Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release

Lisuzzo, Lorenzo; Cavallaro, Giuseppe; Parisi, Filippo; Milioto, Stefana; Fakhrullin, Rawil; Lazzara, Giuseppe

doi:10.3390/coatings9020070

Cited by 58 publications

(43 citation statements)

References 59 publications

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“…The diameter shrunk when coated microbeads dried. Similar findings have been reported regarding hydrogel beads [21]. As described in a previous study, the dehydration had a simple power-law time dependence.…”

Section: Characterization Of Coated Microbeads Containing Oleoresinssupporting

confidence: 90%

Design and Development of Oleoresins Rich in Carotenoids Coated Microbeads

et al. 2019

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The aim of this study was to encapsulate the oleoresins rich in carotenoids extracted from sea buckthorn (Hippophae rhamnoides) fruits into a blend of sodium-alginate and κ-carrageenan microbeads (2% w/v) coated by a sodium-alginate (2% w/v) layer prepared using an ionotropic gelation technique with calcium chloride (2% w/v) by dropping method. The fresh obtained coated microbeads had a “fried eggs” like appearance with a size distribution ranging from 4 to 6 mm. The coated microbeads were analyzed for their SEM and fluorescence. The encapsulation efficiency was 92%. Their stability was investigated by evaluation of the physical integrity performance in aqueous media with different pH to mimic the gastrointestinal tract for 24 h at 37 °C under laboratory conditions. The results demonstrated the limitation of the coated microbeads swelling ability under pH 7. The coated microbeads could be a good tool to guarantee oleoresins rich in carotenoids stability and colon delivery. The present study shows an attractive encapsulation system of oleoresins, in order to obtain stable products for further applications.

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Section: Characterization Of Coated Microbeads Containing Oleoresinssupporting

confidence: 90%

Design and Development of Oleoresins Rich in Carotenoids Coated Microbeads

et al. 2019

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“…The drug release percentage scatter diagrams as a function of time and sketch view of the established substrate were shown in Figure 6A-C. The sustained release mechanism of ICA may partly be interpreted by its poor water solubility [42] and the existence of the outside ASP/PLGA coating, which generate a viscous layer that further retarded the drug diffusion to the solvent, similar to a previous report [43]. In the future, drug release amount at more time points, especially for ASP, are needed to be measured to evaluate the kinetic mechanism much accurately.…”

Section: In Vitro Drug Release Profilesupporting

confidence: 83%

Icariin/Aspirin Composite Coating on TiO2 Nanotubes Surface Induce Immunomodulatory Effect of Macrophage and Improve Osteoblast Activity

You

Chen

et al. 2020

Coatings

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Surface coating modification of titanium-based alloys is an efficient way to accelerate early osseointegration in dental implant fields. Icariin (ICA) is a traditional Chinese medicine that has bone activating functions, while aspirin (ASP) is a classical non-steroidal anti-inflammatory drug with good antipyretic and analgesic capabilities. Moreover, poly(lactic–co–glycolic acid) (PLGA) has attracted great attention due to its excellent biocompatibility and biodegradability. We superimposed an ASP/PLGA coating onto ICA loaded TiO2 nanotubes structure so as to establish an icariin/aspirin composite coating on TiO2 nanotubes surface. Scanning electron microscopy, X-ray photoelectron spectroscopy, a contact angle test and a drug release test confirmed the successful preparation of the NT–ICA–ASP/PLGA substrate, with a sustained release pattern of both ICA and ASP. Compared to those cultured on the Ti surface, macrophage cells on the NT-ICA-ASP/PLGA substrate displayed decreased M1 proinflammatory and enhanced M2 proregenerative genes and proteins expression, which implied activated immunomodulatory effect. Moreover, when cultured with conditioned medium from macrophages, osteoblast cells on the NT-ICA-ASP/PLGA substrate revealed improved cell proliferation, adhesion and osteogenic genes and proteins expression, compared with those on the Ti surface. The abovementioned results suggest that the established NT-ICA-ASP/PLGA substrate is a promising candidate for functionalized coating material in Ti implant surface modification.

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“…48,49 Moreover, biohybrid gel beads composed by a chitosan embedded halloysite core in an outer alginate shell were prepared with the aim to enhance the control of the drug delivery. 50 This paper contributes to the design of new smart biohybrid materials that can be used for health applications. Within this, halloysite nanotubes have been employed as both drug molecules nanocontainers and fillers for chitosan biopolymeric matrix.…”

Section: Introductionmentioning

confidence: 99%