Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1

Qing, Rui; Huang, Zezhi; Tang, Yufei; Xiang, Qingke; Yang, Fan

doi:10.1016/j.intimp.2017.03.002

Cited by 18 publications

(10 citation statements)

References 29 publications

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“…Papers selected for analysis were examined for data of effects of cordycepin on cytokines, inflammation or regulation of inflammatory genes in tissue culture. We found 54 papers with data on these subjects [ 28 , 31 , 36 , 43 , 69 , 70 , 71 , 72 , 76 , 78 , 88 , 89 , 94 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 117 , 133 , 270 , 274 , 286 , 326 , 328 , 330 , 332 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 ,…”

Section: Methodsmentioning

confidence: 99%

“…Cordycepin-induced changes in the gene products were noted as increased, unchanged or decreased. We found 38 papers describing such changes [ 28 , 69 , 70 , 71 , 72 , 76 , 88 , 89 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 106 , 108 , 109 , 110 , 112 , 113 , 117 , 270 , 286 , 326 , 330 , 340 , 341 , 342 , 343 , 344 , 345 , 346 , 347 , 348 , 349 ]. In addition, notes were gathered on the effects on the nuclear localisation, level, phosphorylation and DNA binding of NFĸB in the 54 papers found for this subject.…”

Section: Methodsmentioning

confidence: 99%

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A Systematic Review of the Biological Effects of Cordycepin

Radhi

Ashraf²,

Lawrence

et al. 2021

Molecules

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We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion criteria, 791 papers remained. These were read and data on the chosen subjects were extracted. We found 192 papers on the effects of cordycepin on cell survival and proliferation and calculated a median inhibitory concentration (IC50) of 135 µM. Cordycepin consistently repressed cell migration (26 papers) and cellular inflammation (53 papers). Evaluation of 76 papers on signal transduction indicated consistently reduced PI3K/mTOR/AKT and ERK signalling and activation of AMPK. In contrast, the effects of cordycepin on the p38 and Jun kinases were variable, as were the effects on cell cycle arrest (53 papers), suggesting these are cell-specific responses. The examination of 150 animal studies indicated that purified cordycepin has many potential therapeutic effects, including the reduction of tumour growth (37 papers), repression of pain and inflammation (9 papers), protecting brain function (11 papers), improvement of respiratory and cardiac conditions (8 and 19 papers) and amelioration of metabolic disorders (8 papers). Nearly all these data are consistent with cordycepin mediating its therapeutic effects through activating AMPK, inhibiting PI3K/mTOR/AKT and repressing the inflammatory response. We conclude that cordycepin has excellent potential as a lead for drug development, especially for age-related diseases. In addition, we discuss the remaining issues around the mechanism of action, toxicity and biodistribution of cordycepin.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Systematic Review of the Biological Effects of Cordycepin

Radhi

Ashraf²,

Lawrence

et al. 2021

Molecules

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“…13,14 In addition, cordycepin can activate AMPKα and inhibit oxidative stress. [15][16][17] However, no research has been performed to elucidate the effect of cordycepin on cardiac hypertrophy. The purpose of this study was to determine whether cordycepin can attenuate cardiac hypertrophy, induced by 1 μmol/L Ang II in cultured neonatal rat cardiac myocytes in vitro and by pressure overload in mice.…”

Section: Introductionmentioning

confidence: 99%

Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway

Wang

Duan

et al. 2019

J Cellular Molecular Medi

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Increase of myocardial oxidative stress is closely related to the occurrence and development of cardiac hypertrophy. Cordycepin, also known as 3'‐deoxyadenosine, is a natural bioactive substance extracted from Cordyceps militaris (which is widely cultivated for commercial use in functional foods and medicine). Since cordycepin suppresses oxidative stress both in vitro and in vivo, we hypothesized that cordycepin would inhibit cardiac hypertrophy by blocking oxidative stress‐dependent related signalling. In our study, a mouse model of cardiac hypertrophy was induced by aortic banding (AB) surgery. Mice were intraperitoneally injected with cordycepin (20 mg/kg/d) or the same volume of vehicle 3 days after‐surgery for 4 weeks. Our data demonstrated that cordycepin prevented cardiac hypertrophy induced by AB, as assessed by haemodynamic parameters analysis and echocardiographic, histological and molecular analyses. Oxidative stress was estimated by detecting superoxide generation, superoxide dismutase (SOD) activity and malondialdehyde levels, and by detecting the protein levels of gp91 phox and SOD. Mechanistically, we found that cordycepin activated activated protein kinase α (AMPKα) signalling and attenuated oxidative stress both in vivo in cordycepin‐treated mice and in vitro in cordycepin treated cardiomyocytes. Taken together, the results suggest that cordycepin protects against post‐AB cardiac hypertrophy through activation of the AMPKα pathway, which subsequently attenuates oxidative stress.

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“…Cordycepin can decrease the pro‐inflammatory mediators (NO, PGE 2 , TNF‐α, IL‐1β) through modulating the MAPK and NF‐κB signaling pathways in LPS‐mediated RAW264.7 macrophages (Choi et al, 2014). In another study, cordycepin is shown to decrease the production of the inflammatory cytokines, TNF‐α and IL‐6, through the up‐regulation of HO‐1 in LPS‐activated RAW264.7 macrophages (Qing et al, 2017). Additionally, cordycepin reduces the pro‐inflammatory cytokines (IL‐1β, IL‐6, TNF‐α, MCP‐1) and COX‐2 in LPS‐induced RAW264.7 macrophages, by inhibiting the NLRP3 inflammasome and ERK1/2 signaling pathway (J. Yang et al, 2017).…”

Section: Anti‐inflammatory Activitymentioning

confidence: 99%

Anti‐inflammatory effects of cordycepin: A review

Tan

Song

Ren

et al. 2020

Phytotherapy Research

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Cordycepin is the major bioactive component extracted from Cordyceps militaris. In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. This study reviews recent researches on the anti-inflammatory effects and the related activities of cordycepin. The results from our review indicate that cordycepin exerts protective effects against inflammatory injury for many diseases including acute lung injury (ALI), asthma, rheumatoid arthritis, Parkinson's disease (PD), hepatitis, atherosclerosis, and atopic dermatitis. Cordycepin regulates the NF-κB, RIP2/Caspase-1, Akt/GSK-3β/p70S6K, TGF-β/Smads, and Nrf2/HO-1 signaling pathways among others. Several studies focusing on cordycepin derivatives were reviewed and found to down metabolic velocity of cordycepin and increase its bioavailability. Moreover, cordycepin enhanced immunity, inhibited the proliferation of viral RNA, and suppressed cytokine storms, thereby suggesting its potential to treat COVID-19 and other viral infections. From the collected and reviewed information, this article provides the theoretical basis for the clinical applications of cordycepin and discusses the path for future studies focusing on expanding the medicinal use of cordycepin. Taken together, cordycepin and its analogs show great potential as the next new class of anti-inflammatory agents.

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Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1

Cited by 18 publications

References 29 publications

A Systematic Review of the Biological Effects of Cordycepin

A Systematic Review of the Biological Effects of Cordycepin

Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway

Anti‐inflammatory effects of cordycepin: A review

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