2016
DOI: 10.1053/j.gastro.2016.03.002
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Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

Abstract: Core fucosylation of the TCR is required for T-cell signaling and production of inflammatory cytokines and induction of colitis in mice. Levels of TCR core fucosylation are increased on T cells from intestinal tissues of patients with IBD; this process might be blocked as a therapeutic strategy.

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Cited by 99 publications
(89 citation statements)
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“…In the cancer microenvironment, blocking core‐fucosylation induces a T cell response. In contrast, in colitis and systemic lupus erythematosus increased core‐fucosylation is accompanied by an increased T cell activation and response . However, in both cases, core‐fucosylation inactivation may be a potential new therapeutic avenue.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In the cancer microenvironment, blocking core‐fucosylation induces a T cell response. In contrast, in colitis and systemic lupus erythematosus increased core‐fucosylation is accompanied by an increased T cell activation and response . However, in both cases, core‐fucosylation inactivation may be a potential new therapeutic avenue.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, a genome wide association study has unraveled FUT8 as a gene of interest in IgG glycosylation, indicating that FUT8 might also have a direct impact on antibody function . T cell abnormalities comprise: failure to transport TCRs to membrane lipid rafts, reduced CD4 + T cell activation, lower production of Th1 and Th2 cytokines with concomitant decrease of the T cell regulatory protein Foxp3 . Thus, FUT8 impairs the communication between B and T cells, being a crucial player across all immune mechanisms both in vitro and in vivo …”
Section: The Immunological Impact Of Glycosylation Defects—an Update mentioning
confidence: 99%
“…This modification, referred to as core-fucosylation, is ubiquitous throughout mammalian tissues and represents an important step in the maturation of complex N-glycans within the Golgi apparatus. Core fucosylation modulates the activity of many cell surface receptors, including: TGFβ1R 1, 2 , EGFR 3 , BCR 4 , TCR 5, 6 , CD14-mediated TLR2/4 signalling 7, 8 , and PD-1 9 . It also modulates the affinity of ligands for their receptors, the most notable example being the role that core fucose plays in decreasing the affinity of immunoglobulin G (IgG) for FcγRIIIa 10, 11 .…”
Section: Introductionmentioning
confidence: 99%
“…Glycosylation modulates protein function, localization, and intermolecular interactions. Therefore, dysregulation of protein glycosylation has been implicated in various diseases such as type 2 diabetes (Ohtsubo et al, 2005), Alzheimer's disease (Kizuka et al, 2015), and IBD (Fu et al, 2011;Fujii et al, 2016;Theodoratou et al, 2014). For instance, levels of core fucosylation in T cells increased in inflamed mucosa in IBD patients.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, levels of core fucosylation in T cells increased in inflamed mucosa in IBD patients. Core fucosylation is catalyzed by α1-6 fucosyltransferase (FUT8), the deficiency of which ameliorates colitis in mice (Fujii et al, 2016). On the other hand, mice lacking intestinal epithelial cell (IEC)intrinsic core 1-derived O-glycans spontaneously develop colitis due to the impairment of the mucus barrier (Fu et al, 2011).…”
Section: Introductionmentioning
confidence: 99%