MZmine 2.53 (Pluskal et al 2010). Quantification was performed using calibration curves and the identification was done with a custom data base, with identification levels 1 and 2 (Metabolomics Standards Initiative).…”

Section: Analysis Of Metabolome and Environmental Contaminantsmentioning

confidence: 99%

“…Given the potential impact of exposure to environmental contaminants and the role of maternal factors in the progression of autoimmune diseases (Hyotylainen et al 2023), it is important to characterize the prenatal and early-life exposome to better understand the pathogenesis of autoimmune diseases. Herein, we hypothesized that exposure to environmental contaminants impacts cord serum metabolome, which may contribute to the development of one or more autoimmune diseases in the general population cohort (All Babies In Southeast Sweden, ABIS) (Ludvigsson et al 2001; Nygren et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to environmental contaminants is associated with altered cord serum metabolite profiles in future immune-mediated diseases

Karthikeyan,

Hyötyläinen,

Ghaffarzadegan

et al. 2023

Preprint

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Prenatal exposure to environmental contaminants is a significant health concern because it has the potential to interfere with host metabolism, leading to adverse health effects in early childhood and later in life. Growing evidence suggests that genetic and environmental factors, as well as their interactions, play a significant role in the development of autoimmune diseases. In this study, we hypothesized that prenatal exposure to environmental contaminants impacts cord serum metabolome and contributes to the development of autoimmune diseases. We selected cord serum samples from All Babies in Southeast Sweden (ABIS) general population cohort, from infants who later developed one or more autoimmune-mediated and inflammatory diseases: celiac disease (CD), Crohn’s disease (IBD), hypothyroidism (HT), juvenile idiopathic arthritis (JIA), and type 1 diabetes (T1D) (all cases, N = 62), along with matched controls (N = 268). Using integrated exposomics and metabolomics mass spectrometry (MS) based platforms, we determined the levels of contaminants and metabolites. Differences in exposure levels were found between the controls and those who later developed various diseases. High contaminant exposure levels were associated with changes in metabolome, including amino acids and free fatty acids. Specifically, we identified marked associations between metabolite levels and exposure levels of deoxynivalenol (DON), bisphenol S (BPS), and specific per- and polyfluorinated substances (PFAS). Our study suggests that prenatal exposure to specific environmental contaminants alters the cord serum metabolomes, which, in turn, might increase the risk of various immune-mediated disease later in life.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Analysis Of Metabolome and Environmental Contaminantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prenatal exposure to environmental contaminants is associated with altered cord serum metabolite profiles in future immune-mediated diseases

Karthikeyan,

Hyötyläinen,

Ghaffarzadegan

et al. 2023

Preprint

Self Cite

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Associations of Pregnancy Dietary Quality and Diversity with Childhood Celiac Disease

Hård af Segerstad,

Borge,

Guo

et al. 2024

The Journal of Nutrition

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Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

Karthikeyan,

Hyötyläinen,

Ghaffarzadegan

et al. 2024

J Expo Sci Environ Epidemiol

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Background Prenatal exposure to environmental contaminants is a significant health concern because it has the potential to interfere with host metabolism, leading to adverse health effects in early childhood and later in life. Growing evidence suggests that genetic and environmental factors, as well as their interactions, play a significant role in the development of autoimmune diseases. Objective In this study, we hypothesized that prenatal exposure to environmental contaminants impacts cord serum metabolome and contributes to the development of autoimmune diseases. Methods We selected cord serum samples from All Babies in Southeast Sweden (ABIS) general population cohort, from infants who later developed one or more autoimmune-mediated and inflammatory diseases: celiac disease (CD), Crohn’s disease (IBD), hypothyroidism (HT), juvenile idiopathic arthritis (JIA), and type 1 diabetes (T1D) (all cases, N = 62), along with matched controls (N = 268). Using integrated exposomics and metabolomics mass spectrometry (MS) based platforms, we determined the levels of environmental contaminants and metabolites. Results Differences in exposure levels were found between the controls and those who later developed various diseases. High contaminant exposure levels were associated with changes in metabolome, including amino acids and free fatty acids. Specifically, we identified marked associations between metabolite profiles and exposure levels of deoxynivalenol (DON), bisphenol S (BPS), and specific per- and polyfluorinated substances (PFAS). Impact statement Abnormal metabolism is a common feature preceding several autoimmune and inflammatory diseases. However, few studies compared common and specific metabolic patterns preceding these diseases. Here we hypothesized that exposure to environmental contaminants impacts cord serum metabolome, which may contribute to the development of autoimmune diseases. We found differences in exposure levels between the controls and those who later developed various diseases, and importantly, on the metabolic changes associated with the exposures. High contaminant exposure levels were associated with specific changes in metabolome. Our study suggests that prenatal exposure to specific environmental contaminants alters the cord serum metabolomes, which, in turn, might increase the risk of various immune-mediated diseases.

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Cord serum metabolic signatures of future progression to immune-mediated diseases

Cited by 3 publications

References 42 publications

Prenatal exposure to environmental contaminants is associated with altered cord serum metabolite profiles in future immune-mediated diseases

Prenatal exposure to environmental contaminants is associated with altered cord serum metabolite profiles in future immune-mediated diseases

Associations of Pregnancy Dietary Quality and Diversity with Childhood Celiac Disease

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases

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