Cordyceps More Than Edible Mushroom-A Rich Source of Diverse Bioactive Metabolites with Huge Medicinal Benefits

Elkhateeb, Waill A; GM, Daba

doi:10.37871/jbres1481

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…As the research into Ophiocordyceps has progressed, new products, such as capsules, powder, and solutions, have been introduced in the global market (Zhou et al, 2009 ; Au et al, 2012 ; Hopping et al, 2018 ; Yang et al, 2018 ). Some of the products are Pure Cordyceps TM (Aloha Medicinals Inc.), Jin Shui Bao (Jiangxi Jinshuibao Pharmaceutical Co. Ltd.), Cordyceps capsule (Geneferm Biotechnology Co. Ltd.), and Bailing capsules (Hangzhou East China Pharmaceutical Co., Ltd.; Zhou et al, 2009 ; Elkhateeb and Daba, 2022 ). In India, wild O. sinensis and some mycelial-based products are being used as nutraceuticals and immunity boosters (Sharma, 2004 ; Panda and Swain, 2011 ; Maity, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Systematic analyses with genomic and metabolomic insights reveal a new species, Ophiocordyceps indica sp. nov. from treeline area of Indian Western Himalayan region

et al. 2023

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Ophiocordyceps is a species-rich genus in the order Hypocreales (Sordariomycetes, Ascomycota) depicting a fascinating relationship between microbes and insects. In the present study, a new species, Ophiocordyceps indica sp. nov., is discovered infecting lepidopteran larvae from tree line locations (2,202–2,653 m AMSL) of the Kullu District, Himachal Pradesh, Indian Western Himalayan region, using combinations of morphological and molecular phylogenetic analyses. A phylogeny for Ophiocordyceps based on a combined multigene (nrSSU, nrLSU, tef-1α, and RPB1) dataset is provided, and its taxonomic status within Ophiocordycipitaceae is briefly discussed. Its genome size (~59 Mb) revealed 94% genetic similarity with O. sinensis; however, it differs from other extant Ophiocordyceps species based on morphological characteristics, molecular phylogenetic relationships, and genetic distance. O. indica is identified as the second homothallic species in the family Ophiocordycipitaceae, after O. sinensis. The presence of targeted marker components, viz. nucleosides (2,303.25 μg/g), amino acids (6.15%), mannitol (10.13%), and biological activity data, suggests it to be a new potential source of nutraceutical importance. Data generated around this economically important species will expand our understanding regarding the diversity of Ophiocordyceps-like taxa from new locations, thus providing new research avenues.

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Section: Introductionmentioning

confidence: 99%

Systematic analyses with genomic and metabolomic insights reveal a new species, Ophiocordyceps indica sp. nov. from treeline area of Indian Western Himalayan region

et al. 2023

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“…Cordycepin exhibits various biological activities, including anti-inflammatory, anticancer, antiviral, immunomodulatory, and antioxidant effects [1][2][3]. The medical field has embraced the application of cordyceps to enhance immunity and treat various diseases, including cancer, kidney disease, and diabetes [4]. Moreover, they have found utilization in the beauty industry and as health supplements [5].…”

Section: Introductionmentioning

confidence: 99%

Boosting cordycepin production through plant-based oils for vegetarian consumption

Yuttavanichakul,

Kanthong,

Pungsungvorn

2023

J Appl Res Sci Tech

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Cordyceps fungi, including species such as Cordyceps sinensis and Cordyceps militaris, are known for producing bioactive chemicals, notably cordycepin. Traditional cordyceps cultivation in Thailand relies on silkworm pupae as a substrate in solid-state fermentation, posing challenges in catering to vegetarian consumers. This study aimed to develop a solid-state fermentation process for cordyceps cultivation using vegetable oils, thus modifying the cereals medium and eliminating the need for silkworm pupae while enhancing bioactive chemical production and promoting cordyceps growth. The findings demonstrate that C. militaris can successfully grow and produce adenosine and cordycepin when the culture medium is modified with plant oils. Plant oils, including olive, soybean, peanut, palm, sesame, coconut, and sunflower oil, proved effective for cultivating C. militaris on PDA. Notably, adding a 3% mixture of palm oil in PDA resulted in the most significant promotion of C. militaris mycelium, with a diameter of 5.93 cm. Consequently, the modified cereals medium, incorporating palm oil, was adopted for solid-state fermentation of C. militaris. The results demonstrate that C. militaris can be successfully cultured to produce fruiting bodies comparable and total yields to those obtained using traditional cereals and silkworm pupa medium. Furthermore, there is a notable increase in adenosine and cordycepin production, indicating the potential of this method to enhance C. militaris yield and bioactive chemical output. This research highlights the feasibility of incorporating plant oils as substitutes or additives to silkworm pupae, improving productivity and enabling the production of C. militaris suitable for vegetarian consumption.

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“…Previous reviews of Cordyceps have focused on their nomenclature, structural elucidation, traditional use, and nutraceutical and pharmacological activities [23,34,[46][47][48][49][50][51][52][53][54][55][56]. A bioactive compound (cordycepin) from this fungus has been a compound of choice among researchers, and most neuroprotective studies have been conducted using this compound, while information on other compounds is scarce.…”

Section: Introductionmentioning

confidence: 99%

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

Sharma,

2023

Nutrients

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Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. Cordyceps bioactives (adenosine, N6-(2-hydroxyethyl)-adenosine, ergosta-7, 9 (11), 22-trien-3β-ol, active peptides, and polysaccharides) exert potential antioxidant, anti-inflammatory, and anti-apoptotic activities and display beneficial effects in the management and/or treatment of neurodegenerative disorders in vitro and in vivo. Although a considerable list of compounds is available from Cordyceps, only a few have been evaluated for their neuroprotective potential and still lack information for clinical trials. In this review, the neuroprotective mechanisms and safety profile of Cordyceps extracts/bioactives have been discussed, which might be helpful in the identification of novel potential therapeutic entities in the future.

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Cordyceps More Than Edible Mushroom-A Rich Source of Diverse Bioactive Metabolites with Huge Medicinal Benefits

Cited by 6 publications

References 37 publications

Systematic analyses with genomic and metabolomic insights reveal a new species, Ophiocordyceps indica sp. nov. from treeline area of Indian Western Himalayan region

Systematic analyses with genomic and metabolomic insights reveal a new species, Ophiocordyceps indica sp. nov. from treeline area of Indian Western Himalayan region

Boosting cordycepin production through plant-based oils for vegetarian consumption

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents

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