Cordia verbenacea and secretion of mast cells in different animal species

Oliveira, Déborah Mara Costa de; Luchini, Ana Carolina; Seito, Leonardo Noboru; Gomes, José Carlos; Crespo-López, María Elena; Stasi, Luiz Cláudio Di

doi:10.1016/j.jep.2011.03.046

Cited by 15 publications

(11 citation statements)

References 29 publications

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“…In another study, C. verbenacea extract showed its histamine inhibitory activity by reducing histamine secretion from rat and guinea pig mast cells induced by ionophore A23187, concanavalin A, and the mast cell degranulating compound 48/80. The same study showed that the oral treatment inhibited the histamine secretion caused by ionophore A23187 in rats [73]. C. verbenacea essential oil and its main compounds already demonstrated anti-histamine effects in different in vivo models of allergy and inflammation [46,49,58].…”

Section: Discussionmentioning

confidence: 84%

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Melo

Saito

Vale

et al. 2021

Photochem Photobiol Sci

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Cordia verbenacea DC (Boraginaceae) is a flowering shrub found along the Brazilian Atlantic Forest, Brazilian coast, and low areas of the Amazon. The crude extract of its leaves is widely used in Brazilian folk medicine as an anti-inflammatory, both topically and orally. The aim of this study is to evaluate the activity of C. verbenacea ethanolic leaves extract (CVE) against UVB-triggered cutaneous inflammation and oxidative damage in hairless mice. CVE treatment recovered cutaneous antioxidant capacity demonstrated by scavenging ABTS + free radical and iron-reducing antioxidant potential evaluated by FRAP. CVE also controlled the following UV-triggered events in the skin: reduced glutathione (GSH) depletion, catalase activity decrease, and superoxide anion (O ⋅-) build-up. Furthermore, mice treated with CVE exhibited less inflammation, shown by the reduction in COX-2 expression, TNF-α, IL-1β, IL-6, edema, and neutrophil infiltration. CVE also regulated epidermal thickening and sunburn cells, reduced dermal mast cells, and preserved collagen integrity. The best results were obtained using 5% CVE-added emulsion. The present data demonstrate that topical administration of CVE presents photochemoprotective activity in a mouse model of UVB inflammation and oxidative stress. Because of the intricate network linking inflammation, oxidative stress, and skin cancer, these results also indicate the importance of further studies elucidating a possible role of C. verbenacea in the prevention of UVB-induced skin cancer and evaluating a potential synergy between CVE and sunscreens in topical products against UVB damaging effects to the skin.

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Section: Discussionmentioning

confidence: 84%

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Melo

Saito

Vale

et al. 2021

Photochem Photobiol Sci

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“…Cordia alliodora Cham., one of the most important timber trees in the Amazon, has an interesting chemical profile [5,6,7,8,9,10,11] with antimicrobial, antifungal, larvicidal [12] and cytotoxic activities [13] which have been experimentally tested. Cordia verbenaceae DC has been studied as anti-inflammatory [14], analgesic [15], antibacterial [16], antiallergic [17] and antitumoral [18]; the latter activity is attributed to the rosmarinic acid (Figure 1) [19].…”

Section: Introductionmentioning

confidence: 99%

In Silico Molecular Studies of Antiophidic Properties of the Amazonian Tree Cordia nodosa Lam.

et al. 2019

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We carried out surveys on the use of Cordia nodosa Lam. in the jungles of Bobonaza (Ecuador). We documented this knowledge to prevent its loss under the Framework of the Convention on Biological Diversity and the Nagoya Protocol. We conducted bibliographic research and identified quercetrin as a significant bioactive molecule. We studied its in silico biological activity. The selected methodology was virtual docking experiments with the proteins responsible for the venomous action of snakes. The molecular structures of quercetrin and 21 selected toxins underwent corresponding tests with SwissDock and Chimera software. The results point to support its antiophidic use. They show reasonable geometries and a binding free energy of −7 to −10.03 kcal/mol. The most favorable values were obtained for the venom of the Asian snake Naja atra (5Z2G, −10.03 kcal/mol). Good results were also obtained from the venom of the Latin American Bothrops pirajai (3CYL, −9.71 kcal/mol) and that of Ecuadorian Bothrops asper snakes (5TFV, −9.47 kcal/mol) and Bothrops atrox (5TS5, −9.49 kcal/mol). In the 5Z2G and 5TS5 L-amino acid oxidases, quercetrin binds in a pocket adjacent to the FAD cofactor, while in the myotoxic homologues of PLA2, 3CYL and 5TFV, it joins in the hydrophobic channel formed when oligomerizing, in the first one similar to α-tocopherol. This study presents a case demonstration of the potential of bioinformatic tools in the validation process of ethnobotanical phytopharmaceuticals and how in silico methods are becoming increasingly useful for sustainable drug discovery.

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“…), known as "erva-baleeira" in Brazil, belongs to the family Cordiaceae (GASPARINO;BARROS, 2009) and is largely distributed in Brazil. Several properties of the species, such as anti-inflammatory, antiucer, antiallergic, antitumor, and antioxidant are mainly attributed to the compounds α-humulene and E-caryophyllene, present in its essential oil (FERNANDES et al, 2007;PASSOS et al, 2007;MEDEIROS et al, 2007;ROGÉRIO et al, 2009;OLIVEIRA et al, 2011;MICHIELIN et al, 2011;PARISSOTO et al, 2012;PIMENTEL et al, 2012). Other biological activities, such as antibacterial (MECCIA et al, 2009;MATIAS et al, 2010;PINHO et al, 2012;RODRIGUES et al, 2012) and antifungal activities (SILVA et al, 2012;HOYOS et al, 2012;SILVA et al, 2014) were reported in studies involving the essential oil of V. curassavica.…”

Section: Introductionmentioning

confidence: 99%

Distillation methods affect the chemical composition of Varronia curassavica Jacq. essential oil?

Nizio¹,

Blank²,

Sampaio³

et al. 2018

Biosci. J.

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The objective of this work was to evaluate the chemical composition of essential oil from Varronia curassavica Jacq. obtained by microwave (MI) and hydrodistillation (HD) extraction methods. The MI method tested three powers (500, 600, and 700W), three distillation times (20, 30, and 40 min.), and three water volumes (0, 25, and 50 mL per sample). The HD method tested three distillation times (100, 120, and 140 min.) and three water volumes (1.0, 1.5, and 2.0 L per 3-liter flask). The essential oils were analyzed by GC/MS-FID. The optimal condition for the essential oil extraction by the MI method was 700W for 40 min. (3.28%), regardless of the volume of water. In its turn, the best condition for essential oil extraction by the HD method was 120 min. with 1.0 L of water per flask (3.34%). The most abundant compounds for MI (700 W for 40 min. without water) were shyobunol (26.53%) and bicyclogermacrene (4.96%); and the most abundant compounds for HD (120 min. with 1.0 L of water/flask) were shyobunol (24.00%) and germacrene D-4-ol (10.23%). Methyl farnesoate (2E, 6E) and farnesyl acetate (2Z, 6E) were not detected in the essential oil extracted by HD; however, they were identified by the MI method. By increasing the distillation time and/or volume of water in HD, a reduction was observed for the content of the chemical compounds β-elemene (from 1.23 to 0.97%), Ecaryophyllene (from 5.49 to 4.35%), α-humulene (from 1.80 to 1.43%), alloaromadendrene (from 1.78 to 1.44%), bicyclogermacrene (from 5.63 to 4.55%), and germacrene D-4-ol (from 11.40 to 9.86%). Power, extraction time, and their interactions influenced the content of essential oil obtained by microwave extraction (MI). Within each power, the highest essential oil content was extracted at the longest distillation time (40 min.), except for 600W, where no significant difference was detected between 30 and 40 min. The optimal essential oil contents for both extraction methods were statically similar by the t-test for dependent samples. However, the MI method presents advantages, such as shorter distillation time and less energy and water consumption.

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Cordia verbenacea and secretion of mast cells in different animal species

Cited by 15 publications

References 29 publications

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract

In Silico Molecular Studies of Antiophidic Properties of the Amazonian Tree Cordia nodosa Lam.

Distillation methods affect the chemical composition of Varronia curassavica Jacq. essential oil?

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